FEBS Letters, EarlyView.Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley +1 more source
To Be Financed or Not... - The Role of Patents for Venture Capital Financing [PDF]
This paper investigates how patent applications and grants held by new ventures improve their ability to attract venture capital (VC) financing. We argue that investors are faced with considerable uncertainty and therefore rely on patents as signals when
Haeussler, Caroline +2 more
core +3 more sources
Biorefinery and sustainability for the production of biofuels and value-added products: A trends analysis based on network and patent analysis. [PDF]
PLoS One, 2023 Barragán-Ocaña A +4 more
europepmc +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
The state of the art and future trends of root canal files from the perspective of patent analysis: a study design. [PDF]
Biomed Eng Online, 2022 Jiang J +6 more
europepmc +1 more source
A Changing Climate: Statistical Evidence of the Intellectual Property Landscape of Clean Energy Technologies [PDF]
The intellectual property (IP) system plays an important role in the development and diffusion of technologies by determining the institutional context in which transactions occur.
Ghafele, Roya, Gibert, Benjamin
core +1 more source
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
A Comprehensive Review of Patented Technologies to Fabricate Orodispersible Films: Proof of Patent Analysis (2000-2020). [PDF]
Pharmaceutics, 2022 Gupta MS +3 more
europepmc +1 more source
Research, patent analysis and prospects of application of in-line separator technology [PDF]
, 2023 Lenskih Alexander Viktorovich
openalex +1 more source
Molecular Oncology, EarlyView.AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou +5 more
wiley +1 more source