Patch-Clamp- and <sup>15</sup>N Isotope Tracer-Based Techniques Reveal the Transport Characteristics of SlGAT1 and the Metabolic Flow of Exogenous GABA Under Salt Stress. [PDF]
Plant Cell EnvironYuan D +6 more
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Haloperidol, a typical antipsychotic, inhibits 5-HT<sub>3</sub> receptor-mediated currents in NCB-20 cells: a whole-cell patch-clamp study [PDF]
Korean J Physiol PharmacolPark YS +4 more
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Clinical interpretation of KCNH2 variants using a robust PS3/BS3 functional patch-clamp assay. [PDF]
HGG AdvThomson KL +12 more
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Genetically engineered human embryonic kidney cells as a novel vehicle for dual patch clamp study of human gap junction channels. [PDF]
Biochem JChen H +4 more
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Correction to: Heterozygous KCNH2 variant phenotyping using Flp-In HEK293 and high-throughput automated patch clamp electrophysiology. [PDF]
Biol Methods Protoceuropepmc +1 more source
Force-Controlled Patch Clamp of Beating Cardiac Cells [PDF]
Nano Letters, 2015 From its invention in the 1970s, the patch clamp technique is the gold standard in electrophysiology research and drug screening because it is the only tool enabling accurate investigation of voltage-gated ion channels, which are responsible for action ...
János Voros +2 more
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The introduction of the patch clamp technique less than two decades ago revolutionized the study of cellular physiology by providing a high-resolution method of observing the function of individual ionic channels in a variety of normal and pathological cell types.
L K, Liem +3 more
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Abstract Many ion channels are recognized as amenable targets for a range of disease states and conditions. However, the process of discovering drugs is highly influenced by the chemical doability, the biological confidence in rationale of the approach and the ‘screenability’.
Claire, Wood +2 more
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