Results 141 to 150 of about 326,151 (193)
Some of the next articles are maybe not open access.
Computer-assisted patch clamping
2010 IEEE International Conference on Robotics and Automation, 2010Patch clamping is an electrophysiological technique that permits the measurement of ion channel activity in many different kinds of cells. Placement of the patch clamp electrodes using micromanipulators is a time consuming and complicated task due to the lack of depth perception of microscope optics and the constrained physical environment. In order to
Mahdi Azizian +3 more
openaire +2 more sources
An Introduction to Patch Clamp Recording
2020Electrophysiology is an essential tool aiding the study of the functions and dysfunctions of electrically excitable cells and their networks. The patch clamp method is a refined electrophysiological technique that can directly measure the membrane potential and/or the amount of current passing across the cell membrane. The patch clamp technique is also
Charlotte L, Hill, Gary J, Stephens
openaire +2 more sources
2020
Intact and functioning brain enables quantification of neural activities directly associated with real world such as visual and auditory information. In vivo patch clamp can record different types of neuronal activity, such as spiking responses, membrane potential dynamics, and synaptic currents (e.g., EPSC, IPSC) in either anesthetized or awake or ...
Yi, Zhou, He, Li, Zhongju, Xiao
openaire +2 more sources
Intact and functioning brain enables quantification of neural activities directly associated with real world such as visual and auditory information. In vivo patch clamp can record different types of neuronal activity, such as spiking responses, membrane potential dynamics, and synaptic currents (e.g., EPSC, IPSC) in either anesthetized or awake or ...
Yi, Zhou, He, Li, Zhongju, Xiao
openaire +2 more sources
1995
In this chapter, I shall explain how to set-up a patch-clamp technique. The aim is to guide researchers in their initial steps in the field of electrophysiology, describing the instrumentation needed, as well as the technique itself. This chapter has been written assuming that the reader has a basic knowledge of electrophysiology.
openaire +2 more sources
In this chapter, I shall explain how to set-up a patch-clamp technique. The aim is to guide researchers in their initial steps in the field of electrophysiology, describing the instrumentation needed, as well as the technique itself. This chapter has been written assuming that the reader has a basic knowledge of electrophysiology.
openaire +2 more sources
2013
Ion channels are integral membrane proteins that regulate the flow of ions across the plasma membrane and the membranes of intracellular organelles of both excitable and non-excitable cells. Ion channels are vital to a wide variety of biological processes and are prominent components of the nervous system and cardiovascular system, as well as ...
Carol J, Milligan, Clemens, Möller
openaire +2 more sources
Ion channels are integral membrane proteins that regulate the flow of ions across the plasma membrane and the membranes of intracellular organelles of both excitable and non-excitable cells. Ion channels are vital to a wide variety of biological processes and are prominent components of the nervous system and cardiovascular system, as well as ...
Carol J, Milligan, Clemens, Möller
openaire +2 more sources
An integrated patch-clamp amplifier for high-throughput planar patch-clamp systems
2008 IEEE International Symposium on Circuits and Systems (ISCAS), 2008We present a fully-integrated implementation of a patch-clamp measurement system. The system was implemented in a 0.5mum silicon-on-sapphire process and is capable of recording cell membrane currents up to plusmn20nA, with a rms noise of 5pA at 10kHz bandwidth.
Pujitha Weerakoon +3 more
openaire +1 more source
A patch-clamp study of Bacillus subtilis
Biochimica et Biophysica Acta (BBA) - Biomembranes, 1992In patch-clamp experiments on giant protoplasts of the Gram-positive bacterium Bacillus subtilis, membrane stretch resulted in an initial transient collapse of the membrane resistance, after which stretch-activated, voltage modulated, high-conductance channels could be observed.
SZABO', ILDIKO' +2 more
openaire +3 more sources
The patch-clamp technique is one of the most useful tools to analyze the function of electrically active cells such as neurons. This technique allows for the analysis of proteins (ion channels and receptors), cells (neurons), and synapses that are the building blocks of neuronal networks.
openaire +2 more sources
openaire +2 more sources
A hybrid patch clamp amplifier
Journal of Neuroscience Methods, 1989The current-to-voltage convertor used in patch clamping is analyzed for noise generation and the major noise sources determined. A hybrid patch clamp amplifier design is theoretically analyzed. Here it is shown that by differentiation and recombining of signals the original input signal can be reconstructed.
openaire +2 more sources
Nihon rinsho. Japanese journal of clinical medicine, 1997
Patch clamp technique was applied to variety of cells for variety of purposes. There are several modifications made for the technique and we can now record not only from the single channel but also from the whole cell membrane. The application of the patch recording technique was expanded and recordings were made recently from brain slice preparations.
T, Hashimoto +4 more
openaire +1 more source
Patch clamp technique was applied to variety of cells for variety of purposes. There are several modifications made for the technique and we can now record not only from the single channel but also from the whole cell membrane. The application of the patch recording technique was expanded and recordings were made recently from brain slice preparations.
T, Hashimoto +4 more
openaire +1 more source