Results 201 to 210 of about 6,824 (230)

PARP Inhibitors as Therapeutics: Beyond Modulation of PARylation [PDF]

Cancers, 2020
Poly (ADP-ribose) polymerase (PARP) 1 is an essential molecule in DNA damage response by sensing DNA damage and docking DNA repair proteins on the damaged DNA site through a type of posttranslational modification, poly (ADP-Ribosyl)ation (PARylation). PARP inhibitors, which inhibit PARylation through competitively binding to NAD+ binding site of PARP1 ...
Seock-Ah Im
exaly   +3 more sources

The Enigmatic Function of PARP1: From PARylation Activity to PAR Readers [PDF]

Cells, 2019
Poly(ADP-ribosyl)ation (PARylation) is catalysed by poly(ADP-ribose) polymerases (PARPs, also known as ARTDs) and then rapidly removed by degrading enzymes. Poly(ADP-ribose) (PAR) is produced from PARylation and provides a delicate and spatiotemporal interaction scaffold for numerous target proteins.
Zhao-Qi Wang
exaly   +3 more sources

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Abstract 1360: A PARylation biosensor genetic screen to identify novel PARylation targets

Cancer Research, 2018
Abstract Poly(ADP-ribosylation) (PARylation) is a reversible post-translational protein modification that regulates a number of cellular processes. It is generated by a family of PAR polymerases (PARP), of which PARP1 has recently been exploited as a target in ovarian cancer carrying BRCA1/2 mutations.
Dragomir B. Krastev, Stephen J. Pettitt, James Campbell, Alan Ashworth, Christopher J. Lord   +4 more
openaire   +1 more source

Targeting Ubiquitination with PARylation

Science Signaling, 2012
Poly(ADP-ribosyl)ation may recruit ubiquitin E3 ligases to target proteins.
openaire   +1 more source

PARylation, DNA (De)methylation, and Diabetes

2017
Diabetes and diabetic complications, autoimmunity and inflammatory diseases, have recently become the focus of epigenetic therapy, since with epigenetic drugs it is possible to reverse aberrant gene expression profiles associated with the disease states.
Vidaković, Melita, Tolić, Anja, Grdović, Nevena, Ravichandran, Mirunalini, Jurkowski, Tomasz P.   +4 more
openaire   +3 more sources

Protein PARylation: a novel regulator of fungal virulence

Trends in Microbiology
Protein PARylation is a reversible post-translational modification; however, its role in fungal virulence has remained elusive. Recently, Gao et al. demonstrated that PARylation of two 14-3-3 regulatory proteins by poly(ADP-ribose) polymerase is essential for the virulence of rice blast fungus, highlighting the critical regulatory function of ...
Jiajing Wang, Yuqing Yan, Fengming Song
openaire   +2 more sources

PARG inhibition induces nuclear aggregation of PARylated PARP1

2023
Abstract PARG inhibitors are currently under clinical development for the treatment of DNA repair-deficient cancers, however, their precise mechanism of action is still unclear. Here we report that PARG inhibition causes increased nuclear PARylated PARP1 that limits PARP1 chromatin binding in response to DNA damage. This PARylated PARP1
Sateja Paradkar, Julia Purcell, Annie Cui, Sam Friedman, Ranjini Sundaram, Ryan Jensen, Ranjit Bindra   +6 more
openaire   +1 more source

PARG inhibition induces nuclear aggregation of PARylated PARP1

Structure
Poly (ADP-ribose) glycohydrolase (PARG) inhibitors are currently under clinical development for the treatment of DNA repair-deficient cancers; however, their precise mechanism of action is still unclear. Here, we report that PARG inhibition leads to excessive PARylated poly (ADP-ribose) polymerase 1 (PARP1) reducing the ability of PARP1 to properly ...
Sateja Paradkar, Julia Purcell, Annie Cui, Sam Friedman, Katelyn J. Noronha, Matthew A. Murray, Ranjini K. Sundaram, Ranjit S. Bindra, Ryan B. Jensen   +8 more
openaire   +2 more sources

Genetic Dissection of PARylation in the Filamentous Fungus Neurospora crassa

2011
PARylation is a posttranslational protein modification carried out by PAR polymerases (PARPs). These enzymes function as ADP-ribose transferases that add polymers of ADP-ribose (PAR) to target proteins. PARP proteins have critical functions impacting the aspects of normal human health, such as aging, as well as disease development, particularly cancer.
openaire   +2 more sources

PARylation of HMGA1 desensitizes esophageal squamous cell carcinoma to olaparib

Clinical and Translational Medicine
AbstractAs a chromatin remodelling factor, high mobility group A1 (HMGA1) plays various roles in both physiological and pathological conditions. However, its role in DNA damage response and DNA damage‐based chemotherapy remains largely unexplored. In this study, we report the poly ADP‐ribosylation (PARylation) of HMGA1 during DNA damage, leading to ...
Xin‐Yuan Lei, Kai‐Yue He, Qiu‐Tong Li, Lei Zhang, Dan‐Hui Wu, Jing‐Yu Yang, Jin‐Rong Guo, Meng‐Jie Liu, Zi‐Long Zhao, Jun‐Qi Li, Huai Liu, Yuan Zhao, Yu‐Jia Li, Qian‐Hui Sun, Chen‐Guang Wu, Yun‐Fan Wang, Geng‐Sheng Cao, Gang Wang, Yong‐Ping Jian, Zhi‐Xiang Xu   +19 more
exaly   +4 more sources