Results 41 to 50 of about 47,778 (228)
Poly(ADP-Ribose) polymerase 1 (PARP-1) regulates ribosomal biogenesis in Drosophila nucleoli. [PDF]
PLoS Genetics, 2012 Poly(ADP-ribose) polymerase 1 (PARP1), a nuclear protein, utilizes NAD to synthesize poly(AD-Pribose) (pADPr), resulting in both automodification and the modification of acceptor proteins.
Ernest K Boamah +4 more
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Methylation status of Dnmt1 promoter depends on poly(ADP-ribosy)lation [PDF]
, 2007 Research is focused on CpG islands and on the mechanism that poly(ADP-ribosyl)ation uses to defend the unmethylated state of these important DNA sequences which are located in the promoter regions of the housekeeping genes having a role of transcription ...
Zampieri, Michele
core +1 more source
Noncoding RNAs link PARP1 to heterochromatin [PDF]
Cell Cycle, 2012 Comment on: Guetg C et al. Mol Cell 2012; 45:790-800.
Guetg Claudio, Santoro Raffaella
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PD-L1 Predicts Poor Prognosis in Surgically Resected Limited Stage Small-Cell Lung Cancer
Cancer Management and Research, 2020 Xiao Fu,1,* Zhiyan Liu,2,* Luochengling Xiang,1 Mengjie Liu,1 Xiaoqiang Zheng,1 Jingjing Wang,1 Na Liu,1 Huan Gao,1 Aimin Jiang,1 Yujuan Yang,3 Xuan Liang,1 Zhiping Ruan,1 Tao Tian,1 Yu Yao1 1Department of Medical Oncology, The First Affiliated Hospital ...
Fu X +13 more
doaj
Frontiers in Cell and Developmental Biology, 2021 Myocardial ischemia–reperfusion injury (MIRI), characterized by post-ischemic cardiomyocytes death and reperfusion myocardial damage, is a lethal yet unresolved complication in the treatment of acute myocardial infarction (AMI).
Yifeng Xu +7 more
doaj +1 more source
BMN673 sensitizes rhabdomyosarcoma tumors to irradiation in vivo [PDF]
, 2020 Bone and soft tissue sarcomas are mesenchymal tumors that occur rarely in adults, representing only 1% of total malignancies, but comprise up to 13% of malignant tumors in children.1 Rhabdomyosarcoma, a soft tissue sarcoma that commonly affects children,
Jacob, Connor
core
Poly(ADP-ribose) polymerase-1 and its ambiguous role in cellular life and death
Cell Stress, 2023 The deletion of the gene coding for poly(ADPribose) polymerase-1 (PARP1) or its pharmacological inhibition protects mice against cerebral ischemia and Parkinson’s disease.
Maria Castedo +2 more
doaj +1 more source
Alternative cell death pathways and cell metabolism [PDF]
, 2013 While necroptosis has for long been viewed as an accidental mode of cell death triggered by physical or chemical damage, it has become clear over the last years that necroptosis can also represent a programmed form of cell death in mammalian cells.
Fulda, Simone
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PARP1 Genomics: Chromatin Immunoprecipitation Approach Using Anti-PARP1 Antibody (ChIP and ChIP-seq) [PDF]
, 2011 Poly(ADP-ribose) polymerase1 (PARP1) is a global regulator of different cellular mechanisms, ranging from DNA damage repair to control of gene expression. Since PARP1 protein and pADPr have been shown to persist in chromatin through cell cycle, they may both act as epigenetic markers. However, it is not known how many loci are occupied by PARP1 protein
Niraj, Lodhi, Alexei V, Tulin
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Restoration of Sensitivity in Chemo [PDF]
, 2013 Glioblastoma (GBM) is the most common and aggressive brain tumor in adults. Despite multimodal treatments including surgery, chemotherapy and radiotherapy the prognosis remains poor and relapse occurs regularly.
Boxhammer, Veronika +10 more
core +1 more source