Results 51 to 60 of about 1,457 (256)

Improved Tomato Breeding Lines Adapted to Organic Farming Systems Have Enhanced Flavor, Yield, and Disease Resistance

open access: yesHortScience
Most of the tomato (Solanum lycopersicum) varieties currently used in organic farming were bred for conventional farming, often characterized by high-input use.
Ambar Carvallo Lopez   +3 more
doaj   +1 more source

Determining Parental Factors for Clinical Trial Attrition in Pediatric Acute Lymphoblastic Leukemia

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Background/Objectives Despite high enrollment rates on Children's Oncology Group (COG) protocols, attrition after initial consent is challenging, introducing bias and prolonging trial completion. While adult oncology literature has identified predictors of withdrawal, little is known about caregiver decision‐making for child participation in ...
Kimberly L. Stathas   +3 more
wiley   +1 more source

Impact of Japan's 2024 Physician Work‐Style Reform on Pediatric Hematology–Oncology: Educational Implications in a 2‐Year Survey

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Background Japan's 2024 physician work‐style reform introduced legally binding limits on physicians’ working hours, but its impact on education and workforce sustainability in pediatric hematology–oncology (PHO) remains unclear. Procedure We conducted a repeated cross‐sectional study with structured quantitative items and free‐text responses ...
Kiyohiko Kaizu   +7 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Escuela de campo de agricultores para el fitomejoramiento participativo del boniato (Ipomoea batatas (L.) Lam.). Farmer´s Field School for the sweet potato (Ipomoea batatas (L.) Lam.) participatory breeding.

open access: yesAgrisost, 2013
Resumen.Se presenta una Escuela de Campo para capacitar a los agricultores de sub urbanos en el Fitomejoramiento Participativo del boniato. En su concepción se emplearon métodos del nivel teórico (análisis – síntesis, inducción - deducción, histórico y ...
Mario Díaz López
doaj  

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

Bridging genomics and traditional knowledge in sweetpotato: a scientometric pathway for participatory breeding

open access: yesFrontiers in Ecology and Evolution
Sweetpotato (Ipomoea batatas (L.) Lam.) is a globally important root crop cultivated in more than one hundred countries. To map how genetics research has evolved and where actionable gaps remain, we conducted a scientometric analysis of 590 records from ...
Gustavo Reis de Brito   +5 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

open access: yesFEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang   +4 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Participatory plant breeding

open access: yes, 2016
Participatory breeding is a collective mode of genetic improvement of plants which brings together different stakeholders, including researchers, farmers, facilitators, etc. This participatory approach supplements the limits of the delegating mode of plant breeding established post-war in Europe, mode in which research and innovation were delegated by ...
Martineau, Lena   +2 more
openaire   +1 more source

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