Results 41 to 50 of about 573,776 (343)

Viral pathogens [PDF]

Haemophilia, 2010
Summary.  Despite continuous improvement in safety and purity of blood products for individuals with haemophilia, transmissible agents continue to affect individuals with haemophilia. This chapter addresses three viral pathogens with significant clinical impact: HIV, hepatitis C and parvovirus B19.
M V, Ragni, K E, Sherman, J A, Jordan
openaire   +2 more sources

Antibiotics as a Stressing Factor Triggering the Harboring of Helicobacter pylori J99 within Candida albicans ATCC10231

Pathogens, 2021
First-line treatment for Helicobacter pylori includes amoxicillin and clarithromycin or metronidazole plus a proton pump inhibitor. Treatment failure is associated with antibiotic resistance and possibly also with internalization of H.
Kimberly Sánchez-Alonzo, Libnny Belmar, Cristian Parra-Sepúlveda, Humberto Bernasconi, Víctor L. Campos, Carlos T. Smith, Katia Sáez, Apolinaria García-Cancino   +7 more
doaj   +1 more source

The Dual Function of the Fungal Toxin Candidalysin during Candida albicans—Macrophage Interaction and Virulence

Toxins, 2020
The dimorphic fungus Candida albicans is both a harmless commensal organism on mucosal surfaces and an opportunistic pathogen. Under certain predisposing conditions, the fungus can overgrow the mucosal microbiome and cause both superficial and life ...
Annika König, Bernhard Hube, Lydia Kasper   +2 more
doaj   +1 more source

Lactobacillus rhamnosus colonisation antagonizes Candida albicans by forcing metabolic adaptations that compromise pathogenicity

Nature Communications, 2022
Commensal bacteria such as Lactobacillus rhamnosus can inhibit the pathogenicity of the fungus Candida albicans. Here, Alonso-Roman et al. investigate the interplay between C. albicans, L.
Raquel Alonso-Roman, Antonia Last, Mohammad H. Mirhakkak, Jakob L. Sprague, Lars Möller, Peter Großmann, Katja Graf, Rena Gratz, Selene Mogavero, Slavena Vylkova, Gianni Panagiotou, Sascha Schäuble, Bernhard Hube, Mark S. Gresnigt   +13 more
doaj   +1 more source

Chemical Characterization and Leishmanicidal Activity In Vitro and In Silico of Natural Products Obtained from Leaves of Vernonanthura brasiliana (L.) H. Rob (Asteraceae)

Metabolites, 2023
Vernonanthura brasiliana (L.) H. Rob is a medicinal plant used for the treatment of several infections. This study aimed to evaluate the antileishmanial activity of V. brasiliana leaves using in vitro and in silico approaches. The chemical composition of
Yuri Nascimento Fróes, João Guilherme Nantes Araújo, Joyce Resende dos Santos Gonçalves, Milena de Jesus Marinho Garcia de Oliveira, Gustavo Oliveira Everton, Victor Elias Mouchrek Filho, Maria Raimunda Chagas Silva, Luís Douglas Miranda Silva, Lucilene Amorim Silva, Lídio Gonçalves Lima Neto, Renata Mondêgo de Oliveira, Mylena Andréa Oliveira Torres, Luís Cláudio Nascimento da Silva, Alberto Jorge Oliveira Lopes, Amanda Silva dos Santos Aliança, Cláudia Quintino da Rocha, Joicy Cortez de Sá Sousa   +16 more
doaj   +1 more source

Evolutionary Dynamics of Giant Viruses and their Virophages [PDF]

, 2013
Giant viruses contain large genomes, encode many proteins atypical for viruses, replicate in large viral factories, and tend to infect protists. The giant virus replication factories can in turn be infected by so called virophages, which are smaller ...
Anderson, Beddington, Briggs, Claverie, Claverie, Claverie, Claverie, Colson, Culley, Desnues, Desnues, Desnues, Fischer, Fischer, Forterre, Gillespie, Herrero-Uribe, Hochberg, Holt, Iyer, Koonin, Krupovic, Lawrence, May, McCallum, Nowak, Pearson, Raoult, Raoult, Roy, Ruiz-Saenz, Scola, Scola, Scola, Sun, Suzan-Monti, Wodarz, Yamada, Yau, Zhang   +39 more
core   +2 more sources

An interspecies regulatory network inferred from simultaneous RNA-seq of Candida albicans invading innate immune cells

Frontiers in Microbiology, 2012
The ability to adapt to diverse micro-environmental challenges encountered within a host is of pivotal importance to the opportunistic fungal pathogen C. albicans. We have quantified C.albicans and M. musculus gene expression dynamics during phagocytosis
Lanay eTierney, Jörg eLinde, Sebastian eMüller, Sascha eBrunke, Sascha eBrunke, Juan Camilo Molina, Bernhard eHube, Bernhard eHube, Ulrike eSchöck, Reinhard eGuthke, Karl eKuchler   +10 more
doaj   +1 more source

The VirS/VirR two-component system regulates the anaerobic cytotoxicity, intestinal pathogenicity, and enterotoxemic lethality of Clostridium perfringens type C isolate CN3685. [PDF]

, 2011
Clostridium perfringens vegetative cells cause both histotoxic infections (e.g., gas gangrene) and diseases originating in the intestines (e.g., hemorrhagic necrotizing enteritis or lethal enterotoxemia).
Ma, Menglin, McClane, Bruce A, Saputo, Juliann, Uzal, Francisco, Vidal, Jorge   +4 more
core   +2 more sources

Uncharted territories in the discovery of antifungal and antivirulence natural products from bacteria

Computational and Structural Biotechnology Journal, 2021
Many fungi can cause deadly diseases in humans, and nearly every human will suffer from some kind of fungal infection in their lives. Only few antifungals are available, and some of these fail to treat intrinsically resistant species and the ever ...
Raghav Vij, Bernhard Hube, Sascha Brunke
doaj   +1 more source

In Vitro Incorporation of Helicobacter pylori into Candida albicans Caused by Acidic pH Stress

Pathogens, 2020
Yeasts can adapt to a wide range of pH fluctuations (2 to 10), while Helicobacter pylori, a facultative intracellular bacterium, can adapt to a range from pH 6 to 8. This work analyzed if H.
Kimberly Sánchez-Alonzo, Cristian Parra-Sepúlveda, Samuel Vega, Humberto Bernasconi, Víctor L. Campos, Carlos T. Smith, Katia Sáez, Apolinaria García-Cancino   +7 more
doaj   +1 more source