Results 71 to 80 of about 118,779 (271)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Functional Characterization of the Small Heat Shock Protein Hsp12p from Candida albicans [PDF]

, 2012
Hsp12p is considered to be a small heat shock protein and conserved among fungal species. To investigate the expression of this heat shock protein in the fungal pathogen Candida albicans we developed an anti-CaHsp12p antibody.
Mühlschlegel, Fritz A., Fritz A. Mühlschlegel, De Sordi Luisa, Luisa De Sordi (146209), Fritz A. Mühlschlegel (146212), Fu Man-Shun, De Sordi, L, Fu, Man Shun, Fu, MS, Fritz A Mühlschlegel, Man-Shun Fu, Luisa De Sordi, Mühlschlegel Fritz A., De Sordi, Luisa, Mühlschlegel, FA, Luisa De Sordi¤b, Man-Shun Fu (146203)   +16 more
core   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Recent advances in plant immunity: recognition, signaling, response, and evolution

Biologia Plantarum, 2013
Innate immune system is employed by plants to defend against phytopathogenic microbes through specific perception of non-self molecules and subsequent initiation of resistance responses.
S. Hou, C. Zhang, Y. Yang, D. Wu
doaj   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Pathogen recognition by the long pentraxin PTX3 [PDF]

, 2011
Innate immunity represents the first line of defence against pathogens and plays key roles in activation and orientation of the adaptive immune response. The innate immune system comprises both a cellular and a humoral arm.
F. Moalli, C. Garlanda, Marina Sironi, Jaillon, Sebastien, S. Jaillon, Antonio Inforzato, Moalli, Federica, Barbara Bottazzi, Bottazzi, Barbara, Mantovani, Alberto, Alberto Mantovani, Inforzato, Antonio, Federica Moalli, B. Bottazzi, A. Mantovani, Sebastien Jaillon, Sironi, Marina, A. Inforzato, Cecilia Garlanda, Garlanda, Cecilia, M. Sironi   +20 more
core   +1 more source

Determination of the Impact of High-Intensity Pulsed Electromagnetic Fields on the Release of Damage-Associated Molecular Pattern Molecules

, 2023
High-Intensity Pulsed Electromagnetic Fields (HI-PEMF) treatment is an emerging noninvasive and contactless alternative to conventional electroporation, since the electric field inside the tissue is induced remotely by an externally applied pulsed ...
Tamara Polajžer, Matej Kranjc, Vitalij Novickij, Damijan Miklavčič   +3 more
core   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Recognition of Elicitors in Grapevine: From MAMP and DAMP Perception to Induced Resistance

Frontiers in Plant Science, 2019
In a context of a sustainable viticulture, the implementation of innovative eco-friendly strategies, such as elicitor-triggered immunity, requires a deep knowledge of the molecular mechanisms underlying grapevine defense activation, from pathogen ...
Marie-Claire Héloir, Marielle Adrian, Daphnée Brulé, Justine Claverie, Sylvain Cordelier, Xavier Daire, Stéphan Dorey, Adrien Gauthier, Adrien Gauthier, Christelle Lemaître-Guillier, Jonathan Negrel, Lucie Trdá, Lucie Trdá, Sophie Trouvelot, Elodie Vandelle, Elodie Vandelle, Benoit Poinssot   +16 more
doaj   +1 more source

Emerging role of damage-associated molecular patterns derived from mitochondria in inflammation

, 2011
Cell death and injury often lead to release or exposure of intracellular molecules called damage-associated molecular patterns (DAMPs) or cell death-associated molecules.
Lambrecht, Bart, Claus Bachert, Bachert, Claus, Olga Krysko, Patrizia Agostinis, Krysko, Dmitri V., Krysko, Olga, Dmitri V. Krysko, Bart N. Lambrecht, Abhishek D. Garg, Vandenabeele, Peter, Garg, Abhishek, Agostinis, Patrizia, Garg, Abhishek D, Lambrecht, Bart N., Krysko, Dmitri, Peter Vandenabeele   +16 more
core   +1 more source