Results 111 to 120 of about 51,351 (304)

Bladder-cancer-associated mutations in RXRA activate peroxisome proliferator-activated receptors to drive urothelial proliferation [PDF]

, 2017
RXRA regulates transcription as part of a heterodimer with 14 other nuclear receptors, including the peroxisome proliferator-activated receptors (PPARs).
Arora, Vivek K, Bolzenius, Jennifer, Bowman, Gregory R, Chu, Clarence E, Halstead, Angela M, Kapadia, Chiraag D, Schriefer, Andrew, Wartman, Lukas D   +7 more
core   +2 more sources

Simvastatin Restores Uteroplacental Hemodynamics and Trophoblast Function in Obstetric Antiphospholipid Syndrome in a Placenta‐on‐a‐Chip Model

Advanced Healthcare Materials, EarlyView.
Simvastatin mitigates placental hypoperfusion in OAPS by ameliorating abnormal uteromaternal hemodynamics and enhancing trophoblast invasion via optimized endothelial cell interactions under pathological shear stress, as evidenced by results from a placenta‐on‐a‐chip platform.
Hongli Liu, Yuan Wang, Yanjun Cai, Ruixin Guo, Shunhua Liu, Tingting Chen, Tingting Sun, Ruiheng Huo, Tengwei Liu, Qingfeng Lv, Xietong Wang   +10 more
wiley   +1 more source

Advanced 3D Platforms for Modeling CNS Neuroinflammation: Cell Integration, Techniques, and Challenges

Advanced Healthcare Materials, EarlyView.
This review summarizes the roles of key central nervous system cell types, the extracellular matrix, and the blood‐brain barrier in neuroinflammation, and their integration into diverse 3D culture systems. It examines major incorporation strategies, including direct co‐culture, hydrogel encapsulation, transwell migration assays, and bioprinting ...
Emmanuelle D. Aiyegbusi, Julia Di Stefano, Dearbhaile Dooley   +2 more
wiley   +1 more source

Prospective pharmacotyping of urothelial carcinoma organoids for drug sensitivity prediction – feasibility and real world experience

Experimental Hematology & Oncology
Urothelial carcinoma (UC) of the urinary bladder has significant challenges in treatment due to its diverse genetic landscape and variable response to systemic therapy.
Michael Karl Melzer, Yanchun Ma, Jessica Lindenmayer, Clara Morgenstern, Felix Wezel, Friedemann Zengerling, Cagatay Günes, Nadine Therese Gaisa, Alexander Kleger, Christian Bolenz   +9 more
doaj   +1 more source

ETV2 Mediated Differentiation of Human Pluripotent Stem Cells Results in Functional Endothelial Cells for Engineering Advanced Vascularized Microphysiological Models

Advanced Healthcare Materials, EarlyView.
A robust method to generate functional human iPSC‐derived endothelial cells using inducible ETV2 expression. These cells self‐organize into stable, lumenized microvascular networks within microfluidic chips, surpassing conventional differentiation methods.
Shun Zhang, Zhengpeng Wan, Lei Wang, Caihong Wu, Junkai Zhang, Sarah Spitz, Xun Wang, Marie A. Floryan, Mark F. Coughlin, Francesca M. Pramotton, Liling Xu, Ron Weiss, Roger D. Kamm   +12 more
wiley   +1 more source

Organs to Cells and Cells to Organoids: The Evolution of in vitro Central Nervous System Modelling [PDF]

