Results 31 to 40 of about 25,350,845 (291)

Pharmacogenetic Pathway Analysis of Irinotecan [PDF]

Clinical Pharmacology & Therapeutics, 2008
Irinotecan, a chemotherapeutic agent against various solid tumors, is a prodrug requiring activation to SN-38. Irinotecan's complex pharmacokinetics potentially allow for many genetic sources of variability. We explored relationships between pharmacokinetic pathways and polymorphisms in genes associated with irinotecan's metabolism and transport.
G L, Rosner, J C, Panetta, F, Innocenti, M J, Ratain   +3 more
openaire   +2 more sources

Identification of shared biological features in four different lung cell lines infected with SARS-CoV-2 virus through RNA-seq analysis

Frontiers in Genetics, 2023
The COVID-19 pandemic caused by SARS-CoV-2 has resulted in millions of confirmed cases and deaths worldwide. Understanding the biological mechanisms of SARS-CoV-2 infection is crucial for the development of effective therapies.
Xiaoxi Zhang, Seungjun Ahn, Seungjun Ahn, Peihua Qiu, Somnath Datta   +4 more
doaj   +1 more source

Urine Cell Transcriptomes Implicate Specific Renal Inflammatory Pathways Associated With Difficult‐to‐Control Hypertension

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2023
Background The renal mechanisms involved in the maintenance of human hypertension and resistance to treatment are not well understood. Animal studies suggest that chronic renal inflammation contributes to hypertension.
Kausik Umanath, Ruicong She, Clare Hassett, Indra Adrianto, Albert M. Levin, Gina Savickas, Jerry Yee, Pablo Ortiz   +7 more
doaj   +1 more source

Gene expression during testis development in Duroc boars

Animal, 2015
Androstenone is a steroid pheromone occurring in the pubertal Leydig cells. Breeding against androstenone can decrease pheromone odour in swine meat but appears to cause unwanted side effects such as delayed onset of puberty.
S. Lervik, A.B. Kristoffersen, L.N. Conley, I.C. Oskam, J. Hedegaard, E. Ropstad, I. Olsaker   +6 more
doaj   +1 more source

Phylogenetic Analysis of Metabolic Pathways [PDF]

Journal of Molecular Evolution, 2001
The information provided by completely sequenced genomes can yield insights into the multi-level organization of organisms and their evolution. At the lowest level of molecular organization individual enzymes are formed, often through assembly of multiple polypeptides. At a higher level, sets of enzymes group into metabolic networks.
C V, Forst, K, Schulten
openaire   +2 more sources

A Pathway Analysis Tool for Analyzing Microarray Data of Species with Low Physiological Information [PDF]

, 2008
Pathway information provides insight into the biological processes underlying microarray data. Pathway information is widely available for humans and laboratory animals in databases through the internet, but less for other species, for example, livestock.
Pas, M.F.W., te, M H Pool, Hulsegge, B., M F W Te Pas, B Hulsegge, J M J Rebel, Pool, M.H., S Van Hemert, Rebel, J.M.J., M A Smits, Hemert, S., van, Hoekman, A.J.W., A J W Hoekman, Smits, M.A.   +13 more
core   +1 more source

Subpathway Analysis based on Signaling-Pathway Impact Analysis of Signaling Pathway

PLOS ONE, 2015
Pathway analysis is a common approach to gain insight from biological experiments. Signaling-pathway impact analysis (SPIA) is one such method and combines both the classical enrichment analysis and the actual perturbation on a given pathway. Because this method focuses on a single pathway, its resolution generally is not very high because the ...
Xianbin Li, Liangzhong Shen, Xuequn Shang, Wenbin Liu   +3 more
openaire   +4 more sources

Pathway analysis of coronary atherosclerosis [PDF]

Physiological Genomics, 2005
Large-scale gene expression studies provide significant insight into genes differentially regulated in disease processes such as cancer. However, these investigations offer limited understanding of multisystem, multicellular diseases such as atherosclerosis.
Jennifer Y, King, Rossella, Ferrara, Raymond, Tabibiazar, Joshua M, Spin, Mary M, Chen, Allan, Kuchinsky, Aditya, Vailaya, Robert, Kincaid, Anya, Tsalenko, David Xing-Fei, Deng, Andrew, Connolly, Peng, Zhang, Eugene, Yang, Clifton, Watt, Zohar, Yakhini, Amir, Ben-Dor, Annette, Adler, Laurakay, Bruhn, Philip, Tsao, Thomas, Quertermous, Euan A, Ashley   +20 more
openaire   +2 more sources

Polymorphisms in circadian rhythm genes and the risk of differentiated thyroid cancer

Frontiers in Genetics
Introduction:Circadian rhythms are controlled by biological clocks regulated at the molecular level by a set of circadian genes operating through a negative feedback loop.
Takiy-Eddine Berrandou, Takiy-Eddine Berrandou, Emilie Cordina-Duverger, Claire Mulot, Anne-Valérie Guizard, Anne-Valérie Guizard, Claire Schvartz, Pierre Laurent-Puig, Monia Zidane, Florent De Vathaire, Pascal Guénel, Thérèse Truong   +11 more
doaj   +1 more source

C286, an orally available retinoic acid receptor β agonist drug, regulates multiple pathways to achieve spinal cord injury repair

Frontiers in Molecular Neuroscience
Retinoic acid receptor β2 (RARβ2) is an emerging therapeutic target for spinal cord injuries (SCIs) with a unique multimodal regenerative effect. We have developed a first-in-class RARβ agonist drug, C286, that modulates neuron-glial pathways to induce ...
Maria B. Goncalves, Yue Wu, Earl Clarke, John Grist, Julien Moehlin, Marco Antonio Mendoza-Parra, Carl Hobbs, Barret Kalindjian, Henry Fok, Adrian P. Mander, Hana Hassanin, Daryl Bendel, Jörg Täubel, Tim Mant, Thomas Carlstedt, Julian Jack, Jonathan P. T. Corcoran   +16 more
doaj   +1 more source