Results 111 to 120 of about 11,256 (207)

A transcriptomic-based model associated with PARP inhibitor sensitivity and immunogenic signatures in ovarian cancer

Discover Oncology
Background Poly (ADP-ribose) polymerase inhibitors (PARPi) have emerged as a major therapeutic advance in ovarian cancer, particularly for patients with BRCA mutations or homologous recombination deficiency (HRD).
Xinxin Sun, Cancan Li, Zhihong Wang, Jie Geng, Wuliang Wang, Kehong Deng, Zhen Xu, Hu Zhao, Dongmei Huang   +8 more
doaj   +1 more source

BRCA1 promoter methylation predicts PARPi response in ovarian cancer: insights from the KOMET study

International audienceObjectives: PARP inhibitors (PARPi) have become the new standard maintenance treatment for patients with advanced homologous recombination deficiency (HRD) ovarian cancer; they are also used upon platinum-sensitive relapse.
de Fraipont, Florence, Hazane-Puch, Florence, Nougarede, Léna, Jacquet, Emmanuelle, Bidart, Marie   +4 more
core   +1 more source

Mechanisms of Synthetic Lethality between loss of POLE3-POLE4 and ATRi/PARPi [PDF]

Efficient and accurate DNA replication by the leading strand polymerase Polis crucial for maintaining genome stability. Despite this, research into the function of the non-catalytic subunits of PolPOLE3 and POLE4, remains limited.
Hill, B
core   +2 more sources

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology
Prostate cancer (PCa) is the second most lethal cancer in men in the US. African American (AA) men have twice the incidence and death rate of European American (EA) men.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
doaj   +1 more source

BRCAness, DNA gaps, and gain and loss of PARP inhibitor–induced synthetic lethality

The Journal of Clinical Investigation
Mutations in the tumor-suppressor genes BRCA1 and BRCA2 resulting in BRCA1/2 deficiency are frequently identified in breast, ovarian, prostate, pancreatic, and other cancers. Poly(ADP-ribose) polymerase (PARP) inhibitors (PARPis) selectively kill BRCA1/2-
Xin Li, Lee Zou
doaj   +1 more source

Beyond Homologous Recombination: Functional Modules of Olaparib Resistance Revealed by CRISPR Screens. [PDF]

Int J Mol Sci
Dildabayeva D, Samarkhanova D, Lezina L.
europepmc   +1 more source

Poly(ADP-Ribose) Polymerase Inhibitors (PARPi) for patients (pts) with locally advanced or metastatic breast cancer (BC): A meta-analysis.

, 2018
Poly(ADP-Ribose) Polymerase Inhibitors (PARPi) for patients (pts) with locally advanced or metastatic breast cancer (BC): A meta ...
Martin Tio (13470733), Sujata Patil (674937), Mark E Robson (13470739), Mustafa Khasraw (13078896), Tiffany A Traina (13470736)   +4 more
core  

Functional biomarkers complementing static BRCA/HRD testing for dynamic PARP inhibitor therapy in ovarian cancer: a narrative review. [PDF]

Front Oncol
Wu T, Zhang P, Xi R, Wang X, Hu L, Shen Y, Tao K, Lu J, Wang G.   +8 more
europepmc   +1 more source

Mitochondrial NADP(H)-dependent de novo dTMP biosynthesis counteracts the cytotoxicity of PARP inhibitors. [PDF]

Proc Natl Acad Sci U S A
Li Q, Shu T, Liu C, Zheng M, Li Y, Zhang L, Fan G, Lu W, Zhang H, Liu P, He X, Zheng H, Liu W, Ye J, Yin Z, Deng X, Zhang C, Huang C, You H.   +18 more
europepmc   +1 more source

Stereotactic radiotherapy for managing ovarian cancer oligoprogression under poly (ADP-ribose) polymerase inhibitors (PARPi)

Objective Poly (ADP-ribose) polymerase inhibitors (PARPi) have become a new standard of care for the maintenance treatment of advanced epithelial ovarian cancer.
Rigo, Michele, Colombo, Nicoletta, Lazzari, Roberta, Mastroleo, Federico, Cattani, Federica, Jereczek-Fossa, Barbara Alicja, Caminiti, Giovanni, Vigorito, Sabrina, Ferrera, Giuseppe, Corrao, Giulia, Chiantera, Vito, Durante, Stefano, Alongi, Filippo, Caruso, Giuseppe, Cuccia, Francesco   +14 more
core   +1 more source