, 2019
With 100 billion neurons and 100 trillion synapses, the human brain is not just the most complex organ in the human body, but has also been described as “the most complex thing in the universe.” The limited availability of human living brain tissue for ...
Allende, Almeida, Amenduni, Ananiev, Auger, Avior, Awad, Baarine, Barral, Basuodan, Bershteyn, Bhinge, Biedler, Biedler, Bilican, Bird, Birey, Bousquet, Boza-Moran, Brammer, Brawner, Brewer, Bridget E. Bax, Brodal, Camp, Carlessi, Carpenter, Carter, Chamberlain, Chambers, Chandrasekaran, Chang, Chesselet, Clevers, Cohen, Conti, Corti, Costero, Coyle, Crain, Cugola, Cunningham, Curchoe, Dang, Dario Pacitti, Dawson, DeFelipe, Denham, Denton, Dezonne, Di Lullo, Dickinson, Diez del Corral, Dingle, Djuric, Doerr, Doers, Dotti, Ebert, Edri, Efthymiou, Egawa, Eigentler, Eiraku, Eiraku, Elston, Eyal, Fernandez-Santiago, Fietz, Filis, Foo, Franco, Frotscher, Fuller, Garcez, Gaspard, Ge, Gharib, Giandomenico, Giulian, Goldman, Goldstein, Golgi, Gomes, Gonzalez-Cordero, Gordon, Gotz, Greene, Griesi-Oliveira, Gähwiler, Halevy, Hall, Hansen, Harrison, Harrison, Hartung, Haubensak, Havlicek, Herculano-Houzel, Hick, Higuchi, Higurashi, Hoadley, Hogue, Hogue, Howard, Huang, Hughes, Iefremova, Imura, Itskovitz-Eldor, Jaenisch, Jakel, Janesick, Jang, Jiang, Jiao, Jo, Johns, Kadoshima, Kelava, Kelava, Kim, Kirkeby, Kleinman, Knopfel, Ko, Komssi, Kovalevich, Kuff, Lancaster, Lancaster, Lancaster, Lancaster, Lange, LaVail, Lavazza, Lee, Lee, Lee, Lee, Lee, LePage, Li, Liddelow, Lingor, Liu, Liu, Liu, Liu, Lohle, Lojewski, Ma, Maden, Mansour, Marchetto, Mariani, Mariani, Mastrangelo, Matsui, Mattei, McCarthy, McGivern, McKinney, Mellios, Miranda, Miranda, Miranda, Mishra, Miyata, Mohan, Monzel, Muguruma, Muotri, Nayler, Ng, Nguyen, Nizzardo, Nzou, Okita, Ostergaard, Pacitti, Pacitti, Pahlman, Panicker, Park, Park, Pasca, Pasca, Pasca, Patitucci, Pauklin, Paşca, Pekny, Petros, Pham, Pleasure, Puschmann, Puschmann, Qian, Quadrato, Raja, Ramón y Cajal, Ramón y Cajal, Ramón y Cajal, Ramón y Cajal, Renner, Reubinoff, Reynolds, Riccardo Privolizzi, Ricciardi, Ring, Robertson, Roth, Rowitch, Sakaguchi, Sanchez-Danes, Sareen, Schuldiner, Schwab, Schwartz, Schwartz, Serio, Shcheglovitov, Shepherd, Shi, Shi, Shipley, Siegenthaler, Sloan, Sneddon, Soldner, Stan, Stubbs, Suga, Sun, Sun, Sun, Sutcliffe, Tachibana, Takahashi, Tang, Temple, Thomson, Tian, Tibbitt, Tiscornia, Tonge, Trilck, Ullrich, Ungrin, Urbach, Uusi-Rauva, Velasco, Vescovi, Vessoni, Vierbuchen, Villanueva, Waddington, Waddington, Walsh, Wang, Watanabe, Wataya, Whetsell, Williams, Wilson, Wood, Workman, Wu, Xu, Yakoub, Yakoub, Yamashita, Yang, Yang, Ye, Yin, Ying, Yoshida, Zhang, Zhang, Zhang, Zhu, Zhu, Zhu   +285 more
core   +2 more sources

Enhanced Human Antigen‐Specific B Cell Responses Using In Vitro 3D Tonsil Cultures Containing Stromal Cells

Advanced Healthcare Materials, EarlyView.
We developed a fully human 3D tonsil cell culture system incorporating supportive stromal cells that better sustains and activates immune cells than conventional methods. The model generates stronger, more targeted antibody responses to viral antigens and vaccines, providing a physiologically relevant and entirely human platform for studying immune ...
Maaike V. J. Braham, Marlon de Gast, Liubov Babii, Sabine Kruijer, Theo M. Bestebroer, Mathilde Richard, Mathieu Claireaux, S. Marieke van Ham, Jelle de Wit, Cécile A. C. M. van Els, Anja ten Brinke, Marit J. van Gils   +11 more
wiley   +1 more source

Organoids as a model for colorectal cancer [PDF]

, 2016
Modelling human diseases in in vitro systems is undisputedly an invaluable research tool, yet there are many limitations. Some of those limitations have been overcome through the introduction of organoid culture systems, which have revolutionised ...
Reed, Karen Ruth, Young, Madeleine
core   +2 more sources

Mapping the Cerebral Organoid Landscape: A Systematic Review of Preclinical 3D Models in Neuroscience

Advanced Healthcare Materials, EarlyView.
Cerebral organoids are transforming brain research, yet the field remains fragmented. This comprehensive systematic review maps 738 studies published between 2014 and 2024 to uncover trends, gaps, and opportunities across neuroscience. Introducing OrganoidMap—an interactive, open‐access platform to explore and compare models—this work enables ...
Anna Wolfram, Vanessa Arnold, Maik Wolfram‐Schauerte, Anastassiya Moskalchuk, Caroline Trust, Marie Vontz, Mona Scheurenbrand, Vijayasarathy Sampath‐Kumar, Sogand Ahari, Carlos Romero‐Nieto, Lisa Sevenich   +10 more
wiley   +1 more source

Spontaneous Glioblastoma Spheroid Infiltration of Early-Stage Cerebral Organoids Models Brain Tumor Invasion. [PDF]

, 2018
Organoid methodology provides a platform for the ex vivo investigation of the cellular and molecular mechanisms underlying brain development and disease.
da Silva, B, Mathew, RK, Polson, ES, Williams, J, Wurdak, H   +4 more
core   +1 more source