Results 151 to 160 of about 718,683 (284)

Periodontitis and atherosclerotic cardiovascular disease: A critical appraisal

Periodontology 2000, EarlyView., 2023
Abstract In spite of intensive research efforts driving spectacular advances in terms of prevention and treatments, cardiovascular diseases (CVDs) remain a leading health burden, accounting for 32% of all deaths (World Health Organization. “Cardiovascular Diseases (CVDs).” WHO, February 1, 2017, https://www.who.int/news‐room/fact‐sheets/detail ...
Maria Clotilde Carra, Hélène Rangé, Giuseppina Caligiuri, Philippe Bouchard   +3 more
wiley   +1 more source

Physiologically-Based Pharmacokinetic Modeling of the PARP Inhibitor Niraparib. [PDF]

CPT Pharmacometrics Syst Pharmacol
Lewis GJ, Jewell RC, Krishnatry AS, Taskar KS.   +3 more
europepmc   +1 more source

Repurposing antimicrobial agents for neuroprotection: Mechanisms, clinical potential, and challenges

Neuroprotection, EarlyView.
Antimicrobial agents exert neuroprotective effects through modulation of interconnected pathways. Tetracyclines, macrolides, antimalarial agents, sulfones, and antiparasitic agents suppress neuroinflammation, oxidative stress, and apoptosis while preserving mitochondrial function and neurotransmission.
Mohammad Amin Manavi, Mohammadreza Salehi, Razieh Mohammad Jafari, Ramin Goudarzi, Saman Khosravi, Ahmad Reza Dehpour   +5 more
wiley   +1 more source

CDK9 degrader induces BRCAness and sensitizes castration-resistant prostate cancer to PARP inhibitor. [PDF]

Theranostics
Li J, Sun J, Tan W, Li G, Xiao W, Wu J, Yang W, Chen C, Li Y, Liu J, Liu Y, Liu D, Chen XH, Zhu R, Huang R, Yan J.   +15 more
europepmc   +1 more source

Ineffectiveness of immune checkpoint inhibitors in prostate cancer: is it just a question of ‘‐mabs’?

The Journal of Pathology, EarlyView.
Abstract Prostate cancer (PCa) is the second most common type of neoplasm, currently treated with a variety of therapeutic agents. Although advances in treatment over the past decade have improved overall survival, patients with advanced PCa eventually progress from hormone‐sensitive PCa to metastatic castration‐resistant PCa.
Giuseppe Schepisi, Irene Torresan, Emilio Francesco Giunta, Sara Bleve, Nicole Brighi, Elisa Tassinari, Sofia Zanuccoli, Maria Concetta Cursano, Cristian Lolli   +8 more
wiley   +1 more source

First-in-Human Study of the PARP Inhibitor HWH340 in Advanced Solid Tumors with Enrichment for Homologous Recombination Repair Gene Mutations. [PDF]

Drug Des Devel Ther
Zhang J, Wang X, Xu H, Zang A, Zhao J, Chen J, Lei R, Zhang Z, Hao C, Liu Y, Zhou R, He L, Sun T, Ouyang Q, Chen S, Xu J, Zhou W, Shi Y, Tong Z.   +18 more
europepmc   +1 more source

Radiotherapy and Immunotherapy In Hepatocellular Carcinoma: Priming the Tumor Immune Microenvironment From Bench To Bedside

Precision Radiation Oncology, EarlyView.
The dual immunomodulatory network of radiotherapy in hepatocellular carcinoma. Radiotherapy initiates its effects by inducing immunogenic cell death and DNA double‐strand breaks. Immune Activation: Cytosolic DNA from damaged cells activates the cGAS‐STING pathway, triggering IRF3/NF‐κB‐mediated type I interferon production. This enhances dendritic cell
Zhigang Fu, Yang Zhang, Zuomin Wang, Zongjuan Li, Shisuo Du   +4 more
wiley   +1 more source

PARP inhibitor maintenance in first-line ovarian cancer therapy: emerging standards and strategies to overcome resistance. [PDF]

Am J Cancer Res
Chen H.
europepmc   +1 more source

Molecular Basis for Uracil‐DNA‐Glycosylase to Identify DNA Damage in the Nucleosome

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT The DNA base‐excision repair (BER) pathway is initiated by a glycosylase, such as uracil‐DNA‐glycosylase (UDG), which identifies and removes a wrong base incorporated in the DNA sequence. The very early steps in the identification of the DNA damage are crucial to the correct initiation of the repair chain, and become even more complex when ...
Safwen Ghediri, Ralf Blossey, Fabrizio Cleri   +2 more
wiley   +1 more source

Brassinin Inhibits Cell Survival and Autophagy via Modulation of ROS Production and the AMPKα‐beclin1 Signaling Pathway in Gliomas

Phytotherapy Research, EarlyView.
Brassinin, a phytoalexin derived primarily from Chinese cabbage, exhibits potent anticancer activity against glioblastoma (GBM). Mechanistically, brassinin treatment elevates intracellular ROS levels in GBM cells, triggering two parallel outcomes: (i) direct induction of apoptosis, and (ii) suppression of cytoprotective autophagy through downregulation
Sunil Rauniyar, Yuhui Wang, Qiaoshan Zhang, Shicheng Zhang, Jiale Yin, Tong Zhang, Shangfeng Gao, Rutong Yu   +7 more
wiley   +1 more source