Results 1 to 10 of about 2,104,273 (219)

Study on the Correlation between Interleukin-27 and CXCL10 in Pulmonary Tuberculosis

Journal of Immunology Research, 2022
Objective. To investigate the correlation between interleukin-27 and CXCL10 and other cytokines in pulmonary tuberculosis and to further explore the related miRNAs through bioinformatics. Methods.
Jiahui Fan, Yefeng Yang, Liang Wang, Xiaoqian Shang, Li Zhang, Hu Sun, Yujie Ma, Ying Li, Jing Wang, Xiumin Ma   +9 more
doaj   +1 more source

Colonization of dermal arterioles by Neisseria meningitidis provides a safe haven from neutrophils

Nature Communications, 2021
The human pathogen Neisseria meningitidis colonizes blood vessels and causes vascular damage, despite a neutrophil-rich inflammatory infiltrate. Here, Manriquez et al.
Valeria Manriquez, Pierre Nivoit, Tomas Urbina, Hebert Echenique-Rivera, Keira Melican, Marie-Paule Fernandez-Gerlinger, Patricia Flamant, Taliah Schmitt, Patrick Bruneval, Dorian Obino, Guillaume Duménil   +10 more
doaj   +1 more source

In vivo evolution of an emerging zoonotic bacterial pathogen in an immunocompromised human host

Nature Communications, 2021
Bordetella hinzii is an emerging pathogen with zoonotic risk to humans, known to be able to cause respiratory tract infection, bacteremia and endocarditis.
A. Launay, C.-J. Wu, A. Dulanto Chiang, J.-H. Youn, P. P. Khil, J. P. Dekker   +5 more
doaj   +1 more source

Progression of prostate cancer reprograms MYC-mediated lipid metabolism via lysine methyltransferase 2A

Discover Oncology, 2022
Background The activities of MYC, the androgen receptor, and its associated pioneer factors demonstrate substantial reprogramming between early and advanced prostate cancer.
Nichelle C. Whitlock, Margaret E. White, Brian J. Capaldo, Anson T. Ku, Supreet Agarwal, Lei Fang, Scott Wilkinson, Shana Y. Trostel, Zhen-Dan Shi, Falguni Basuli, Karen Wong, Elaine M. Jagoda, Kathleen Kelly, Peter L. Choyke, Adam G. Sowalsky   +14 more
doaj   +1 more source

Epstein-Barr virus infectious particles initiate B cell transformation and modulate cytokine response

mBio, 2023
The Epstein-Barr virus (EBV) efficiently transforms primary B cells. Here, we show that this process starts immediately after cellular exposure to infectious viral particles.
Francesco Baccianti, Charlène Masson, Susanne Delecluse, Zhe Li, Remy Poirey, Henri-Jacques Delecluse   +5 more
doaj   +1 more source

A fine-tuned yeast surface-display/secretion platform enables the rapid discovery of neutralizing antibodies against Clostridioides difficile toxins

Microbial Cell Factories, 2023
Background Neutralizing antibody plays a key role in protecting hosts from invasive pathogens and their virulent components. Current high-throughput assays for antibody screening are based on binding activities.
Ying Sun, Yongrong Zhang, Hua Yu, Ashley Saint Fleur, Di Yu, Zhiyong Yang, Hanping Feng   +6 more
doaj   +1 more source

Nontypeable Haemophilus influenzae released from biofilm residence by monoclonal antibody directed against a biofilm matrix component display a vulnerable phenotype

Scientific Reports, 2023
Bacterial biofilms contribute significantly to pathogenesis, recurrence and/or chronicity of the majority of bacterial diseases due to their notable recalcitrance to clearance.
Kathryn Q. Wilbanks, Elaine M. Mokrzan, Theresa M. Kesler, Nikola Kurbatfinski, Steven D. Goodman, Lauren O. Bakaletz   +5 more
doaj   +1 more source

Yap governs a lineage-specific neuregulin1 pathway-driven adaptive resistance to RAF kinase inhibitors

Molecular Cancer, 2022
Background Inactivation of the Hippo pathway promotes Yap nuclear translocation, enabling execution of a transcriptional program that induces tissue growth.
Maria E. R. Garcia-Rendueles, Gnana Krishnamoorthy, Mahesh Saqcena, Adrian Acuña-Ruiz, Giovanna Revilla, Elisa de Stanchina, Jeffrey A. Knauf, Rona Lester, Bin Xu, Ronald A. Ghossein, James A. Fagin   +10 more
doaj   +1 more source

Invasion of vaginal epithelial cells by uropathogenic Escherichia coli

Nature Communications, 2020
Uropathogenic E. coli can adhere to vaginal epithelial cells preceding urinary tract infection (UTI). Here, Brannon et al. show that urinary E. coli isolates can not only adhere to, but also invade vaginal cells in mouse UTI models and in clinical ...
John R. Brannon, Taryn L. Dunigan, Connor J. Beebout, Tamia Ross, Michelle A. Wiebe, William S. Reynolds, Maria Hadjifrangiskou   +6 more
doaj   +1 more source

A Master Regulator of Bacteroides thetaiotaomicron Gut Colonization Controls Carbohydrate Utilization and an Alternative Protein Synthesis Factor

mBio, 2020
Microbial colonization of the mammalian gut is largely ascribed to the ability to utilize nutrients available in that environment. To understand how beneficial microbes establish a relationship with their hosts, it is crucial to determine what other ...
Guy E. Townsend, Weiwei Han, Nathan D. Schwalm, Xinyu Hong, Natasha A. Bencivenga-Barry, Andrew L. Goodman, Eduardo A. Groisman   +6 more
doaj   +1 more source