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Treatment Strategies for Chronic Coronary Heart Disease with Left Ventricular Systolic Dysfunction or Preserved Ejection Fraction—A Systematic Review and Meta-Analysis

open access: yesPathophysiology, 2023
In this meta-analysis, we examine the advantages of invasive strategies for patients diagnosed with chronic coronary heart disease (CHD) and preserved left ventricular (LV) function, as well as those with significant LV systolic dysfunction (LV ejection ...
Elena Zelikovna Golukhova   +11 more
doaj   +1 more source

CKD Urine Metabolomics: Modern Concepts and Approaches

open access: yesPathophysiology, 2023
One of the primary challenges regarding chronic kidney disease (CKD) diagnosis is the absence of reliable methods to detect early-stage kidney damage.
Elena Y. Danilova   +5 more
doaj   +1 more source

Pancreatic cancer cachexia: a review of mechanisms and therapeutics. [PDF]

open access: yes, 2014
Over the last decade, we have gained new insight into the pathophysiology of cachexia associated with pancreatic cancer. Unfortunately, its treatment is complex and remains a challenge.
Andrew Eugene Hendifar   +8 more
core   +2 more sources

sPAP/PAAT Ratio as a New Index of Pulmonary Vascular Load: A Study in Normal Subjects and Ssc Patients with and without PH

open access: yesPathophysiology, 2022
In pulmonary hypertension (PH), the development of right ventricular (RV) dilatation and RV failure are signs of accelerated progression of the disease, resulting in an increased risk of cardiac death.
Walter Serra, Alfredo Chetta
doaj   +1 more source

Diabetes mellitus and ischemic heart disease. the role of ion channels [PDF]

open access: yes, 2018
Diabetes mellitus is one the strongest risk factors for cardiovascular disease and, in particular, for ischemic heart disease (IHD). The pathophysiology of myocardial ischemia in diabetic patients is complex and not fully understood: some diabetic ...
De Marchis, Marialaura   +8 more
core   +2 more sources

Conservative Management of Spontaneous Left Main Coronary Artery Dissection (SCAD) Triggered by Emotional Stress in the Late Postpartum Period: Case Report and Pathophysiology

open access: yesPathophysiology, 2022
A spontaneous coronary artery dissection (SCAD) during the postpartum period is a serious medical emergency and the most important non-atherosclerotic cause of coronary artery disease (CAD) in this population. While conservative management is recommended
Jaksa Zanchi   +7 more
doaj   +1 more source

Stable coronary syndromes: pathophysiology, diagnostic advances and therapeutic need [PDF]

open access: yes, 2018
The diagnostic management of patients with angina pectoris typically centres on the detection of obstructive epicardial CAD, which aligns with evidence-based treatment options that include medical therapy and myocardial revascularisation.
Berry, Colin   +2 more
core   +1 more source

The Endothelial Glycocalyx and Retinal Hemodynamics

open access: yesPathophysiology, 2022
Purpose. Previous studies suggest that the endothelial glycocalyx adds to vascular resistance, inhibits thrombosis, and is critical for regulating homogeneous blood flow and ensuring uniform red blood cell (RBC) distribution. However, these functions and
Gaganpreet Kaur   +2 more
doaj   +1 more source

Serotonin and motherhood: From molecules to mood [PDF]

open access: yes, 2019
Emerging research points to a valuable role of the monoamine neurotransmitter, serotonin, in the display of maternal behaviors and reproduction-associated plasticity in the maternal brain.
Li, Ming   +2 more
core   +3 more sources

The Effect of TGFβ1 in Adipocyte on Inflammatory and Fibrotic Markers at Different Stages of Adipocyte Differentiation

open access: yesPathophysiology, 2022
Transforming growth factor beta (TGFβ) is a versatile cytokine. Although a profibrotic role of TGFβ is well established, its effect on tissue inhibitor of metalloproteinase (TIMPs) and inflammatory mediators are incompletely described.
Babu Raja Maharjan   +3 more
doaj   +1 more source

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