Results 51 to 60 of about 940,129 (290)

XV. Pneumocystosis pathophysiology [PDF]

FEMS Immunology & Medical Microbiology, 1998
Although immunodeficiency represents the main etiopathogenetic factor [1], the basic mechanism of Pneumocystis carinii pneumonia (PCP) pathogenesis remains poorly understood. When growing into alveoli, P. carinii interacts with cells and other components; the initial stages of PCP involve parasite attachment to alveolar epithelium, preferentially to ...
M C, Prévost, R, Escamilla, E M, Aliouat, N, Ceré, P, Coudert, E, Dei-Cas   +5 more
openaire   +2 more sources

Histologic Analysis of ‘Distraction Vaginogenesis’ in a Rat Model

Pathophysiology
Vaginal agenesis (VA) is frequently associated with mullerian agenesis. VA treatments include mechanical dilation and surgical vaginoplasty. We created a vaginal expansion sleeve (VES) as a novel device to progressively lengthen the vaginal canal.
Hannah Meyer, Lexus Trosclair, Sean D. Clayton, Collyn O’Quin, Carol Crochet, Joshua C. Colvin, Valerie Welch, Ahmed Alhaque, Giovanni Solitro, Mila Shah-Bruce, J. Steven Alexander, Donald L. Sorrells   +11 more
doaj   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Clinical Characteristics of 6102 Asymptomatic and Mild Cases for Patients with COVID-19 in Indonesia

Pathophysiology, 2023
Background: The COVID-19 pandemic has led to a rise in confirmed cases, making epidemiological studies crucial for identifying the source of transmission and developing effective treatment methods.
Erwin Astha Triyono, Joni Wahyuhadi, Christijogo Soemartono Waloejo, Dimas Aji Perdana, Nabilah, Sisilia Dewanti, Amal Arifi Hidayat, Michael Austin Pradipta Lusida, Fani Sarasati, Ngurah Arie Kapindra Dharma, Muhammad Ikhtiar Zaki Al Razzak, Tanri Hadinata Wiranegara, Nurarifah Destianizar Ali   +12 more
doaj   +1 more source

Spinal Cord Injury: Pathophysiology, Multimolecular Interactions, and Underlying Recovery Mechanisms

International Journal of Molecular Sciences, 2020
Spinal cord injury (SCI) is a destructive neurological and pathological state that causes major motor, sensory and autonomic dysfunctions. Its pathophysiology comprises acute and chronic phases and incorporates a cascade of destructive events such as ...
A. Anjum, Muhammad Da'in Yazid, Muhammad Fauzi Daud, Jalilah Idris, A. M. Ng, Amaramalar Selvi Naicker, Ohnmar Htwe Rashidah Ismail, Ramesh Kumar Athi Kumar, Y. Lokanathan   +8 more
semanticscholar   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Pathophysiology, Management, and Therapeutics in Subarachnoid Hemorrhage and Delayed Cerebral Ischemia: An Overview

Pathophysiology, 2023
Subarachnoid hemorrhage (SAH) is a type of hemorrhagic stroke resulting from the rupture of an arterial vessel within the brain. Unlike other stroke types, SAH affects both young adults (mid-40s) and the geriatric population.
Henry W. Sanicola, Caleb E. Stewart, Patrick Luther, Kevin Yabut, Bharat Guthikonda, J. Dedrick Jordan, J. Steven Alexander   +6 more
doaj   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Shift of N-MYC Oncogene Expression in AML Patients Carrying the FLT3-ITD Mutation

Pathophysiology, 2023
Mutations in the FLT3 gene not only lead to abnormalities in its structure and function, but also affect the expression of other genes involved in leukemogenesis.
Konstantin Bogdanov, Ekaterina Kudryavtseva, Yulia Fomicheva, Irina Churkina, Elza Lomaia, Larisa Girshova, Yuri Osipov, Andrey Zaritskey   +7 more
doaj   +1 more source

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

FEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López, Özge Yilmaz Ardicli, Mübeccel Akdis   +2 more
wiley   +1 more source