Results 251 to 260 of about 183,075 (317)

Force-Controlled Patch Clamp of Beating Cardiac Cells

open access: yesNano Letters, 2015
From its invention in the 1970s, the patch clamp technique is the gold standard in electrophysiology research and drug screening because it is the only tool enabling accurate investigation of voltage-gated ion channels, which are responsible for action ...
Dario Ossola   +2 more
exaly   +3 more sources

Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches

open access: yesPflugers Archiv European Journal of Physiology, 1981
1. The extracellular patch clamp method, which first allowed the detection of single channel currents in biological membranes, has been further refined to enable higher current resolution, direct membrane patch potential control, and physical isolation ...
O P Hamill, A Marty, Erwin Neher
exaly   +3 more sources

[1] Patch clamp techniques: An overview

open access: yesMethods in Enzymology, 1992
This chapter provides an overview of the patch clamp techniques. The patch clamp technique provides the experimental means for merging the tools of modern molecular and cellular biology with those of electrophysiology.
Michael Cahalan, Erwin Neher
semanticscholar   +3 more sources

Patch Clamp Techniques for Plant Cells

2012
The study of electrophysiological processes at the molecular level, with exquisite sensitivity and full control over the experimental conditions, is possible with the patch clamp technique. A concise overview is given of the different configurations that are used with the technique.
J Theo M Elzenga, Elzenga J Theo M
exaly   +3 more sources

Conventional Micropipette-Based Patch Clamp Techniques

Methods in Molecular Biology, 2013
The patch clamp technique revolutionized the study of ion channels and is considered the gold standard of measuring ion channel activity, from the academic laboratory to industrial-scale drug screening. This technique enables the study of ion channels, from single molecules up to the whole-cell ion channel population, and in their native environment ...
Jonathan D Lippiat
exaly   +3 more sources

Advanced patch-clamp techniques and single-channel analysis

open access: yes, 1999
Much of our knowledge of ion-transport mechanisms in plant cell membranes comes from experiments using voltage-clamp. This technique allows the measurement of ionic currents across the membrane, whilst the voltage is held under experimental control.
P. White   +6 more
semanticscholar   +3 more sources

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