Results 211 to 220 of about 6,824 (230)

RAD51 m6A and PARylation modification orchestrate benzene-induced haematological toxicity

Journal of Hazardous Materials
It is well-established that occupational benzene exposure can cause leukemia. DNA damage repair has great potential in assessing the health risk of benzene, but the role of RAD51, an executor of DNA damage repair, remains unclear in benzene-induced hematotoxicity.
Lin Chen, Fengzhen Cui, Han Li, YuTao Zeng, Zhongming Wu, Weitian Chen, Qiaosheng Wen, Chunnian You, Yunqiang Xu, Lei Sun, Mingwei Sun, Qian Sun, Yuting Chen, Huanwen Tang   +13 more
openaire   +2 more sources

Transcriptional restart: A new role for PARylation in overcoming DNA damage

Cell Chemical Biology
PARP1 detects DNA damage and catalyzes PARylation of proteins to promote DNA damage response. In a study recently published by Nature Chemical Biology, Zhu et al.1 identify a new function for PARP1 in transcriptional restart by PARylation and stabilization of AFF1, which expands PARP1's role to transcriptional recovery.
Jingwei, Liu, Xiaoyu, Song, Liu, Cao
openaire   +2 more sources

The Role of PARylation in Skeletal Muscle During the Development of Cancer Cachexia

2023
Cancer cachexia is a wasting syndrome causing involuntary weight loss and muscle atrophy. PARP1 is a nicotinamide dinucleotide-dependent enzyme that modifies target proteins by PARylation. The reversal process, dePARylation, is mediated by the PARG enzyme.
openaire   +2 more sources

The Role of PARylation in Inflammatory Mediated Subclass of Preeclampsia

Preeclampsia (PE) is a leading cause of maternal and neonatal morbidity and mortality, diagnosed after 20 weeks of gestation. Several subclasses of PE have been identified, each with distinct pathophysiology. Notably, the inflammation-mediated subclass (I-PE) is characterized by a pronounced increase in placental PARylation and a marked depletion of ...
openaire   +1 more source

Stabilization of AFF1 by PARylation ensures transcriptional restart after DNA damage

Nature Chemical Biology
Precise control of transcription is essential for cell survival under stress conditions, including DNA damage. While mechanisms of DNA damage-induced transcriptional silencing are well characterized, how transcription resumes remains less understood. Here we identify a new role for poly(ADP-ribose) polymerase 1 (PARP1) in transcriptional restart during
Feifeng Zhu, Huanyi Fu, Wenxuan Zhu, Chengyu Li, Min Yang, Zeming Feng, Yangqing Shao, Zhuo Li, Yafei Guo, Mengting Huang, Yitong Zhang, Yaohui He, Yi Lu, Zhibing Wu, Qiang Zhou, Huipeng Jiao, Jun Huang, Long Zhang, Yuhua Xue, Huasong Lu   +19 more
openaire   +2 more sources

PARylation at the fork: RSMC bridges replication to sororin-mediated cohesion

Ageing and Cancer Research & Treatment
Sister chromatid cohesion, established during DNA replication, is essential for accurate chromosome segregation. While acetylation of the cohesin subunit SMC3 by ESCO1/2 promotes the recruitment of the cohesin stabilizer Sororin, this pathway is insufficient for full Sororin function. In a recent study, Jiang et al.
Jiacheng Yuan, Qinfu Chen
openaire   +1 more source

Muscle PARP1 inhibition extends lifespan through AMPKα PARylation and activation in Drosophila

Proceedings of the National Academy of Sciences of the United States of America, 2023
Shanshan Guo, Shuang Zhang, Yixiao Zhuang   +2 more
exaly  

PARP-mediated PARylation of MGMT is critical to promote repair of temozolomide-induced O6-methylguanine DNA damage in glioblastoma

Neuro-Oncology, 2021
Shaofang Wu, Xiaolong Li, John F de Groot   +2 more
exaly  

A new underlying mechanism for the neuroprotective effect of bosutinib: Reverting toxicity‐induced PARylation in SIN1‐mediated neurotoxicity

Journal of Biochemical and Molecular Toxicology, 2021
Sinem Yilmaz, Petek Ballar
exaly  

paryll

2009
openaire   +1 more source