Results 41 to 50 of about 210,770 (100)

Candida albicans Hyphal Expansion Causes Phagosomal Membrane Damage and Luminal Alkalinization

mBio, 2018
Macrophages rely on phagosomal acidity to destroy engulfed microorganisms. To survive this hostile response, opportunistic fungi such as Candida albicans developed strategies to evade the acidic environment. C. albicans is polymorphic and able to convert
Johannes Westman, Gary Moran, Selene Mogavero, Bernhard Hube, Sergio Grinstein   +4 more
doaj   +1 more source

Evaluation of the Antibacterial and Antifungal Potential of Peltophorum africanum: Toxicological Effect on Human Chang Liver Cell Line

The Scientific World Journal, 2013
We assessed the in vitro antimicrobial activity of Peltophorum africanum by means of the agar well and macrodilution methods. The toxicity on a normal human liver cell (Chang liver cell) was determined using the CellTiter-Blue cell viability assay, and ...
Benjamin I. Okeleye, Noxolo T. Mkwetshana, Roland N. Ndip   +2 more
doaj   +1 more source

A doubly robust estimator for continuous treatments in high dimensions

BMC Medical Research Methodology
Background Generalized propensity score (GPS) methods have become popular for estimating causal relationships between a continuous treatment and an outcome in observational studies with rich covariate information. The presence of rich covariates enhances
Qian Gao, Jiale Wang, Ruiling Fang, Hongwei Sun, Tong Wang   +4 more
doaj   +1 more source

Association of exposure to multiple perfluoroalkyl and polyfluoroalkyl substances and glucose metabolism in National Health and Nutrition Examination Survey 2017–2018

Frontiers in Public Health
ObjectiveTo investigate the relationships between perfluoroalkyl and polyfluoroalkyl substances (PFASs) exposure and glucose metabolism indices.MethodsData from the National Health and Nutrition Examination Survey (NHANES) 2017–2018 waves were used.
Qinghua Tian, Qinghua Tian, Yutong Yang, Yutong Yang, Qi An, Qi An, Yang Li, Yang Li, Qingyao Wang, Qingyao Wang, Ping Zhang, Ping Zhang, Yue Zhang, Yue Zhang, Yingying Zhang, Yingying Zhang, Lina Mu, Lijian Lei, Lijian Lei   +18 more
doaj   +1 more source

Keeping Candida commensal: how lactobacilli antagonize pathogenicity of Candida albicans in an in vitro gut model

Disease Models & Mechanisms, 2019
The intestine is the primary reservoir of Candida albicans that can cause systemic infections in immunocompromised patients. In this reservoir, the fungus exists as a harmless commensal. However, antibiotic treatment can disturb the bacterial microbiota,
Katja Graf, Antonia Last, Rena Gratz, Stefanie Allert, Susanne Linde, Martin Westermann, Marko Gröger, Alexander S. Mosig, Mark S. Gresnigt, Bernhard Hube   +9 more
doaj   +1 more source

Development of an alcoholic liver disease model for drug evaluation from human induced pluripotent stem cell-derived liver organoids

Acta Biochimica et Biophysica Sinica
Alcoholic liver disease (ALD) poses a significant health challenge, so comprehensive research efforts to improve our understanding and treatment strategies are needed.
Feng Zhiwei, Zhou Bingrui, Shuai Qizhi, Wei Yunliang, Jin Ning, Wang Xiaoling, Zhao Hong, Liu Zhizhen, Xu Jun, Mu Jianbing, Xie Jun   +10 more
doaj   +1 more source

A review of common statistical methods for dealing with multiple pollutant mixtures and multiple exposures

Frontiers in Public Health
Traditional environmental epidemiology has consistently focused on studying the impact of single exposures on specific health outcomes, considering concurrent exposures as variables to be controlled.
Guiming Zhu, Guiming Zhu, Yanchao Wen, Yanchao Wen, Kexin Cao, Kexin Cao, Simin He, Simin He, Tong Wang, Tong Wang   +9 more
doaj   +1 more source

Inflammation-targeted delivery of Urolithin A mitigates chemical- and immune checkpoint inhibitor-induced colitis

Journal of Nanobiotechnology
Inflammatory bowel disease (IBD) treatment often involves systemic administration of anti-inflammatory drugs or biologics such as anti-TNF-α antibodies. However, current drug therapies suffer from limited efficacy due to unresponsiveness and adverse side
Sweta Ghosh, Rajbir Singh, Tanu Jain Goap, Omprakash Sunnapu, Zachary M. Vanwinkle, Hong Li, Syam P. Nukavarapu, Gerald W. Dryden, Bodduluri Haribabu, Praveen Kumar Vemula, Venkatakrishna Rao Jala   +10 more
doaj   +1 more source

Engineered in vivo and in vitro tumor model recapitulates vasculogenic mimicry signatures in melanoma

Bioengineering & Translational Medicine
Vasculogenic mimicry (VM) describes a process by which tumor cells formed a novel microcirculation pattern in an endothelial cell‐free manner. Clinically, VM is associated with aggressive phenotype and poor patient survival.
Qizhi Shuai, Xinrui Xu, Yuxiang Liang, Zulala Halbiyat, Xin Lu, Zixuan Hu, Zhiwei Peng, Jie An, Zhiwei Feng, Tingjuan Huang, Hong Zhao, Zhizhen Liu, Jun Xu, Jun Xie   +13 more
doaj   +1 more source

A Bayesian network for estimating hypertension risk due to occupational aluminum exposure

Chronic Diseases and Translational Medicine
Background The correlation between metals and hypertension, such as sodium, zinc, potassium, and magnesium, has been confirmed, while the relationship between aluminum and hypertension is not very clear.
Le Zhao, Jinzhu Yin, Jiaping Huan, Xiao Han, Dan Zhao, Jing Song, Linping Wang, Huifang Zhang, Baolong Pan, Qiao Niu, Xiaoting Lu   +10 more
doaj   +1 more source