Results 111 to 120 of about 4,236 (237)
A call for action: Closing the evidence gap in management of stimulant‐induced psychosis
Addiction, EarlyView.Abstract Background Stimulant‐induced psychosis (StIP) is emerging as one of most pressing health challenges. Over the past two decades, stimulant‐related harms and psychiatric care demands have risen sharply. Individuals with StIP often present with severe agitation and high suicide risk, and up to half progress to chronic psychotic illness within two
Anne Bouthillier +3 more
wiley +1 more source
What political theory can learn from conceptual engineering: The case of “corruption”
American Journal of Political Science, EarlyView.Abstract Conceptual change is commonplace in political theory. Recent scholarship argues that improving a concept, or “engineering” it, can sharpen its normative and explanatory power. This article illustrates what political theory can learn from conceptual engineering (CE) by examining the evolution of “corruption” as a case study.
Emanuela Ceva, Patrizia Pedrini
wiley +1 more source
Allergy, EarlyView.ABSTRACT Background Allergic rhinitis (AR) impacts quality of life, work and school productivity. Over the last years, an important body of evidence resulting from mHealth data has led to a better understanding of AR. Such advances have motivated an EAACI‐endorsed update of the Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines (ARIA 2024 ...
Bernardo Sousa‐Pinto +252 more
wiley +1 more source
Acta Ophthalmologica, EarlyView.Abstract Purpose To investigate the diagnostic performance of ultrasound, 2‐deoxy‐2‐[18F]fluoro‐D‐glucose positron emission tomography/computed tomography (2‐[18F]FDG PET/CT) and temporal artery biopsy (TAB) in giant cell arteritis (GCA). Methods This was a prospective single‐centre diagnostic accuracy study (ClinicalTrials.gov NCT05248906).
Michael S. Hansen +10 more
wiley +1 more source
Alterations of gray matter asymmetry in internet gaming disorder
Scientific ReportsStructural asymmetry is a subtle but pervasive property of the human brain, which has been found altered in various psychiatric and neurocognitive disorders.
Shuaiyu Chen +8 more
doaj +1 more source
Predictors of depressive symptoms and depression in women with previous pregnancy loss
British Journal of Clinical Psychology, EarlyView.Abstract Objectives Depressive symptoms are common in females after pregnancy loss. However, research on risk factors for developing a clinical depressive episode remains limited and with inconsistent findings. This study examined the association of demographic variables (like age), pregnancy‐related factors (like number of miscarriages or stillbirths),
Sarah M. Quaatz +6 more
wiley +1 more source
BJU International, EarlyView.Objectives To provide a comprehensive summary of the surgical outcomes of Zephyr Surgical Implants (ZSI; Geneva, Switzerland) hydraulic and malleable female‐to‐male (FTM) penile implants (PIs) in transgender patients. Patients and Methods All transgender patients who underwent hydraulic (ZSI FTM 475) and malleable (ZSI FTM 100) erectile device ...
Maya Levy +6 more
wiley +1 more source
British Journal of Pharmacology, EarlyView.Theorized mechanism of dopamine homeostasis restoration in the nucleus accumbens core induced by a psychedelic intervention. Abstract Psychedelics have garnered great attention in recent years as treatments for major depressive disorder (MDD) and treatment‐resistant depression because of their ability to alter consciousness and afflicted cognitive ...
Lucas Wittenkeller +3 more
wiley +1 more source
PDE4D and PDE3B orchestrate distinct cAMP microdomains in 3T3‐L1 adipocytes
British Journal of Pharmacology, EarlyView.Basal conditions: •Ins/PDE3B lowers cytoplasmic cAMP (cyt‐cAMP) without affecting plasma membrane cAMP (pm‐cAMP). •Insulin decreases lipid droplet cAMP (LD‐cAMP) independent of PDE3B. •FGF1/PDE4D modestly reduces both cyt‐ and pm‐cAMP, while PDE4D alone can modulate LD‐cAMP. ISO stimulation: •Ins/PDE3B has minimal impact on cyt‐cAMP.
Johannes Krier +9 more
wiley +1 more source
Targeting protein–protein interactions with reversible covalent modalities: Non‐cysteine chemistries
British Journal of Pharmacology, EarlyView.Abstract Protein–protein interactions (PPIs) are central to diverse cellular functions, and represent a rapidly expanding class of therapeutic targets. Advancements in covalent drug design have enabled small‐molecule drugs to overcome challenges associated with engaging these targets, such as limited durations of action and difficult‐to‐drug (expansive,
Ruchira Basu, Steven Fletcher
wiley +1 more source