Results 51 to 60 of about 47,778 (228)
Cancer Management and Research, 2020 Mingzhe Zhu,1,* Lei Yang,2,* Xin Wang3 1Department of Obstetrics and Gynecology, Jilin Medical College Affiliated Hospital, Jilin City, Jilin Province 132011, People’s Republic of China; 2Department of Medical Clinic, Yuhuangding Hospital, Yantai ...
Zhu M, Yang L, Wang X
doaj
Genome-wide profiling of PARP1 reveals an interplay with gene regulatory regions and DNA methylation [PDF]
, 2015 Poly (ADP-ribose) polymerase-1 (PARP1) is a nuclear enzyme involved in DNA repair, chromatin remodeling and gene expression. PARP1 interactions with chromatin architectural multi-protein complexes (i.e. nucleosomes) alter chromatin structure resulting in
Al-jumaily, Taha +7 more
core +5 more sources
Radioiodinated PARP1 tracers for glioblastoma imaging [PDF]
EJNMMI Research, 2015 Although the understanding of the genetic and molecular basis of cancer has advanced significantly over the past several decades, imaging and treatment options for glioblastoma patients have been more limited (N Engl J Med 359:492-507, 2008). This is in part due to difficulties in diagnosing this disease early, combined with its diffuse, infiltrative ...
Salinas, Beatriz +7 more
openaire +2 more sources
Cells, 2021 (1) Background: Poly(ADP-ribose) polymerase 1) (PARP1) is a pleiotropic enzyme involved in several cellular processes, e.g., DNA damage repair, regulation of mitosis, and immune response.
Piotr Kupczyk +13 more
doaj +1 more source
Transcriptional Roles of PARP1 in Cancer [PDF]
Molecular Cancer Research, 2014 Abstract Poly (ADP-ribose) polymerase-1 (PARP1) is an abundant, ubiquitously expressed NAD+-dependent nuclear enzyme that has prognostic value for a multitude of human cancers. PARP1 activity serves to poly (ADP-ribose)-ylate the vast majority of known client proteins and affects a number of cellular and biologic outcomes, by mediating ...
Matthew J, Schiewer, Karen E, Knudsen
openaire +2 more sources
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Cells, 2022 RNA polymerase elongation along the gene body is tightly regulated to ensure proper transcription and alternative splicing events. Understanding the mechanism and factors critical in regulating the rate of RNA polymerase II elongation and processivity is
Elena A. Matveeva +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Parp1 deletion rescues cerebellar hypotrophy in xrcc1 mutant zebrafish
Scientific ReportsDefects in DNA single-strand break repair are associated with neurodevelopmental and neurodegenerative disorders. One such disorder is that resulting from mutations in XRCC1, a scaffold protein that plays a central role in DNA single-strand base repair ...
Svetlana A. Semenova +7 more
doaj +1 more source
Cancer Management and Research, 2023 Bustanur Rosidi,1 Diana Priyatno,1 Teguh Pribadi Putra,1 Irawan Yusuf1,2 1Division of Proteomics, Mochtar Riady Institute for Nanotechnology and Medical Science Group, University of Pelita Harapan, Tangerang, Banten, Indonesia; 2Faculty of Medicine ...
Rosidi B, Priyatno D, Putra TP, Yusuf I
doaj