Results 71 to 80 of about 772,908 (331)

Partial Differential Equations [PDF]

, 1988
In this chapter, procedures will be developed for classifying partial differential equations as elliptic, parabolic or hyperbolic. The different types of partial differential equations will be examined from both a mathematical and a physical viewpoint to indicate their key features and the flow categories for which they occur.
openaire   +2 more sources

Lie group classifications and exact solutions for time-fractional Burgers equation

, 2010
Lie group method provides an efficient tool to solve nonlinear partial differential equations. This paper suggests a fractional Lie group method for fractional partial differential equations.
A.B. Malinowska, G. Jmnarie, G.C. Wu, G.C. Wu, G.C. Wu, G.W. Bluman, Guo-Cheng Wu, P.J. Olver, R.K. Gazizov, Z.G. Deng   +9 more
core   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Strong-viscosity Solutions: Semilinear Parabolic PDEs and Path-dependent PDEs

, 2019
The aim of the present work is the introduction of a viscosity type solution, called strong-viscosity solution to distinguish it from the classical one, with the following peculiarities: it is a purely analytic object; it can be easily adapted to more ...
Cosso, Andrea, Russo, Francesco
core  

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

A method for constructing a complete bifurcation picture of a boundary value problem for nonlinear partial differential equations: application of the Kolmogorov-Arnold theorem [PDF]

Известия высших учебных заведений: Прикладная нелинейная динамика
The purpose of this study is to develop a numerical method for bifurcation analysis of nonlinear partial differential equations, based on the reduction of partial differential equations to ordinary ones, using the Kolmogorov-Arnold theorem.
Gromov, Vasily Alexandrovich, Tomashchuk, Korney Kirillovich, Beschastnov, Yury Nikolaevich, Sidorenko, Artem Aleksandrovich, Kakurin, Vasily Vladimirovich   +4 more
doaj   +1 more source

Solution of differential equations by application of transformation groups [PDF]

, 1968
Report applies transformation groups to the solution of systems of ordinary differential equations and partial differential equations. Lies theorem finds an integrating factor for appropriate invariance group or groups can be found and can be extended to
Driskell, C. N., Jr., Gallaher, L. J., Martin, R. H., Jr.   +2 more
core   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source