Results 31 to 40 of about 850,363 (310)

The Role of AP-1 Transcription Factors in Plasma Cell Biology and Multiple Myeloma Pathophysiology

, 2021
Multiple myeloma (MM) is an incurable hematologic malignancy characterized by the clonal expansion of malignant plasma cells within the bone marrow. Activator Protein-1 (AP-1) transcription factors (TFs), comprised of the JUN, FOS, ATF and MAF multigene ...
Klaus Podar, Fengjuan Fan
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The Angiotensin-Converting Enzyme Inhibitor Lisinopril Mitigates Memory and Motor Deficits in a Drosophila Model of Alzheimer’s Disease

Pathophysiology, 2021
The use of angiotensin-converting enzyme inhibitors (ACEis) has been reported to reduce symptoms of cognitive decline in patients with Alzheimer’s disease (AD). Yet, the protective role of ACEis against AD symptoms is still controversial.
Jimiece Thomas, Haddon Smith, C. Aaron Smith, Lori Coward, Gregory Gorman, Maria De Luca, Patricia Jumbo-Lucioni   +6 more
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Is an Immunosuppressive Microenvironment a Characteristic of Both Intra- and Extraparenchymal Central Nervous Tumors?

Pathophysiology, 2021
In spite of intensive research, the survival rates of patients diagnosed with tumors of the central nervous system (CNS) have not improved significantly in the last decade.
Amina Soltani, Bela Kajtar, El Husseiny Mohamed Mahmud Abdelwahab, Anita Steib, Zsolt Horvath, Laszlo Mangel, Luca Jaromi, Judit E. Pongracz   +7 more
doaj   +1 more source

Pathophysiology: Altered Physiological States

, 2018
Pathophysiology is the convergence of pathology (the discipline of observed changes in a diseased state) with physiology (the mechanisms of systems operation). It represents the functional changes that occur because of injury or disease.

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Eosinophilic esophagitis: From pathophysiology to treatment. [PDF]

, 2015
Eosinophilic esophagitis (EoE) is a chronic immune disease, characterized by a dense eosinophilic infiltrate in the esophagus, leading to bolus impaction and reflux-like symptoms. Traditionally considered a pediatric disease, the number of adult patients
SARNELLI, GIOVANNI, CUOMO, ROSARIO, D'ALESSANDRO, ALESSANDRA, PESCE, MARCELLA, Esposito, D, DE PALMA, GIOVANNI DOMENICO   +5 more
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A Clinical Trial for the Identification of Metabolic Biomarkers in Hashimoto’s Thyroiditis and in Psoriasis: Study Protocol

Pathophysiology, 2021
Hashimoto’s thyroiditis and psoriasis are inflammatory disorders that significantly impact patients’ quality of life, stressing the need for novel biomarkers of early diagnosis.
Evangelia Sarandi, Sabine Kruger Krasagakis, Dimitris Tsoukalas, Gottfried Rudofsky, Aristides Tsatsakis   +4 more
doaj   +1 more source

Current and Future Therapeutic Strategies for Limb Girdle Muscular Dystrophy Type R1: Clinical and Experimental Approaches

Pathophysiology, 2021
Limb girdle muscular dystrophy type R1 disease is a progressive disease that is caused by mutations in the CAPN3 gene and involves the extremity muscles of the hip and shoulder girdle. The CAPN3 protein has proteolytic and non-proteolytic properties. The
İzem Olcay Şahin, Yusuf Özkul, Munis Dündar   +2 more
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Editorial: The role of micronutrients in renal physiology and pathophysiology [PDF]

, 2023
Renal function is critical for normal physiology, and perturbations resulting in pathophysiology significantly impact not only renal function but homeostasis in the whole body.
Shadi K. Gholami, Hryciw, Deanne H, Hassan Askari, Jamshid Roozbeh, Askari, Hassan, Saraiva Camara, Niels Olsen, Niels Olsen Saraiva Camara, Gholami, Shadi K, Deanne H. Hryciw, Roozbeh, Jamshid   +9 more
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Pathophysiology of Lung Disease and Wound Repair in Cystic Fibrosis

Pathophysiology, 2021
Cystic fibrosis (CF) is an autosomal recessive, life-threatening condition affecting many organs and tissues, the lung disease being the chief cause of morbidity and mortality.
Massimo Conese, Sante Di Gioia
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Viral pathophysiology of multiple sclerosis: A role for Epstein-Barr virus infection?

, 2011
Multiple sclerosis (MS) is the most common inflammatory demyelinating and degenerative disease of the CNS. The cause of MS is unknown but environmental risk factors are implicated in MS.
Marta, M, Gavin Giovannoni, Maghzi, A-H, Isabel Bosca, Cosimo Maggiore, Monica Marta, Etemadifar, M, Ruth Dobson, Maggiore, C, Bosca, I, Masoud Etemadifar, Meier, U-C, Ute-Christiane Meier, Dobson, R, Giovannoni, G, Amir-Hadi Maghzi   +15 more
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