Results 71 to 80 of about 196,401 (259)
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Numerical Simulation for Dual Solid Particle Separation Using Fluidized Bed
Engineering ProceedingsParticle separation is a common process in various industries, particularly in mineral processing. Therefore, this research aimed to evaluate the performance of separation method using fluidized bed. The evaluation was performed using silica gel particle
Muhammad Lutfil Amin, Nur Ikhwan
doaj +1 more source
ELECTROFILTER INSTALLATIONS USED FOR THE RETENTION OF AIRPORTED SUBSTANCES [PDF]
Fiabilitate şi Durabilitate, 2021 The burning of fossil fuels for energy purposes causes pollution of all environmental factors. If water and soil pollution is practically as significant both in the process of burning fuels and in the process of extraction and transport, air pollution ...
Florin CIOFU
doaj
Molecular Oncology, EarlyView.Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy +10 more
wiley +1 more source
Experimental Investigation and Numerical Simulation of Aerodynamic Characteristics and Separation Efficiency of an Inertial Particle Separator at Low Altitudes [PDF]
Journal of Applied Fluid MechanicsThe low-altitude airspace plays a vital role in supporting economic development; however, the downwash airflow generated by low-altitude aircraft can entrain ground particles into the engine, posing significant risks to flight safety and operational ...
Z. Zhang, S. Wang, W. Shen, S. Zhang
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
KONA Powder and Particle JournalIn KONA 2022, the fundamentals of two- and multidimensional particle size distributions were introduced. The next question in the field of two- and multidimensional distributions addresses their application to describe a particle process, e.g ...
Edgar Schach +10 more
doaj +1 more source
Molecular Oncology, EarlyView.Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens +6 more
wiley +1 more source
Applied Sciences, 2018 Shear induced diffusion (SID) based flow segregation is a technique that can be used for concentration and fractionation purposes, and it has the potential to become an economical and sustainable alternative for e.g., membrane separation.
Ivon Drijer, Karin Schroën
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Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source