Results 21 to 30 of about 940,129 (290)

Urinary Transthyretin as a Biomarker in ATTRv Val50Met Amyloidosis

Pathophysiology, 2022
Transthyretin (TTR), the precursor protein for amyloidogenic TTR (ATTR) amyloidosis, forms tetramers and escapes glomerular filtration by binding with thyroxine and retinol-binding protein.
Hiroaki Matsushita, Yohei Misumi, Teruaki Masuda, Masamitsu Okada, Fumika Inoue, Mitsuharu Ueda, Yukio Ando   +6 more
doaj   +1 more source

Role of gut microbiota in type 2 diabetes pathophysiology

EBioMedicine, 2020
A substantial body of literature has provided evidence for the role of gut microbiota in metabolic diseases including type 2 diabetes. However, reports vary regarding the association of particular taxonomic groups with disease. In this systematic review,
M. Gurung, Zhipeng Li, H. You, R. Rodrigues, D. Jump, A. Morgun, N. Shulzhenko   +6 more
semanticscholar   +1 more source

Pathophysiology and mechanism of long COVID: a comprehensive review

Annals medicus, 2022
Background After almost 2 years of fighting against SARS-CoV-2 pandemic, the number of patients enduring persistent symptoms long after acute infection is a matter of concern.
D. Castanares-Zapatero, P. Chalon, L. Kohn, M. Dauvrin, J. Detollenaere, C. Maertens de Noordhout, C. Primus-de Jong, I. Cleemput, K. Van den Heede   +8 more
semanticscholar   +1 more source

High Sucrose and Cholic Acid Diet Triggers PCOS-like Phenotype and Reduces Enterobacteriaceae Colonies in Female Wistar Rats

Pathophysiology, 2022
Polycystic ovary syndrome (PCOS), a common hormonal disorder in women of reproductive age, is associated with a poor and unhealthy diet. This study aimed to investigate the effect of a high sucrose and cholic acid (HSCA) diet in the presence of PCOS-like
I Made Putra Juliawan, Febie Putra Suwana, Jimmy Yanuar Annas, Muhammad Firman Akbar, Widjiati Widjiati   +4 more
doaj   +1 more source

Chronic Fatigue Exhibits Heterogeneous Autoimmunity Characteristics Which Reflect Etiology

Pathophysiology, 2022
Chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) is considered to be associated with post-viral complications and mental stress, but the role of autoimmunity also remains promising.
Olga V. Danilenko, Natalia Y. Gavrilova, Leonid P. Churilov   +2 more
doaj   +1 more source

Lifestyle, Oxidative Stress, and Antioxidants: Back and Forth in the Pathophysiology of Chronic Diseases

Frontiers in Physiology, 2020
Oxidative stress plays an essential role in the pathogenesis of chronic diseases such as cardiovascular diseases, diabetes, neurodegenerative diseases, and cancer. Long term exposure to increased levels of pro-oxidant factors can cause structural defects
M. Sharifi-Rad, N. V. Anil Kumar, P. Zucca, E. Varoni, L. Dini, E. Panzarini, J. Rajković, P. T. Tsouh Fokou, E. Azzini, I. Peluso, Abhay Prakash Mishra, M. Nigam, Youssef El Rayess, M. Beyrouthy, L. Polito, M. Iriti, N. Martins, M. Martorell, A. Docea, W. Setzer, D. Calina, W. Cho, Javad Sharifi‐Rad   +22 more
semanticscholar   +1 more source

Takotsubo Syndrome: Pathophysiology, Emerging Concepts and Clinical Implications

Circulation, 2022
Takotsubo syndrome is a condition characterized by acute transient left ventricular systolic dysfunction, which at presentation can be challenging to distinguish from acute myocardial infarction.
T. Singh, H. Khan, D. Gamble, C. Scally, D. Newby, D. Dawson   +5 more
semanticscholar   +1 more source

Tuberculosis and Autoimmunity

Pathophysiology, 2022
Tuberculosis remains a common and dangerous chronic bacterial infection worldwide. It is long-established that pathogenesis of many autoimmune diseases is mainly promoted by inadequate immune responses to bacterial agents, among them Mycobacterium ...
Irina V. Belyaeva, Anna N. Kosova, Andrei G. Vasiliev   +2 more
doaj   +1 more source

Treatment Strategies for Chronic Coronary Heart Disease with Left Ventricular Systolic Dysfunction or Preserved Ejection Fraction—A Systematic Review and Meta-Analysis

Pathophysiology, 2023
In this meta-analysis, we examine the advantages of invasive strategies for patients diagnosed with chronic coronary heart disease (CHD) and preserved left ventricular (LV) function, as well as those with significant LV systolic dysfunction (LV ejection ...
Elena Zelikovna Golukhova, Inessa Viktorovna Slivneva, Olga Sergeevna Kozlova, Bektur Shukurbekovich Berdibekov, Ivan Ivanovich Skopin, Vadim Yuryevich Merzlyakov, Renat Kamilyevich Baichurin, Igor Yuryevich Sigaev, Milena Abrekovna Keren, Mikhail Durmishkhanovich Alshibaya, Damir Ildarovich Marapov, Milena Artemovna Arzumanyan   +11 more
doaj   +1 more source

CKD Urine Metabolomics: Modern Concepts and Approaches

Pathophysiology, 2023
One of the primary challenges regarding chronic kidney disease (CKD) diagnosis is the absence of reliable methods to detect early-stage kidney damage.
Elena Y. Danilova, Anna O. Maslova, Andrey N. Stavrianidi, Alexander E. Nosyrev, Larisa D. Maltseva, Olga L. Morozova   +5 more
doaj   +1 more source