Results 111 to 120 of about 752,311 (360)
Setting up a new gold standard: automated temperature-controlled hERG test on Patchliner®
Frontiers in Pharmacology, 2012 In the present study, the Patchliner® temperature-controlled automated patch clamp system was evaluated for testing actions of drugs on K+ currents through hERG channels expressed in CHO cells at 35-37°C.
Liudmila ePolonchuk
doaj +1 more source
, 2010 The interpretation electrical phenomena in biomembranes is usually based on the assumption that the experimentally found discrete ion conduction events are due to a particular class of proteins called ion channels while the lipid membrane is considered ...
Heimburg, Thomas
core +1 more source
MATLAB-based automated patch-clamp system for awake behaving mice.
Journal of Neurophysiology, 2015 Automation has been an important part of biomedical research for decades, and the use of automated and robotic systems is now standard for such tasks as DNA sequencing, microfluidics, and high-throughput screening. Recently, Kodandaramaiah and colleagues
Niraj S. Desai +4 more
semanticscholar +1 more source
Transducer Materials Mediated Deep Brain Stimulation in Neurological Disorders
Advanced Functional Materials, EarlyView.This review discusses advanced transducer materials for improving deep brain stimulation (DBS) in neurological disorders. These materials respond to light, ultrasound, or magnetic fields, enabling precise, less invasive neuromodulation. Their stimulus‐responsive properties enhance neural control and adaptive therapy, paving the way for next‐generation ...
Di Zhao +5 more
wiley +1 more source
Protocol for pressure-clamped patch-clamp recording at the node of Ranvier of rat myelinated nerves
STAR Protocols, 2021 Summary: The patch-clamp recording technique is indispensable for studying ion channel functions of cells but is challenging to apply to the node of Ranvier, a key site where action potentials are conducted along myelinated nerves.
Hirosato Kanda +3 more
doaj
Frontiers in Pharmacology, 2011 All excitable cell functions rely upon ion channels that are embedded in their plasma membrane. Perturbations of ion channel structure or function result in pathologies ranging from cardiac dysfunction to neurodegenerative disorders.
Christophe ePy +11 more
doaj +1 more source
A Human-Derived Monoclonal Antibody Targeting Extracellular Connexin Domain Selectively Modulates Hemichannel Function [PDF]
, 2019 Connexin hemichannels, which are plasma membrane hexameric channels (connexons) composed of connexin protein protomers, have been implicated in a host of physiological processes and pathological conditions. A number of single point pathological mutations
Buratto, Damiano +12 more
core +1 more source
Microchip amplifier for in vitro, in vivo, and automated whole cell patch-clamp recording.
Journal of Neurophysiology, 2015 Patch clamping is a gold-standard electrophysiology technique that has the temporal resolution and signal-to-noise ratio capable of reporting single ion channel currents, as well as electrical activity of excitable single cells.
R. Harrison +7 more
semanticscholar +1 more source
Advanced Functional Materials, EarlyView.Wood‐based broadband blackbody is achieved by reconfiguration of wood with lignin nanoparticles prior carbonization. Neglectable reflectivity from the visible to infrared wavelengths is obtained by combining thin nanostructures originated from the wood cell walls with long‐range microcavities in the wood lumina.
Bin Zhao +7 more
wiley +1 more source
Reducing agents facilitate membrane patch seal integrity and longevity
ChannelsThe patch clamp method is a widely applied electrophysiological technique used to understand ion channel activity and cellular excitation. The formation of a high resistance giga-ohm seal is required to obtain high-quality recordings but can be ...
Damayantee Das +5 more
doaj +1 more source