Results 21 to 30 of about 163,378 (254)
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Anuario de Investigaciones, 2011 En este artículo se presentan los vectores principales y los primeros avances del proyecto de investigación 2010-2012: "Transformaciones del concepto de pasaje al acto en el período de la obra de J. Lacan comprendido entre 1963 y 1980.
Pablo D. Muñoz +5 more
doaj
Journal of Family Strengths, 2013 The poor educational outcomes of foster children is recognized as a national problem. The literature is reviewed to define and illustrate the magnitude of the problem. Steps have been taken to improve the problem with passage of the Fostering Connections
Corie G. Hebert
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Anuario de Investigaciones, 2011 En este artículo se presentan los primeros avances del proyecto de investigación UBACyT 2010-2012: "Transformaciones del concepto de pasaje al acto en el período de la obra de J. Lacan comprendido entre 1963 y 1980.
Pablo D. Muñoz
doaj
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
La tragedia del deseo neurótico y las modalidades del acto. Un comentario de Hamlet
Desde el Jardín de Freud, 2009 Resumen Desde la perspectiva ética inaugurada por Lacan, el deseo únicamente puede ser asumido en un acto que pone al sujeto en relación con su causa y lo modifica en lo más íntimo de su estructura.
Megdy David Zawady
doaj +2 more sources
Desde el Jardín de Freud, 2012 Sobrepasar la imagen Se trata de destacar las vías por las cuales el ser humano es susceptible de caer en las redes de la agresividad y los mecanismos a implementar para evitarla.
Luis Izcovich
doaj
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source