Results 21 to 30 of about 37,350 (257)

Cyclosporine augments hepatic regenerative response in rats [PDF]

, 1990
A number of mechanisms participate in the hepatic injury that occurs during and following liver transplantation. A normal allograft regenerative response is probably essential for a successful transplant outcome. In this study, the effect of cyclosporine,
Dindzans, V, Eagon, PK, Kahn, D, Lai, H, Makowka, L, Starzl, TE, Van Thiel, DH   +6 more
core   +1 more source

The NADPH oxidase NOX4 regulates redox and metabolic homeostasis preventing HCC progression

Hepatology, EarlyView., 2022
Loss of NOX4 in HCC tumor cells induces metabolic reprogramming in a Nrf2/MYC‐dependent manner to promote HCC progression. Abstract Background and Aims The NADPH oxidase NOX4 plays a tumor‐suppressor function in HCC. Silencing NOX4 confers higher proliferative and migratory capacity to HCC cells and increases their in vivo tumorigenic potential in ...
Irene Peñuelas‐Haro, Rut Espinosa‐Sotelo, Eva Crosas‐Molist, Macarena Herranz‐Itúrbide, Daniel Caballero‐Díaz, Ania Alay, Xavier Solé, Emilio Ramos, Teresa Serrano, María L. Martínez‐Chantar, Ulla G. Knaus, José M. Cuezva, Antonio Zorzano, Esther Bertran, Isabel Fabregat   +14 more
wiley   +1 more source

Laparoscopic Partial Hepatectomy: Animal Experiments [PDF]

Diagnostic and Therapeutic Endoscopy, 1995
As a first step in firmly establishing laparoscopic hepatectomy, we introduce a porcine model of laparoscopic partial hepatectomy. This procedure has been successfully performed under the normal‐pressure or low‐pressure pneumoperitoneum condition supported by the full‐thickness abdominal wall lifting technique.
Inoue, Haruhiro, Goseki, Narihide, Izumi, Yousuke, Takeshita, Kimiya, Nakamura, Hiroshi, Endo, Mitsuo   +5 more
openaire   +2 more sources

c‐Rel–dependent Chk2 signaling regulates the DNA damage response limiting hepatocarcinogenesis

Hepatology, EarlyView., 2022
In response to genotoxic injury, c‐Rel upregulates ATM‐Chk2‐p53 pathway DNA damage proteins to limiting hepatocarcinogenesis. Abstract Background and Aims Hepatocellular carcinoma (HCC) is a leading cause of cancer‐related death. The NF‐κB transcription factor family subunit c‐Rel is typically protumorigenic; however, it has recently been reported as a
Jack Leslie, Jill E. Hunter, Amy Collins, Amelia Rushton, Lauren G. Russell, Erik Ramon‐Gil, Maja Laszczewska, Misti McCain, Marco Y. W. Zaki, Amber Knox, Yixin Seow, Laura Sabater, Daniel Geh, Neil D. Perkins, Helen L. Reeves, Dina Tiniakos, Derek A. Mann, Fiona Oakley   +17 more
wiley   +1 more source

Effect of angiotensin-converting enzyme inhibitor, lisinopril on morphological and biochemical aspects of fibrotic liver regeneration

The Saudi Journal of Gastroenterology, 2016
Background/Aims: Hepatic fibrosis results in defective liver regeneration following partial hepatectomy. Angiotensin converting enzyme (ACE) inhibitors can enhance liver regeneration and are also involved in the reduction of hepatic fibrosis. The present
Aysha Ambreen, Sarwat Jahan, Satwat Malik   +2 more
doaj   +1 more source

The ileum positively regulates hepatic regeneration in rats [PDF]

Acta Cirúrgica Brasileira, 2014
PURPOSE: To test the hypothesis that liver regeneration after partial hepatectomy can be influenced by the ileum.METHODS:Eighteen Wistar rats were distributed into groups of six animals: 1 - ileum resection+ hepatectomy 2/3; 2 - hepatectomy 2/3, and 3 ...
Aldo Cunha Medeiros, Ana Clara Batista Azevedo, Jéssica Mayara de Figueiredo Oséas, Mariana Davim Ferreira Gomes, Fernanda Gurgel de Oliveira, Keyla Borges Ferreira Rocha, Ítalo Medeiros Azevedo, Amália Cínthia Meneses Rêgo, Marília Daniela Ferreira Carvalho   +8 more
doaj   +1 more source

Sex Hormone-Related Functions in Regenerating Male Rat Liver [PDF]

, 1986
Sex hormone receptors were quantitated in normal male rat liver and in regenerating liver at several different times after partial (70%) hepatectomy. Both estrogen and androgen receptor content were altered dramatically by partial hepatectomy.
Aquilino, AM, DiLeo, A, Eagon, PK, Francavilla, A, Ingrosso, M, Panella, C, Polimeno, L, Starzl, TE, Van Thiel, DH   +8 more
core   +1 more source

TP53 R249S mutation in hepatic organoids captures the predisposing cancer risk

Hepatology, EarlyView., 2022
The systematic approach in elucidating the gain‐of‐function (GOF) roles of TP53 mutations in early liver carcinogenesis. Unique downstream targets of TP53 L3 mutations were identified from chormatin immunoprecipitation sequencing in HCC cell lines, followed by a series of validation assays to substantiate the exclusive transcriptional regulations ...
Yin Kau Lam, Jianqing Yu, Hao Huang, Xiaofan Ding, Alissa M. Wong, Howard H. Leung, Anthony W. Chan, Kelvin K. Ng, Mingjing Xu, Xin Wang, Nathalie Wong   +10 more
wiley   +1 more source

Cytochrome P450 enzymes activity in rat liver under conditions of toxic injury and partial hepatectomy [PDF]

The Ukrainian Biochemical Journal
The unique liver ability for reparative regeneration plays a decisive role in restoring its homeostatic potential. However, in certain clinical situations, in particular, due to the damage caused by toxicants of a medicinal origin, the regenerative ...
Н. P. Kopylchuk, I. M. Nykolaichuk, М. S. Ursatyi   +2 more
doaj   +1 more source

Development and validation of a nomogram for survival prediction in hepatocellular carcinoma after partial hepatectomy

BMC Surgery, 2023
Background The prognosis for hepatocellular carcinoma (HCC) is complex due to its high level of heterogeneity, even after radical resection. This study was designed to develop and validate a prognostic nomogram for predicting the postoperative prognosis ...
Yang Lu, Shuang Ren, Jianning Jiang
doaj   +1 more source