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Study on the Correlation between Interleukin-27 and CXCL10 in Pulmonary Tuberculosis

open access: yesJournal of Immunology Research, 2022
Objective. To investigate the correlation between interleukin-27 and CXCL10 and other cytokines in pulmonary tuberculosis and to further explore the related miRNAs through bioinformatics. Methods.
Jiahui Fan   +9 more
doaj   +1 more source

Colonization of dermal arterioles by Neisseria meningitidis provides a safe haven from neutrophils

open access: yesNature Communications, 2021
The human pathogen Neisseria meningitidis colonizes blood vessels and causes vascular damage, despite a neutrophil-rich inflammatory infiltrate. Here, Manriquez et al.
Valeria Manriquez   +10 more
doaj   +1 more source

The pathogenesis of dengue [PDF]

open access: yesVaccine, 2011
Dengue is an important cause of childhood and adult morbidity in Asian and Latin American countries and its geographic footprint is growing. The clinical manifestations of dengue are the expression of a constellation of host and viral factors, some acquired, others intrinsic to the individual.
Whitehorn, J, Simmons, CP
openaire   +5 more sources

In vivo evolution of an emerging zoonotic bacterial pathogen in an immunocompromised human host

open access: yesNature Communications, 2021
Bordetella hinzii is an emerging pathogen with zoonotic risk to humans, known to be able to cause respiratory tract infection, bacteremia and endocarditis.
A. Launay   +5 more
doaj   +1 more source

A fine-tuned yeast surface-display/secretion platform enables the rapid discovery of neutralizing antibodies against Clostridioides difficile toxins

open access: yesMicrobial Cell Factories, 2023
Background Neutralizing antibody plays a key role in protecting hosts from invasive pathogens and their virulent components. Current high-throughput assays for antibody screening are based on binding activities.
Ying Sun   +6 more
doaj   +1 more source

Epstein-Barr virus infectious particles initiate B cell transformation and modulate cytokine response

open access: yesmBio, 2023
The Epstein-Barr virus (EBV) efficiently transforms primary B cells. Here, we show that this process starts immediately after cellular exposure to infectious viral particles.
Francesco Baccianti   +5 more
doaj   +1 more source

Astrovirus Pathogenesis [PDF]

open access: yesViruses, 2017
Astroviruses are a major cause of diarrhea in the young, elderly, and the immunocompromised. Since the discovery of human astrovirus type 1 (HAstV-1) in 1975, the family Astroviridae has expanded to include two more human clades and numerous mammalian and avian-specific genotypes. Despite this, there is still little known about pathogenesis.
Cydney Johnson   +4 more
openaire   +5 more sources

Progression of prostate cancer reprograms MYC-mediated lipid metabolism via lysine methyltransferase 2A

open access: yesDiscover Oncology, 2022
Background The activities of MYC, the androgen receptor, and its associated pioneer factors demonstrate substantial reprogramming between early and advanced prostate cancer.
Nichelle C. Whitlock   +14 more
doaj   +1 more source

Nontypeable Haemophilus influenzae released from biofilm residence by monoclonal antibody directed against a biofilm matrix component display a vulnerable phenotype

open access: yesScientific Reports, 2023
Bacterial biofilms contribute significantly to pathogenesis, recurrence and/or chronicity of the majority of bacterial diseases due to their notable recalcitrance to clearance.
Kathryn Q. Wilbanks   +5 more
doaj   +1 more source

Invasion of vaginal epithelial cells by uropathogenic Escherichia coli

open access: yesNature Communications, 2020
Uropathogenic E. coli can adhere to vaginal epithelial cells preceding urinary tract infection (UTI). Here, Brannon et al. show that urinary E. coli isolates can not only adhere to, but also invade vaginal cells in mouse UTI models and in clinical ...
John R. Brannon   +6 more
doaj   +1 more source

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