Results 11 to 20 of about 25,350,845 (291)
Pathway analysis: State of the art [PDF]
Frontiers in Physiology, 2015 Pathway analysis is a set of widely used tools for research in life sciences intended to give meaning to high-throughput biological data. The methodology of these tools settles in the gathering and usage of knowledge that comprise biomolecular ...
Miguel Angel eGarcía-Campos +4 more
doaj +3 more sources
Scientific Reports, 2022 AbstractThis paper introduces a pathway expression framework as an approach for constructing derived biomarkers. The pathway expression framework incorporates the biological connections of genes leading to a biologically relevant model. Using this framework, we distinguish between shedding subjects post-infection and all subjects pre-infection in human
Nathan Mankovich +3 more
openaire +3 more sources
Biological pathway analysis by ArrayUnlock and Ingenuity Pathway Analysis [PDF]
BMC Proceedings, 2009 Abstract Background Once a list of differentially expressed genes has been identified from a microarray experiment, a subsequent post-analysis task is required in order to find the main biological processes associated to the experimental system.
Jiménez-Marín, Ángeles +4 more
openaire +3 more sources
Dynamical pathway analysis [PDF]
BMC Systems Biology, 2008 Although a great deal is known about one gene or protein and its functions under different environmental conditions, little information is available about the complex behaviour of biological networks subject to different environmental perturbations. Observing differential expressions of one or more genes between normal and abnormal cells has been a ...
Hao Xiong, Yoonsuck Choe
openaire +3 more sources
Comparative analysis of the MAX pathway [PDF]
, 2012 The pattern of branch outgrowth is a key determinant of the plant body plan. In most angiosperms branching is flexible, as branches are produced from axillary meristems which can either remain dormant or grow out.
Hepworth, Joanna Alex
core +6 more sources
Pathway analysis of NAD+ metabolism [PDF]
Biochemical Journal, 2011 NAD+ is well known as a crucial cofactor in the redox balance of metabolism. Moreover, NAD+ is degraded in ADP-ribosyl transfer reactions, which are important components of multitudinous signalling reactions. These include reactions linked to DNA repair and aging.
de Figueiredo, Luis F. +3 more
openaire +3 more sources
Model simplification of signal transduction pathway networks via a hybrid inference strategy [PDF]
, 2008 A full-scale mathematical model of cellular networks normally involves a large number of variables and parameters. How to effectively develop manageable and reliable models is crucial for effective computation, analysis and design of such systems.
Hong Yue +5 more
core +4 more sources
Thermodynamic analysis of biodegradation pathways [PDF]
Biotechnology and Bioengineering, 2009 Abstract Microorganisms provide a wealth of biodegradative potential in the reduction and elimination of xenobiotic compounds in the environment. One useful metric to evaluate potential biodegradation pathways is thermodynamic feasibility. However, experimental data for the thermodynamic properties of xenobiotics is scarce.
Finley, Stacey D. +2 more
openaire +4 more sources
Sensitivity analysis and experimental design of a stiff signal transduction pathway model [PDF]
, 2007 Sensitivity analysis is normally used to analyze how sensitive a system is with respect to the change of parameters or initial conditions and is perhaps best known in systems biology via the formalism of metabolic control analysis [1, 2].
Yue, H. +4 more
core +3 more sources
PaxtoolsR: pathway analysis in R using Pathway Commons [PDF]
Bioinformatics, 2015 Abstract Purpose: PaxtoolsR package enables access to pathway data represented in the BioPAX format and made available through the Pathway Commons webservice for users of the R language to aid in advanced pathway analyses. Features include the extraction, merging and validation of pathway data represented in the BioPAX format.
Augustin Luna +4 more
openaire +3 more sources