Results 41 to 50 of about 1,241,674 (300)

STATE OF PUBLIC BUILDINGS IN GHANA AFTER THE PASSAGE OF THE PERSONS WITH DISABILITY ACT (ACT 715): THE CASE OF TERTIARY INSTITUTIONS

Journal of Construction Project Management and Innovation, 2012
Persons with disability Act (ACT 715) makes it mandatory to put up buildings that are disabled friendly but most designers and contractors in Ghana fail to factor the disabled people in the design and construction of infrastructure.
Samuel K. Ansah, Kwaku Owusu
doaj   +1 more source

Insurance barriers to substance use disorder treatment after passage of mental health and addiction parity laws and the affordable care act: A qualitative analysis

Drug and Alcohol Dependence Reports, 2022
Introduction: : People who use drugs (PWUDs) in the United States historically have had a higher probability of being uninsured. Passage of the Affordable Care Act, the Paul Wellstone and Pete Domenici Health Parity and Addiction Equity was expected to ...
Julia Dickson-Gomez, Margaret Weeks, Danielle Green, Sophie Boutouis, Carol Galletly, Erika Christenson   +5 more
doaj   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Did We Tame the Beast: Views on the US Financial Reform Bill [PDF]

, 2010
Prof. Lawrence Baxter takes a microscope to the ‘Dodd-Frank’ Bill (Dodd-Frank Wall Street Reform and Consumer Protection Act, H.R. 4173) finding a veritable ’Micrographia’ of doubt.
Baxter, Lawrence G.
core   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

La “formación” del analista y sus avatares sintomáticos

Desde el Jardín de Freud, 2009
Resumen La imposibilidad de formalización del acto analítico hace síntoma en las instituciones psicoanalíticas. El final relativo del análisis confronta al sujeto con aquello que podemos caracterizar como lo fundamental de su existencia, como el ...
Francisco Rengifo Lozano
doaj   +2 more sources

Democracy, Race, and Multiculturalism in the Twenty-First Century: Will the Voting Rights Act Ever be Obsolete? [PDF]

, 2006
Part I of this essay begins one hundred years before the passage of the Act, with Reconstruction. I briefly canvas the interracial alliances of the Reconstruction and Redemption periods, underscoring that American democracy has been most responsive to ...
Cashin, Sheryll
core   +2 more sources

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Children and Young People (Scotland) Act : reflections on the passage of the act

Scottish Journal of Residential Child Care, 2014
The Children and Young People (Scotland) Act was passed by the Scottish Parliament on 19th February 2014 and received Royal Assent on March 27th 2014. It has been an interesting journey and not without its challenges. This article provides an overview of the Bill's progress through Parliament, details the Act's provisions, with particular attention ...
openaire   +2 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source