Results 181 to 190 of about 77,084 (260)

Correction to 'USP37 counteracts HLTF to protect damaged replication forks and promote survival of BRCA1-deficient cells and PARP inhibitor resistance'. [PDF]

Nucleic Acids Res
europepmc   +1 more source

Randomized phase 2 trial of a PARP inhibitor TSL-1502 in germline BRCA-mutated, HER2-negative locally advanced/metastatic breast cancer. [PDF]

Signal Transduct Target Ther
Lan B, Xu F, Sun T, Qiu F, Wang Y, Wang S, Li W, Zhong Y, Wu X, Ouyang Q, Wang K, Mi X, Liu R, Xu B.   +13 more
europepmc   +1 more source

Combining TAG‐72CAR with anti‐MUC16CAR improves the potency of ovarian cancer treatment

The FEBS Journal, EarlyView.
Tz‐KBBCAR, a combinatorial CAR targeting MUC16 and TAG‐72, enhances the precision of ovarian cancer immunotherapy. By requiring both tumour antigens for full activation, Tz‐KBBCAR was designed to eliminate MUC16+/TAG‐72+ cancer cells, while sparing MUC16+/TAG‐72‐ healthy cells.
Alicia Villatoro, Aurore Dougé, Klara Krpina, Lea‐Marie Schmitz, Christopher Forcados, Fatemeh Kaveh, Andrea Estrella Arias‐Díaz, Pascal Gelebart, Emmet McCormack, Renata Stripecke, Miguel Abal, Ben Davidson, Else Marit Inderberg, Sébastien Wälchli   +13 more
wiley   +1 more source

CRISPR screen identifies autophagy inhibition (GNS561) as a PARP inhibitor (AZD5305) combination strategy in small cell lung cancer. [PDF]

Cancer Metab
Yu T, Barayan R, Song L, Venkatasubramanian V, Tamakuwala J, Nair SN, Philip V, Lok BH.   +7 more
europepmc   +1 more source

A comparative analysis of cell death signalling in RNA and DNA virus infections and potential inhibitory strategies

The FEBS Journal, EarlyView.
RNA and DNA viruses can manipulate host cell death through various mechanisms. RNA viruses (H1N1, SARS‐CoV‐2) induce acute apoptosis, necroptosis, and pyroptosis to promote rapid viral transmission and epithelial barrier damage. In contrast, DNA viruses (HSV‐1, EBV) regulate these mechanisms to sustain a lytic‐latency cycle, evade immune response and ...
Panagiotis Keramidas, Maria Pitou, Amalia Aggeli, Sotiris Varlamis, Theodora Choli‐Papadopoulou   +4 more
wiley   +1 more source

Outcomes of First-Line PARP Inhibitor Therapy in Ovarian Cancer: A Multicenter Retrospective Analysis. [PDF]

J Clin Med
Koksal B, Yildirim HC, Guven DC, Kose F, Koymen G, Ozdemir O, Ozberk U, Algin E, Guliyev M, Demirci NS, Alan O, Baklaci A, Demir B, Topkaya O, Uskent N, Yucel KB, Akdogan O, Koylu B, Selcukbiricik F, Bilgetekin I, Helvaci K, Unal A, Semiz HS, Sakalar T, Sever N, Cicek CM, Dogu GG, Biter S, Bayram E, Yildiz C, Demir H, Bayrakci I, Erdogan B, Kalender ME, Guzel HG, Ozturk B, Karabuga B, Ates O, Cetin EB, Sahbazlar M, Inal A, Sunar V, Basal FB, Asik E, Yildirim A, Oksuz NE, Urun Y, Nayir E, Turker S, On S, Aytac A, Menekse S, Temi YB, Uygun K, Sahin E, Keskinkilic M, Arik Z.   +56 more
europepmc   +1 more source

Molecular Links Between Heat Stress and DNA Damage Response in Plants

Plant, Cell &Environment, EarlyView.
ABSTRACT Climate change poses a major threat to agricultural productivity and, consequently, to global food security. Among the consequences of climate change, heat stress (HS) has emerged as a critical factor limiting crop performance. This has stimulated extensive research over the past decade to elucidate the molecular and physiological mechanisms ...
Adrian Calves‐Ubach, Miriam Szurman‐Zubrzycka   +1 more
wiley   +1 more source

Targeting THOC2-Mediated mRNA Export Induces PARP Inhibitor Vulnerability in DNA Repair-Competent Hepatocellular Carcinoma. [PDF]

Int J Biol Sci
Li X, Yang S, Zhang M, Guo Z, Wang Y, Meng Y, Liu Y, Zhang H, Xu K, Zhang X, Zhai Y, Jin J, He F, Tian C, Sun A.   +14 more
europepmc   +1 more source

The effect of photodynamic therapy in head and neck cancer: A comprehensive review of in vivo models

Photochemistry and Photobiology, EarlyView.
This review evaluates Photodynamic Therapy (PDT) in in vivo head and neck cancer models. PDT effectively generates ROS, reducing tumor growth, cell proliferation and angiogenesis while enhancing survival and immune responses. However, methodological heterogeneity highlights the urgent need for standardized dosimetric protocols to ensure reproducibility
Bibiana Padilha de Menezes da Silva, Rebeca Barros Nascimento, Giovanna Lopes Carvalho, Rebeca Boltes Cecatto, Maria Stella Moreira, Maria Fernanda Setúbal Destro Rodrigues   +5 more
wiley   +1 more source

Efficacy and safety of PARP inhibitor maintenance therapy in elderly ovarian cancer patients: a real-world single-center retrospective cohort study. [PDF]

Front Oncol
Lu J, Song X, Zhang C, Zhu Y, Yang H, Li Y.   +5 more
europepmc   +1 more source