Results 51 to 60 of about 163,378 (254)
Animals, 2019 Gaits are typically classified as walking or running based on kinematics, the shape of the vertical ground reaction force (GRF) curve, and the use of inverted pendulum or spring-mass mechanics during the stance phase.
Hilary M. Clayton, Sarah Jane Hobbs
doaj +1 more source
α‐Synuclein aggregation landscape from phase separation to neurotoxic intermediates
FEBS Letters, EarlyView.Alpha‐synuclein aggregation in Parkinson's disease involves a complex landscape of transient intermediates, including oligomers, fibrils and liquid–liquid phase separation (LLPS). A view is emerging in which LLPS maturation into solid‐like condensates may contribute to the formation of neurotoxic species.
Silvia Arino +2 more
wiley +1 more source
European Journal of Life WritingIn the article, I examine whether an act of coming out as an LGBT+ person can be perceived as the existential equivalent of a religious rite of passage. The paper contains an analysis of fragments of diaries from the collective volume All the Strength I ...
Joanna Anczaruk
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Race equality, human rights and mental health legislation: Recent developments in England and Wales
South African Journal of Psychiatry, 2007 England now has revised mental health legislation following the passage of a mental health Bill through both Houses of Parliament following protracted discussions over seven years.
Lord Patel of Bradford +1 more
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Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
FEBS Letters, EarlyView.Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani +3 more
wiley +1 more source
Responding to LGBT forced migration in East Africa
Forced Migration Review, 2016 Following the passage of Uganda’s Anti-Homosexuality Act in December 2013, hundreds of LGBT individuals fled to Kenya seeking safety. A variety of interventions is needed in both Uganda and Kenya to respond effectively.
Gitta Zomorodi
doaj
A low-water crossing impacts Northern Hog Sucker Hypentelium nigricans movement in an Ozark stream
Journal of Freshwater Ecology, 2020 Streams are complex systems that rely on connectivity to maintain natural ecological function. Low-water crossings are common in small-intermediate sized streams and can restrict longitudinal movement of fishes.
Jeffrey M. Williams +2 more
doaj +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source