Results 81 to 90 of about 6,734 (227)

Antibiotic-Induced Pathobiont Dissemination Accelerates Mortality in Severe Experimental Pancreatitis [PDF]

Frontiers in Immunology, 2017
Although antibiotic-induced dysbiosis has been demonstrated to exacerbate intestinal inflammation, it has been suggested that antibiotic prophylaxis may be beneficial in certain clinical conditions such as acute pancreatitis (AP). However, whether broad-spectrum antibiotics, such as meropenem, influence the dissemination of multidrug-resistant (MDR ...
Fernanda S. Soares, Flávia C. Amaral, Natália L. C. Silva, Matheus R. Valente, Lorena K. R. Santos, Lívia H. Yamashiro, Mara C. Scheffer, Fernanda V. E. S. Castanheira, Raphael G. Ferreira, Laura Gehrke, José C. Alves-Filho, Luciano P. Silva, Luciano P. Silva, André Báfica, André Báfica, Fernando Spiller, Fernando Spiller   +16 more
openaire   +3 more sources

The ageing holobiont: crosstalk between telomere dynamics, oxidative stress and the gut microbiome

Biological Reviews, EarlyView.
ABSTRACT The gut tissue is at the frontline of early onset of ageing. It exhibits high cell turnover rates and rapid telomere shortening, which can have systemic effects on the developing or senescing organism. We conducted a literature review of studies on the crosstalk between telomere length dynamics, telomerase activity, oxidative stress, and gut ...
Michael L. Pepke, Søren B. Hansen, Morten T. Limborg   +2 more
wiley   +1 more source

Construction of Chronic Kidney Disease Mouse Model Induced by Diets With Different Adenine Content

Food Safety and Health, EarlyView.
By administering a 4 weeks adenine diet to C57BL/6J mice, we identified 0.2% adenine in purified feed as the optimal chronic kidney disease model. This model induces severe renal damage, gut dysbiosis, uremic toxin accumulation, and CKD mineral bone disorder, providing a clinically relevant platform for mechanistic and therapeutic studies.
Wanjun Liao, Jiayao Wang, Yilian Huang, Na Zhang, Xiaodan Shi, Zongcai Tu, Zuohua Xie, Tao Yuan, Hongmei Yin   +8 more
wiley   +1 more source

Host gene–microbiome interactions: molecular mechanisms in inflammatory bowel disease [PDF]

, 2017
Recent studies have identified links between host genetic variants and microbial recognition of the microbiome. Defects in host–microbiome interactions in individuals harboring inflammatory bowel disease risk alleles may result in imbalances of the ...
Chu, Hiutung
core   +2 more sources

Microbial differences between dental plaque and historic dental calculus are related to oral biofilm maturation stage [PDF]

, 2019
Dental calculus, calcified oral plaque biofilm, contains microbial and host biomolecules that can be used to study historic microbiome communities and host responses.
CJ Adler, C Warinner, C Warinner, S Buckley, IM Velsko, J Hendy, ID Mandel, C Warinner, C Walker, V Zijnge, P Ramberg, D Belstrøm, PE Kolenbrander, WG Wade, SS Socransky, IM Velsko, SC Holt, M Umeda, BH Mullally, JW Lee, IM Velsko, LM Shaddox, AW Aruni, KL Cross, L Albayrak, S Yost, VM Barnes, JL Ebersole, S Yost, P Jorth, A Basic, RR Jersie-Christensen, T Imamura, LS Weyrich, AA Ribeiro, EL Gross, A Simón-Soro, Zachary D. Moye, O Manor, SM Dabdoub, D Belstrøm, RC Page, S Hillson, A Ogden, S Brooks, JL Buckberry, D Ferembach, CO Lovejoy, TW Phenice, LAF Frantz, P Skoglund, P Skoglund, M. Meyer, A Ginolhac, H Jónsson, A Peltzer, M Schubert, H Li, H Li, M Meyer, D Knights, N Segata, DT Truong, DH Parks, DH Parks, M Bastian, R Overbeek, DH Huson, MC Chambers, FE Dewhirst   +69 more
core   +4 more sources

Inadequate Zinc Intake in Adolescents Aggravates Inflammatory Bowel Disease by Inhibiting Antibody Class Switch Recombination in Mucosal B Cells Through Intestinal Microbial‐Derived KMV

iMetaMed, EarlyView.
The study reveals that inadequate zinc intake disrupts gut microbiota's ability to degrade isoleucine, leading to the accumulation of metabolite KMV. KMV inhibits antibody class‐switching in mucosal B cells by suppressing the p‐ATM‐CTIP‐Hmces pathway, impairing IgA/IgG production.
Wenbo Jiang, Yiding Geng, Bai Li, Conghui Qiao, Zijie Liu, Xinyu Shan, Xinyang Wang, Wei Wei, Tianshu Han   +8 more
wiley   +1 more source

A longitudinal analysis of the vaginal microbiota and vaginal immune mediators in women from sub-Saharan Africa [PDF]

, 2017
In cross-sectional studies increased vaginal bacterial diversity has been associated with vaginal inflammation which can be detrimental for health. We describe longitudinal changes at 5 visits over 8 weeks in vaginal microbiota and immune mediators in ...
Buyze, J, Cools, P, Crucitti, T, Delany-Moretlwe, S, Hardy, L, Jespers, V, Joseph, S, Kyongo, J, Mwaura, M, Ndayisaba, G, van de Wijgert, JHHM, Vanham, G   +11 more
core   +3 more sources

In-vitro susceptibility of gut pathobiont associated with microbial translocation to cotrimoxazole and antiretroviral

Scientific African, 2019
The human gut microbiota consortium consists of microorganisms that are sensitive to some antimicrobial agents. These gut microbiota are essential in upholding a healthy gut environment. A few of the gut microbiota has been described as pathobiont, which
Simon Eyongabane AKO, Eric Achidi AKUM, Céline Nguefeu NKENFOU, Jules Clement N. ASSOB, Thumamo Benjamin POKAM   +4 more
doaj   +1 more source

Salivary microbiota and clinical periodontal measures predicting cardiometabolic disease mortality: A nationwide survey

Journal of Periodontology, EarlyView.
Abstract Background Although periodontitis and oral microbiota are linked to cardiometabolic diseases (CMD), it is unclear if they similarly predict CMD mortality. We compared the predictive ability of salivary microbiota and periodontal disease measures for CMD mortality in the National Health and Nutrition Examination Survey (NHANES).
Hamdi S. Adam, Weihua Guan, Abigail J. Johnson, Sanaz Sedaghat, Charlene Goh, James S. Pankow, Ryan T. Demmer   +6 more
wiley   +1 more source

CVID enteropathy is characterized by exceeding low mucosal IgA levels and interferon-driven inflammation possibly related to the presence of a pathobiont. [PDF]

, 2018
Common variable immunodeficiency (CVID), the most common symptomatic primary antibody deficiency, is accompanied in some patients by a duodenal inflammation and malabsorption syndrome known as CVID enteropathy (E-CVID).The goal of this study was to ...
Dong, Xiaoxi, Fuss, Ivan J, Greer, Renee L, Gurung, Manoj, Montgomery-Recht, Kim, Morgun, Andrey, Peremyslova, Ekaterina, Quezado, Martha, Shulzhenko, Natalia, Sosnovtsev, Stanislav, Strober, Warren, Vasquez-Perez, Stephany, Vyshenska, Dariia, Yao, Michael   +13 more
core