Results 1 to 10 of about 25,350,845 (291)

Single-Molecule Chemistry Part II: Pathway Analysis of the Oxidation of Guanine to 8-Oxo-7,8-dihydroguanosine in an Oligonucleotide Hybrid [PDF]

Molecules
In a short 11 nt dye-labelled oligonucleotide hybrid, we investigated the oxidation of a single guanine, G, to 8-oxo-7,8-dihydroguanosine, 8oG, a reaction proceeding via two reaction pathways.
Jens Sobek, Marco Schmidt, Stephan Landgraf, Aaron Fleming, Kiyohiko Kawai, Ralph Schlapbach   +5 more
doaj   +2 more sources

Rare variants confer shared susceptibility to gastrointestinal tract cancer risk

Frontiers in Oncology, 2023
BackgroundCancers arising within the gastrointestinal tract are complex disorders involving genetic events that cause the conversion of normal tissue to premalignant lesions and malignancy.
Ji Zheng, Xin Wang, Xin Wang, Jingrao Li, Yuanna Wu, Jiang Chang, Junyi Xin, Junyi Xin, Meilin Wang, Meilin Wang, Meilin Wang, Tianpei Wang, Qingyi Wei, Qingyi Wei, Mengyun Wang, Mengyun Wang, Ruoxin Zhang, Ruoxin Zhang, Ruoxin Zhang   +18 more
doaj   +1 more source

Weighted Gene Coexpression Network Analysis Reveals Essential Genes and Pathways in Bipolar Disorder

Frontiers in Psychiatry, 2021
Bipolar disorder (BD) is a major and highly heritable mental illness with severe psychosocial impairment, but its etiology and pathogenesis remains unclear.
Zhen-Qing Zhang, Zhen-Qing Zhang, Wei-Wei Wu, Jin-Dong Chen, Guang-Yin Zhang, Jing-Yu Lin, Yan-Kun Wu, Yu Zhang, Yun-Ai Su, Ji-Tao Li, Tian-Mei Si   +10 more
doaj   +1 more source

Metabolic Profiles of Brassica juncea Roots in Response to Cadmium Stress

Metabolites, 2021
Brassica juncea has great application potential in phytoremediation of cadmium (Cd)-contaminated soil because of its excellent Cd accumulating and high biomass.
Piaopiao Tan, Chaozhen Zeng, Chang Wan, Zhe Liu, Xujie Dong, Jiqing Peng, Haiyan Lin, Mei Li, Zhixiang Liu, Mingli Yan   +9 more
doaj   +1 more source

RNA-Seq Analysis of Cisplatin and the Monofunctional Platinum(II) Complex, Phenanthriplatin, in A549 Non-Small Cell Lung Cancer and IMR90 Lung Fibroblast Cell Lines

Cells, 2020
Phenanthriplatin is a new monofunctional platinum(II) complex that binds only one strand of DNA and acts by blocking gene transcription, but its effect on gene regulation has not been characterized relative to the traditional platinum-based complex ...
Jerry D. Monroe, Satya A. Moolani, Elvin N. Irihamye, Joshua S. Speed, Yann Gibert, Michael E. Smith   +5 more
doaj   +1 more source

Comparison of Lysis and Detachment Sample Preparation Methods for Cultured Triple-Negative Breast Cancer Cells Using UHPLC–HRMS-Based Metabolomics

Metabolites, 2022
Dysregulation of cellular metabolism is now a well-recognized hallmark of cancer. Studies investigating the metabolic features of cancer cells have shed new light onto processes in cancer cell biology and have identified many potential novel treatment ...
Blake R. Rushing, Madison Schroder, Susan C. J. Sumner   +2 more
doaj   +1 more source

Control of Protein and Energy Metabolism in the Pituitary Gland in Response to Three-Week Running Training in Adult Male Mice

Cells, 2021
It is assumed that crosstalk of central and peripheral tissues plays a role in the adaptive response to physical activity and exercise. Here, we wanted to study the effects of training and genetic predisposition in a marathon mouse model on mRNA ...
Christina Walz, Julia Brenmoehl, Nares Trakooljul, Antonia Noce, Caroline Caffier, Daniela Ohde, Martina Langhammer, Klaus Wimmers, Siriluck Ponsuksili, Andreas Hoeflich   +9 more
doaj   +1 more source

Proteomic and Bioinformatic Investigation of Altered Pathways in Neuroglobin-Deficient Breast Cancer Cells

Molecules, 2021
Neuroglobin (NGB) is a myoglobin-like monomeric globin that is involved in several processes, displaying a pivotal redox-dependent protective role in neuronal and extra-neuronal cells. NGB remarkably exerts its function upon upregulation by NGB inducers,
Michele Costanzo, Marco Fiocchetti, Paolo Ascenzi, Maria Marino, Marianna Caterino, Margherita Ruoppolo   +5 more
doaj   +1 more source

Changes in Cerebrospinal Fluid Balance of TNF and TNF Receptors in Naïve Multiple Sclerosis Patients: Early Involvement in Compartmentalised Intrathecal Inflammation

Cells, 2021
An imbalance of TNF signalling in the inflammatory milieu generated by meningeal immune cell infiltrates in the subarachnoid space in multiple sclerosis (MS), and its animal model may lead to increased cortical pathology. In order to explore whether this
Roberta Magliozzi, Francesco Pezzini, Mairi Pucci, Stefania Rossi, Francesco Facchiano, Damiano Marastoni, Martina Montagnana, Giuseppe Lippi, Richard Reynolds, Massimiliano Calabrese   +9 more
doaj   +1 more source

Differential Expression Analysis Utilizing Condition-Specific Metabolic Pathways

Metabolites, 2023
Pathway analysis is ubiquitous in biological data analysis due to the ability to integrate small simultaneous changes in functionally related components.
Gianluca Mattei, Zhuohui Gan, Matteo Ramazzotti, Bernhard O. Palsson, Daniel C. Zielinski   +4 more
doaj   +1 more source