Results 51 to 60 of about 32,589 (294)

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Embracing new practices in plant breeding for agroecological transition: A diversity‐driven research agenda

Plants, People, Planet
Societal Impact Statement Plant breeding for agroecological transition (AET) holds the potential to transform agriculture by fostering crop diversification and empowering farmers through collaborative, inter‐ and transdisciplinary research. By adopting a
Myriam Adam, Hélène Fréville, Sophia Alami, Hélène Marrou, David Pot, Sébastien Ricci, Mathieu Thomas, Alexandre Guichardaz, Claire Billot, Nathalie Chantret, Brigitte Gouesnard, Sélim Louafi, Emmanuelle Muller, Joël Romaric Nguepjop, Christophe Pradal, Bénédicte Rhoné, Stéphanie Sidibé‐ Bosc, Muriel Tavaud, Kirsten Vom Brocke, Hélène Joly I   +19 more
doaj   +1 more source

Multi-Parental Advances Generation Inter-Cross Population, to Develop Organic Tomato Genotypes by Participatory Plant Breeding

Agronomy, 2019
A Multi-parent Advanced Generation Intercross (MAGIC) tomato population was developed by crossing eight founder lines chosen to include a wide range of variability. The lines were previously genotyped by a genotyping by sequencing approach.
Gabriele Campanelli, Sara Sestili, Nazzareno Acciarri, Francesco Montemurro, Daniela Palma, Fabrizio Leteo, Massimiliano Beretta   +6 more
doaj   +1 more source

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

Molecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern, Kristian Holm, Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Corinna Bang, Bjørn Naume, Johannes R. Hov, Jon Amund Kyte   +7 more
wiley   +1 more source

PARTAGE DES CONNAISSANCES ENTRE AGRICULTEURS ET CHERCHEURS POUR CREER DES INNOVATIONS VARIETALES. LEÇONS DES PROGRAMMES DE SELECTION PARTICIPATIVE DU SORGHO CONDUITS DANS LA REGION NORD DU NICARAGUA [PDF]

, 2010
N° ISBN - 978-2-7380-1284-5International audienceSharing knowledge between farmers and scientists for creating varietal innovations: lessons from participatory sorghum breeding programs managed in the northern region of Nicaragua.
Aguirre Acuña, Silvio, Castro Briones, Blanca, Guillén, Hugo Francisco, Gómez, Orlando, Hocdé, Henri, Paz, Lino, Trouche, Gilles   +6 more
core   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Utilization of Plant Genetic Resources of Bambara Groundnut Conserved Ex Situ and Genetic Diversification of Its Primary Genepool for Semi-Arid Production

Agriculture, 2022
Bambara groundnut (Vigna subterranea (L.) Verdc) is a nutritious and drought-tolerant crop that is native to Africa. Currently, it possesses a cosmopolitan distribution across the semi-arid agro-ecologies of Africa and its cultivation has extended to ...
Josephine Tafadzwa Pasipanodya, Lydia Ndinelao Horn, Enoch Gbenato Achigan-Dako, Rudo Musango, Julia Sibiya   +4 more
doaj   +1 more source

How can participatory breeding contribute to the maintenance of biodiversity ? Experiences from Rajasthan, Indian [PDF]

, 2001
Participatory plant breeding (PPB) has a considerable potential to maintain local biodiversity. With PPB, breeders and farmers share their knowledge and skills in order to develop varieties or breeding strategies together.
Christinck, Anja, Vom Brocke, Kirsten, Weltzien, Eva   +2 more
core  

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Combining PPB and marker-assisted selection: strategies and experiences with rice [PDF]

, 2016
Participatory plant breeding should not preclude the use of modern biotechnological ...
Prasad, S, Steele, K, Virk, D, Witcombe, J   +3 more
core