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High-Resolution Patch-Clamp Techniques
1985Ion channels are integral membrane proteins that catalyze the diffusion of ions across cell membranes. For example, a single ion channel may pass 20 pA of current, which is equivalent to a flow of ~108 ions/s. Conformational changes in the channel can turn this flow on and off, thereby producing pulses of current.
Anthony Auerbach, Frederick Sachs
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The patch clamp technique: Principles and technical considerations
Journal of Veterinary Cardiology, 2007The development of techniques that allow the high fidelity measurement of small scale ionic currents ushered in a new era of investigation into the role of ion channels in the physiologic and pathophysiologic function of excitable tissue. Based upon the formation of a high resistance (gigaohm) seal with the membrane of the cell being studied, these ...
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What can we learn about cell signalling by combining optical imaging and patch clamp techniques?
Pflügers Archiv, 2002 Optical imaging is a powerful technique with which to investigate the activity, distribution and movement of biomolecules. The increased resolution of images obtained with confocal microscopy now allows us to visualize the signalling events in individual
M. Park, A. Tepikin, O. Petersen
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HTS techniques for patch clamp-based ion channel screening – advances and economy
Expert Opinion on Drug Discovery, 2012Niels Fertig
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The development of high quality seals for silicon patch-clamp chips
Biomaterials, 2010 International audiencePlanar patch-clamp is a two-dimensional variation of traditional patch-clamp. By contrast to classical glass micropipette, the seal quality of silicon patch-clamp chips (i.e. seal resistance and seal success rate) have remained poor
Michel De Waard, Christophe Arnoult
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Neurosurgery, 1995
The introduction of the patch clamp technique less than two decades ago revolutionized the study of cellular physiology by providing a high-resolution method of observing the function of individual ionic channels in a variety of normal and pathological cell types.
L K, Liem +3 more
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The introduction of the patch clamp technique less than two decades ago revolutionized the study of cellular physiology by providing a high-resolution method of observing the function of individual ionic channels in a variety of normal and pathological cell types.
L K, Liem +3 more
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Low-noise patch-clamp techniques.
Methods in enzymology, 1998R A, Levis, J L, Rae
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Advances in the automation of whole-cell patch clamp technology.
Journal of Neuroscience Methods, 2019Electrophysiology is the study of neural activity in the form of local field potentials, current flow through ion channels, calcium spikes, back propagating action potentials and somatic action potentials, all measurable on a millisecond timescale ...
Ho‐Jun Suk +2 more
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