Results 51 to 60 of about 455,752 (296)

Pathophysiology, histopathology and therapeutic of SARS-CoV-2 [PDF]

, 2020
The rapid transmission of SARS-CoV-2 through the world has induced the scientist to understand the histopathology of the virus and then to find an effective drug.
Al-Gheethi, Adel, Al-Shorgani, Najeeb, Hezam, Kamal, Noman, Efaq, Othman, Norzila, Radin Mohamed, Radin Maya Saphira, Talip, Balkis   +6 more
core  

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

The Equal Neutralizing Effectiveness of BNT162b2, ChAdOx1 nCoV-19, and Sputnik V Vaccines in the Palestinian Population

Vaccines
Since the beginning of the COVID-19 pandemic, different viral vector-based and mRNA vaccines directed against the SARS-CoV-2 “S” spike glycoprotein have been developed and have shown a good profile in terms of safety and efficacy.
Alexia Damour, Muriel Faure, Nicolas Landrein, Jessica Ragues, Narda Ardah, Haneen Dhaidel, Marie-Edith Lafon, Harald Wodrich, Walid Basha   +8 more
doaj   +1 more source

Cytochrome P450 1A1 is essential for the microbial metabolite, Urolithin A-mediated protection against colitis

Frontiers in Immunology, 2022
BackgroundCytochrome P450 Family 1 Subfamily A Member 1 (CYP1A1) pathway, which is regulated by aryl hydrocarbon receptor (AhR) plays an important role in chemical carcinogenesis and xenobiotic metabolism.
Sweta Ghosh, Bhagavatula Moorthy, Bodduluri Haribabu, Venkatakrishna Rao Jala   +3 more
doaj   +1 more source

Candida albicans pathogenicity mechanisms [PDF]

, 2013
Peer reviewedPublisher ...
Alonso-Monge R, Braun BR, Csank C, De Bernardis F, Diez-Orejas R, Fonzi WA, Hube B, Hwang CS, Mühlschlegel FA, Sorger PK, Wysong DR   +10 more
core   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Use of the Fluorescent Dye Thioflavin T to Track Amyloid Structures in the Pathogenic Yeast Candida albicans

Bio-Protocol
The human pathogenic yeast Candida albicans can attach to epithelial cells or indwelling medical devices to form biofilms. These microbial communities are highly problematic in the clinic as they reduce both sensitivity to antifungal drugs and detection ...
Thierry Mourer, Christophe d'Enfert, Sophie Bachellier-Bassi   +2 more
doaj   +1 more source

Pathogenicity of anti-ADAMTS13 autoantibodies in acquired thrombotic thrombocytopenic purpura. [PDF]

, 2015
BACKGROUND: Acquired thrombotic thrombocytopenic purpura (TTP) is an autoimmune disease in which anti-ADAMTS13 autoantibodies cause severe enzyme deficiency.
Crawley, JT, De Groot, R, Scully, MA, Thomas, MR   +3 more
core   +2 more sources

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Evolutionary Dynamics of Giant Viruses and their Virophages [PDF]

, 2013
Giant viruses contain large genomes, encode many proteins atypical for viruses, replicate in large viral factories, and tend to infect protists. The giant virus replication factories can in turn be infected by so called virophages, which are smaller ...
Anderson, Beddington, Briggs, Claverie, Claverie, Claverie, Claverie, Colson, Culley, Desnues, Desnues, Desnues, Fischer, Fischer, Forterre, Gillespie, Herrero-Uribe, Hochberg, Holt, Iyer, Koonin, Krupovic, Lawrence, May, McCallum, Nowak, Pearson, Raoult, Raoult, Roy, Ruiz-Saenz, Scola, Scola, Scola, Sun, Suzan-Monti, Wodarz, Yamada, Yau, Zhang   +39 more
core   +2 more sources