Results 61 to 70 of about 3,211,185 (261)

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Identification and fungicide screening of Phyllosticta capitalensis causing leaf spot on sweet viburnum in China

Phytopathologia Mediterranea
Sweet viburnum (Viburnum odoratissimum Ker-Gawl.) is a widely used ornamental plant, which has dense branches and leaves, and fast spreading and evergreen habit.
Wen LI, Yixuan RUAN, Zhengping BIAN, Yueqiu HE, Kai FENG, Liang LIU, Zhilong WANG, Feng HUANG   +7 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Development and evaluation of a multiplex molecular point-of-care assay for direct identification of Mycobacterium tuberculosis and prioritized non-tuberculous mycobacteria

Frontiers in Cellular and Infection Microbiology
ObjectiveThis study aimed to establish a multiplex molecular point-of-care assay called fastNTM incorporating an ultra-fast sample pre-treatment for direct identification of Mycobacterium tuberculosis complex (MTBC) and 8 non-tuberculous Mycobacteria ...
Qiao-Lian Yi, Yun Wu, Yun Wu, Shuang He, Meng-Li Feng, Xiao-Yu Liu, Xin-Zhu Zhou, Xin-Zhu Zhou, Hao-Tian Gao, Yu-Fan Zhang, Qi-Wen Yang, Qi-Wen Yang, Ying-Chun Xu, Ying-Chun Xu   +13 more
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Rapid identification of Rhodococcus equi by a PCR assay targeting the choE gene [PDF]

, 2003
The actinomycete Rhodococcus equi is an important pathogen of horses and an emerging opportunistic pathogen of humans. Identification of R. equi by classical bacteriological techniques is sometimes difficult, and misclassification of an isolate is not ...
Ladron, Nestor, Agüero, Jesús, González Zörn, Bruno, Fernandez, Marta, Navas, Jesus, Vazquez-Boland, Jose A   +5 more
core  

Rapid and accurate sepsis diagnostics via a novel probe-based multiplex real-time PCR system

Microbiology Spectrum
Sepsis is a critical clinical emergency that requires prompt diagnosis and intervention. Its prevalence has increased due to the aging population and increased antibiotic resistance. Early identification and the use of innovative technologies are crucial
Marco Favaro, Christian Fini, Maurizio Capannari, Ivano Petriccione, Claudia Rotondo, Assunta Navarra, Chiara Stellitano, Chiara De Giuli, Antonella Vulcano, Carla Fontana   +9 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Killing them softly:managing pathogen polymorphism and virulence in spatially variable environments [PDF]

, 2013
Understanding why pathogen populations are genetically variable is vital because genetic variation fuels evolution, which often hampers disease control efforts.
Vale, Pedro F; id_orcid, Vale, Pedro F.
core   +1 more source

Identification and Multigene Phylogenetic Analysis Reveal Alternaria as the Primary Pathogen Causing European Plum (Prunus domestica) Brown Spot in Xinjiang, China

Journal of Fungi
European plum (Prunus domestica) orchards in the Kashi region, Xinjiang, China, suffer from fruit brown spot disease. The disease typically appears as red spots on the fruit surface that expand into brown necrotic lesions; affected fruit flesh can shrink,
Shuaishuai Sha, Qiuyan Han, Hongyue Li, Wenwen Gao, Jiyuan Ma, Lingkai Xu, Canpeng Fu, Pan Xie   +7 more
doaj   +1 more source