Results 51 to 60 of about 4,104 (188)

Bilateral Adrenal Ablation for the Treatment of Ectopic ACTH Syndrome With Severe Hypokalemia: A Case Report and a Literature Review

Clinical Case Reports, Volume 13, Issue 8, August 2025.
ABSTRACT Ectopic ACTH secretion‐related Cushing's syndrome may manifest as a rapid onset of hypercortisolism, elevated urinary free cortisol (UFC) and blood ACTH concentrations, and hypokalemia. However, for patients whose primary lesions are difficult to remove, bilateral adrenalectomy is the recommended treatment method according to guidelines. Here,
Fang Sun, Yuyu Sun, Hongbo He, Zhigang Zhao, Hexuan Zhang, Nan Jiang, Zhiming Zhu   +6 more
wiley   +1 more source

A transplantable phosphorylation probe for direct assessment of G protein-coupled receptor activation. [PDF]

PLoS ONE, 2012
The newly developed multireceptor somatostatin analogs pasireotide (SOM230), octreotide and somatoprim (DG3173) have primarily been characterized according to their binding profiles.
Andrea Kliewer, Anika Mann, Aline Petrich, Florian Pöll, Stefan Schulz   +4 more
doaj   +1 more source

The Effect of 6 Months’ Treatment With Pasireotide LAR on Glucose Metabolism in Patients With Resistant Acromegaly in Real-World Clinical Settings

Frontiers in Endocrinology, 2021
ObjectiveThe aim of the study was to evaluate glucose metabolism, as measured by glycated hemoglobin (HbA1c) levels and the need for antidiabetic medical treatment, in patients with acromegaly resistant to first-generation somatostatin receptors ligands (
Przemysław Witek, Marek Bolanowski, Katarzyna Szamotulska, Agnieszka Wojciechowska-Luźniak, Aleksandra Jawiarczyk-Przybyłowska, Marcin Kałużny   +5 more
doaj   +1 more source

Serial follow-up of presurgical treatment using pasireotide long-acting release with or without octreotide long-acting release for naïve active acromegaly

Journal of the Formosan Medical Association, 2016
The aim of the present study was to evaluate the serial changes of GH and IGF-1 in seven patients with naïve, active acromegaly following presurgical treatment of the somatostatin analog pasireotide long-acting release (LAR) and octreotide LAR.
Jan-Shun Chang, Ham-Min Tseng, Tien-Chun Chang   +2 more
doaj   +1 more source

Somatostatin Receptor Subtype Expression in Patients with Acromegaly and Complicated Clinical Course

Diagnostics, 2021
Somatostatin analogues are considered to be the first line of treatment in acromegaly. Somatostatin analogues of the first generation mainly target the somatostatin receptor (SSTR) subtype 2 and have been proven efficient in the majority of patients with
Robert Pichler, Ognian Kalev, Berndt Tomancok, Michael Sonnberger, Daniela Ehrlich, Marina Hodolic   +5 more
doaj   +1 more source

Successful medical management of a pituitary macroadenoma with features of resistant acromegaly and hyperprolactinemia using pasireotide

Qatar medical journal
Background: The somatostatin analog, pasireotide, is used for the treatment of acromegaly after the failure of surgery and/or first-line medical treatment.
K. Baagar, Amna Sadiq, A. Khan, Z. Dabbous, Zaina Rohani   +4 more
semanticscholar   +1 more source

Complete and sustained remission of hypercortisolism with pasireotide treatment of an adrenocorticotropic hormone (ACTH)-secreting thoracic neuroendocrine tumour: an n-of-1 trial.

Endocrine journal, 2023
N-of-1 trials can serve as useful tools in managing rare disease. We describe a patient presenting with a typical clinical picture of Cushing's Syndrome (CS). Further testing was diagnostic of ectopic Adrenocorticotropic Hormone (ACTH) secretion, but its
Z. Efstathiadou, Efstathios Divaris, A. Michou, G. Kyriakopoulos, M. Kita   +4 more
semanticscholar   +1 more source

Hypersomatotropism and Hypercortisolism Caused by a Plurihormonal Pituitary Adenoma in a Dog

Journal of Veterinary Internal Medicine, Volume 39, Issue 4, July/August 2025.
ABSTRACT A 12‐year‐old, male Labrador Retriever was presented because of polyuria, polydipsia, polyphagia, joint pain, and physical features consistent with acromegaly. Circulating insulin‐like growth factor‐1 (IGF‐1) concentration was increased (> 1000 ng/mL; reference interval [RI], 42–449), suggestive of hypersomatotropism.
Elber A. Soler Arias, Ricardo Rodas Elvir, Adrian F. Daly, Hans S. Kooistra   +3 more
wiley   +1 more source

Pasireotide Versus Octreotide in Preventing Complications After Simultaneous Pancreas-Kidney Transplantation

Transplant International, 2023
In elective pancreatic surgery, somatostatin-analogues pasireotide and octreotide are variably used to reduce postoperative complications, but knowledge on their role in pancreas transplantation is limited.
K. Ahopelto, A. Bonsdorff, Juulia Grasberger, M. Lempinen, A. Nordin, I. Helanterä, V. Sallinen   +6 more
semanticscholar   +1 more source

Evaluation of the Effects of Pasireotide LAR Administration on Lymphocele Prevention after Axillary Node Dissection for Breast Cancer: Results of a Randomized Non-Comparative Phase 2 Study. [PDF]

PLoS ONE, 2016
OBJECTIVE:The aim of this study was to assess the efficacy (response rate centered on 80%) of a somatostatin analog with high affinity for 4 somatostatin receptors in reducing the postoperative incidence of symptomatic lymphocele formation following ...
Elisabeth Chéreau, Catherine Uzan, Emmanuelle Boutmy-Deslandes, Sarah Zohar, Corinne Bézu, Chafika Mazouni, Jean-Rémi Garbay, Emile Daraï, Roman Rouzier   +8 more
doaj   +1 more source