Results 61 to 70 of about 2,357 (169)
Immunohistochemistry protocol for c-FOS and Parvalbumin co-staining of mouse brain tissue slices (30 microns thick).
openaire +1 more source
ABSTRACT Lead is a toxic heavy metal with significant health risks, as maternal lead exposure during pregnancy disrupts fetal neural development through placental transfer, leading to persistent neurological, developmental, and long‐term health consequences in the progeny.
P. Harshitha +3 more
wiley +1 more source
Epilepsy: Epidemiology, Molecular Pathogenesis, and Clinical Management
Epilepsy is a heterogeneous and chronically evolving brain network disorder. This review integrates epidemiological burden, psychiatric comorbidities, and cyclic seizure patterns with multiscale pathogenic mechanisms, including ion‐channel dysfunction, synaptic transmission defects, neuroinflammation, metabolic and mitochondrial dysfunction, and ...
Jian Liu +8 more
wiley +1 more source
Background and Purpose Maternal hypoxia is a recognised risk factor for neurodevelopmental disorders in offspring. Although rodent models of hypoxia have been reported, the detailed pathogenesis of maternal hypoxia‐induced neurodevelopmental disorders remains unclear.
Kentaro Tokudome +6 more
wiley +1 more source
Splice Type‐Specific Effects of Gαo Subunits on Cerebellar Anatomy and Synapse Formation
Heterotrimeric Go alpha subunits are widely expressed in the brain to act as molecular switches. In this study we show that Gαo1 and Gαo2 affect cerebellar morphology and synapse formation in an opposite manner. While knockout of Gαo1 results in cerebellar hypoplasia and reduced synaptic input to Purkinje cells by VGLUT2‐positive brainstem climbing ...
Markus Höltje +2 more
wiley +1 more source
ABSTRACT Hearing impairment is attributed to factors such as age, genetic predisposition, and environmental influences, among which environmental factors are considered modifiable. Among various environmental factors, the role of poor lifestyle habits is particularly critical, yet the specific mechanisms by which they contribute to hearing damage ...
Siyu Qiu +4 more
wiley +1 more source
Unilateral prefrontal TILS reliably increases ipsilateral cytochrome‐c‐oxidase and oxygenated hemoglobin, demonstrating dose‐dependent metabolic efficacy without adverse effects. Contralateral responses are asymmetric: changes emerge later and differ by stimulation side, with stronger right‐hemisphere effects after left‐sided TILS, suggesting ...
Patrick O'Connor +4 more
wiley +1 more source
Parvalbumin interneuron deficits in schizophrenia
Parvalbumin-expressing (PV+) interneurons represent one of the most abundant subclasses of cortical interneurons. Owing to their specific electrophysiological and synaptic properties, PV+ interneurons are essential for gating and pacing the activity of excitatory neurons.
openaire +2 more sources
IgE-Mediated and Non-IgE-Mediated Fish Allergy in Pediatric Age: A Holistic Approach-A Consensus by Diagnostic Commission of the Italian Society of Pediatric Allergy and Immunology. [PDF]
Mastrorilli C +14 more
europepmc +1 more source

