Results 101 to 110 of about 51,351 (304)

Clinical proteomics for precision medicine: the bladder cancer case [PDF]

, 2017
Precision medicine can improve patient management by guiding therapeutic decision based on molecular characteristics. The concept has been extensively addressed through the application of –omics based approaches.
Frantzi, Maria, Latosinska, Agnieszka, Merseburger, Axel S., Mischak, Harald, Vlahou, Antonia   +4 more
core   +1 more source

Patient-derived organoid models to decode liver pathophysiology

Trends in Endocrinology & Metabolism
Liver diseases represent a growing global health challenge, and the increasing prevalence of obesity and metabolic disorders is set to exacerbate this crisis. To meet evolving regulatory demands, patient-specific in vitro liver models are essential for understanding disease mechanisms and developing new therapeutic approaches.
Benjamin J. Dwyer, Janina E.E. Tirnitz-Parker   +1 more
openaire   +2 more sources

Translational Considerations for Injectable Biomaterials and Bioscaffolds to Repair and Regenerate Brain Tissue

Advanced Healthcare Materials, EarlyView.
The repair and regeneration of brain tissue faces both biological and technical challenges. Injectable bioscaffolds offer new opportunities to stimulate tissue regrowth in the brain by recruiting neural stem cells. Here, the translational issues are reviewed that need to be address to advance this promising new therapeutic approach from the bench to ...
Michel Modo, Alena Kisel
wiley   +1 more source

Methods and applications of patient-derived organoid models for immune microenvironment and immunotherapy research in multiple cancer types

Experimental Hematology & Oncology
Lack of pre-clinical models that simulate the complex TME and translate to human immunity is list as the top one challenge in the area of cancer immunotherapy development.
Yaya Yu, Yanan Li, Jiao Wang, Yanjuan Zhu, Zexin Zhang, Zhenzhen Xiao, Yadong Chen, Yanchun Qu, Ling Han, Haibo Zhang   +9 more
doaj   +1 more source

Morphological and Molecular Defects in Human Three-Dimensional Retinal Organoid Model of X-Linked Juvenile Retinoschisis [PDF]

, 2019
X-linked juvenile retinoschisis (XLRS), linked to mutations in the RS1 gene, is a degenerative retinopathy with a retinal splitting phenotype. We generated human induced pluripotent stem cells (hiPSCs) from patients to study XLRS in a 3D retinal organoid
Chang, Chia-Ching, Chen, Shih-Jen, Chien, Yueh, Chiou, Shih-Hwa, Huang, Kang-Chieh, Jane, Wann-Neng, Kuo, Jean-Cheng, Lu, Jyh-Feng, Nguyen, Phan Nguyen Nhi, Peng, Chi-Hsien, Schlaeger, Thorsten M., Shi, Michael, Tran, Audrey A., Tsai, Ping-Hsing, Wahlin, Karl J., Wang, Mong-Lien, Wang, Won-Jing, Yang, Tien-Chun, Yarmishyn, Aliaksandr A.   +18 more
core   +2 more sources

Modeling lung adenocarcinoma metastases using patient-derived organoids

Cell Reports Medicine
Approximately 50% of patients with surgically resected early-stage lung cancer develop distant metastasis. At present, there is no in vivo metastasis model to investigate the biology of human lung cancer metastases. Using well-characterized lung adenocarcinoma (LUAD) patient-derived organoids (PDOs), we establish an in vivo metastasis model that ...
Liu, Yuan, Lankadasari, Manendra, Rosiene, Joel, Johnson, Kofi E., Zhou, Juan, Bapat, Samhita, Chow-Tsang, Lai-Fong L., Tian, Huasong, Mastrogiacomo, Brooke, He, Di, Connolly, James G., Lengel, Harry B., Caso, Raul, Dunne, Elizabeth G., Fick, Cameron N., Rocco, Gaetano, Sihag, Smita, Isbell, James M., Bott, Mathew J., Li, Bob T., Lito, Piro, Brennan, Cameron W., Bilsky, Mark H., Rekhtman, Natasha, Adusumilli, Prasad S., Mayo, Marty W., Imielinski, Marcin, Jones, David R.   +27 more
openaire   +2 more sources

Computational Modeling Meets 3D Bioprinting: Emerging Synergies in Cardiovascular Disease Modeling

Advanced Healthcare Materials, EarlyView.
Emerging advances in three‐dimensional bioprinting and computational modeling are reshaping cardiovascular (CV) research by enabling more realistic, patient‐specific tissue platforms. This review surveys cutting‐edge approaches that merge biomimetic CV constructs with computational simulations to overcome the limitations of traditional models, improve ...
Tanmay Mukherjee, Mehdi Salar Amoli, Sarah Rezapourdamanab, Lama Rita El Shammas, Martin L. Tomov, Emilio A. Mendiola, Vahid Serpooshan, Reza Avazmohammadi   +7 more
wiley   +1 more source

Reliability of high-quantity human brain organoids for modeling microcephaly, glioma invasion and drug screening

Nature Communications
Brain organoids offer unprecedented insights into brain development and disease modeling and hold promise for drug screening. Significant hindrances, however, are morphological and cellular heterogeneity, inter-organoid size differences, cellular stress,
Anand Ramani, Giovanni Pasquini, Niklas J. Gerkau, Vaibhav Jadhav, Omkar Suhas Vinchure, Nazlican Altinisik, Hannes Windoffer, Sarah Muller, Ina Rothenaigner, Sean Lin, Aruljothi Mariappan, Dhanasekaran Rathinam, Ali Mirsaidi, Olivier Goureau, Lucia Ricci-Vitiani, Quintino Giorgio D’Alessandris, Bernd Wollnik, Alysson Muotri, Limor Freifeld, Nathalie Jurisch-Yaksi, Roberto Pallini, Christine R. Rose, Volker Busskamp, Elke Gabriel, Kamyar Hadian, Jay Gopalakrishnan   +25 more
doaj   +1 more source

Patient-derived gastric cancer organoids model heterogeneity and stroma-mediated chemoresistance in poorly cohesive carcinoma

Frontiers in Molecular Biosciences
ObjectiveGastric cancer (GC) remains a leading cause of cancer-related mortality, with poorly cohesive carcinoma (PCC) exhibiting rising incidence and poor therapeutic responses.
Yi Yin, Yi Yin, Shuhong Zeng, Shuhong Zeng, Shuhong Zeng, Hui Zhang, Hui Zhang, Shuangshuang Wang, Fei Ke, Qiang Rui, Jinyong Zhou, Yuwen Zhuang, Weixing Shen, Weixing Shen, Jun Qian, Jun Qian, Shenlin Liu, Shenlin Liu   +17 more
doaj   +1 more source

Patient and Disease-Specific Induced Pluripotent Stem Cells for Discovery of Personalized Cardiovascular Drugs and Therapeutics. [PDF]

, 2020
Human induced pluripotent stem cells (iPSCs) have emerged as an effective platform for regenerative therapy, disease modeling, and drug discovery.
Chandy, Mark, Paik, David T, Wu, Joseph C   +2 more
core