Results 61 to 70 of about 196,401 (259)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Study on Separation Density of Feeding Group Particle in the Gas–Solid Separation Fluidized Bed

Separations
Gas–solid separation fluidized bed is an efficient coal cleaning and separation technology, and this technology has been extensively used in coal separation.
Xuchen Fan, Yuping Fu, Yongliang He, Liying Sun, Yijiang Li   +4 more
doaj   +1 more source

Motion-Blurred Particle Image Restoration for On-Line Wear Monitoring

Sensors, 2015
On-line images of wear debris contain important information for real-time condition monitoring, and a dynamic imaging technique can eliminate particle overlaps commonly found in static images, for instance, acquired using ferrography.
Yeping Peng, Tonghai Wu, Shuo Wang, Ngaiming Kwok, Zhongxiao Peng   +4 more
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Supporting Property Analysis on Oil Film Damper Considering Wedge Clearance

Yuanzineng kexue jishu
Stability analysis is a crucial step in the design process for rotating machinery’s rotordynamics properties, which include static stability and dynamic stability.
JIA Xiangyu1, 2, , WU Tingwei1, 3, BAI Yujie1, 3, ZHANG Kai2, XU Yang2
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Design on Structual Parameter of Oil Film Damper Based on Parameter Fitting

Yuanzineng kexue jishu
Oil film dampers are common supporting components for high-speed rotating machinery, which have the advantages of a simple structure, an easy installation mode, and dependable performance of performing the functions of ensuring rotor system stability and
JIA Xiangyu1, 2, YU Bojun1, 2, WANG Liming1, 2, WU Tingwei1, 2, XU Yang3
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

A Numerical Study on the Effects of Inlet Velocity Variation on Gas-particle Flow in a Cyclone Separator [PDF]

한국정밀공학회지
This study investigated the influence of inlet velocity on the internal flow characteristics and particle separation performance of a cyclone separator.
Geonho Kim, Deokhyeong Kim, Sungbin Lee, Heesung Park   +3 more
doaj   +1 more source