Results 61 to 70 of about 32,589 (294)

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

open access: yesMolecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece   +18 more
wiley   +1 more source

From wild to mild and back again: envisioning a new model of crop improvement strategies

open access: yesFrontiers in Horticulture
Climate change creates a leverage point in plant breeding. We must rethink the way we employ plant breeding, utilize genetic diversity, and prioritize edible plant production across the landscape.
Richard C. Pratt   +3 more
doaj   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

open access: yesMolecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck   +12 more
wiley   +1 more source

Improved Tomato Breeding Lines Adapted to Organic Farming Systems Have Enhanced Flavor, Yield, and Disease Resistance

open access: yesHortScience
Most of the tomato (Solanum lycopersicum) varieties currently used in organic farming were bred for conventional farming, often characterized by high-input use.
Ambar Carvallo Lopez   +3 more
doaj   +1 more source

Seeds of resilience: the contribution of commons-based plant breeding and seed production to the social-ecological resilience of the agricultural sector

open access: yesInternational Journal of Agricultural Sustainability, 2022
Building resilience in food systems is a priority to meet societal challenges such as climate change and biodiversity loss. However, there has been little systematic research on the role of seed production in fostering agroecological resilience.
Lea Kliem, Stefanie Sievers-Glotzbach
doaj   +1 more source

Assessing the impact of participatory research in rice breeding on poor rice farming households with emphasis on women farmers: a case study in eastern Uttar Pradesh, India [PDF]

open access: yes, 2016
For the past years since the Consultative Group of International Agricultural Research (CGIAR) Systemwide Initiative on Participatory Research and Gender Analysis (PRGA) was initiated, guides for impact assessment of PRGA have been developed (Lilja and
Atlin, Gary   +4 more
core  

Participatory varietal selection of potato using the mother & baby trial design: A gender-responsive trainer’s guide. [PDF]

open access: yes, 2020
This guide aims to provide step-by-step guidance on facilitating and documenting the PVS dynamics using the MBT design to select, and eventually release, potato varieties preferred by end-users that suit male and female farmers ’different needs, diverse ...
Amaya, N.   +7 more
core   +1 more source

Next‐generation proteomics improves lung cancer risk prediction

open access: yesMolecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj   +4 more
wiley   +1 more source

Participatory plant breeding: a way to arrive at better-adapted onion varieties [PDF]

open access: yes, 2006
The search for varieties that are better adapted to organic farming is a current topic in the organic sector. Breeding programmes specific for organic agriculture should solve this problem.
de Heer, R.   +5 more
core   +2 more sources

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

open access: yesMolecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute   +17 more
wiley   +1 more source

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