Results 81 to 90 of about 119,423 (270)

Pathogen recognition by the long pentraxin PTX3 [PDF]

, 2011
Innate immunity represents the first line of defence against pathogens and plays key roles in activation and orientation of the adaptive immune response. The innate immune system comprises both a cellular and a humoral arm.
F. Moalli, C. Garlanda, Marina Sironi, Jaillon, Sebastien, S. Jaillon, Antonio Inforzato, Moalli, Federica, Barbara Bottazzi, Bottazzi, Barbara, Mantovani, Alberto, Alberto Mantovani, Inforzato, Antonio, Federica Moalli, B. Bottazzi, A. Mantovani, Sebastien Jaillon, Sironi, Marina, A. Inforzato, Cecilia Garlanda, Garlanda, Cecilia, M. Sironi   +20 more
core   +1 more source

Recognition of Elicitors in Grapevine: From MAMP and DAMP Perception to Induced Resistance

Frontiers in Plant Science, 2019
In a context of a sustainable viticulture, the implementation of innovative eco-friendly strategies, such as elicitor-triggered immunity, requires a deep knowledge of the molecular mechanisms underlying grapevine defense activation, from pathogen ...
Marie-Claire Héloir, Marielle Adrian, Daphnée Brulé, Justine Claverie, Sylvain Cordelier, Xavier Daire, Stéphan Dorey, Adrien Gauthier, Adrien Gauthier, Christelle Lemaître-Guillier, Jonathan Negrel, Lucie Trdá, Lucie Trdá, Sophie Trouvelot, Elodie Vandelle, Elodie Vandelle, Benoit Poinssot   +16 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Engineering plant resistance by constructing chimeric receptors that recognize damage-associated molecular patterns (DAMPs) [PDF]

, 2011
An efficient sensing of danger and a rapid activation of the immune system are crucial for the survival of plants. Conserved pathogen/microbe-associated molecular patterns (PAMPs/MAMPs) and endogenous molecular patterns, which are present only when the ...
DE LORENZO, Giulia, Giulia De Lorenzo, SICILIA, Francesca, Daniel Valentin Savatin, Felice Cervone, SAVATIN, DANIEL VALENTIN, Francesca Sicilia, Brutus, Alexandre, CERVONE, Felice, Alexandre Brutus   +9 more
core   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

The Cladosporium fulvum Avr2 protein behaves both as a virulence and an avirulence factor [PDF]

, 2010
Plants are not able to move or escape and have to confront environmental challenges like nutrient and water deprivation, low and high temperatures, and biotic stress imposed by pathogens like viruses, bacteria, fungi, nematodes and insects that all ...
van t Klooster, J.W., Klooster, J.W., van t   +1 more
core  

The Third Dimension of Reading the Sugar Code by Lectins [PDF]

, 2013
Coding of biological information is not confined to nucleic acids and proteins. Endowed with the highest level of structural versatility among biomolecules, the glycan chains of cellular glycoconjugates are well-suited to generate molecular messages ...
Murphy, Paul, André, Sabine, Sabine André, Paul V. Murphy, Murphy, Paul V., Gabius, Hans-Joachim, Hans-Joachim Gabius, Paul Murphy   +7 more
core   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Bioinformatic and functional characterisation of Globodera pallida effector genes [PDF]

, 2012
Pathogens secrete molecules, termed effectors, to manipulate their host to the benefit of the pathogen. Effectors of plant parasitic nematodes are predicted to have a range of functions such as facilitating invasion, initiation and maintenance of the ...
Thorpe, Peter
core  

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source