Results 51 to 60 of about 3,156,311 (293)

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

open access: yesMolecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad   +2 more
wiley   +1 more source

SC DMH patient advocacy report November 2018

open access: yes, 2018
The Office of Patient Advocacy at the South Carolina Department of Mental Health publishes a monthly report with information on complaints resolved at agency centers and other statistics on the Office of Patient ...
South Carolina State Department of Mental Health, Office of Patient Advocacy
core   +1 more source

Patient-centred and fit-for-purpose clinical trials in rare cancers: lessons from sarcomas for operationalising 2024 WHO Guidance and ICH E6(R3)

open access: yesEClinicalMedicine
Summary: Rare cancers account for approximately one quarter of cancer diagnoses in Europe, yet prevailing clinical trial governance frameworks were developed for common malignancies and conventional randomised designs.
Ornella Gonzato   +4 more
doaj   +1 more source

Identifying barriers to patient advocacy in the promotion of a safety culture: An integrative review

open access: yesJournal of Perioperative Nursing, 2021
Problem identification: Promoting patient safety, through patient advocacy, is an important part of the perioperative nurse role. However, identified barriers to effective patient advocacy have also reflected deficits in the characteristics of safety ...
Teena Shoemark, Paula Foran
doaj   +1 more source

Effective Advocacy Evaluation: The Role of Funders [PDF]

open access: yes, 2009
· This article addresses the role of funders in supporting advocacy and advocacy evaluation work. · The growth and strengthening of the advocacy evaluation field has lessened the “hard to measure” stigma attached to advocacy grantmaking.
Johanna Morariu   +3 more
core   +1 more source

Understanding and Mitigating the Risk of Accelerated Biological Aging in Survivors of Cancer: A Scoping Review

open access: yesAging and Cancer, EarlyView.
Cancer treatment is associated with measurable acceleration of biological aging across epigenetic, telomere, senescence, and immune biomarkers. However, biomarker validation and interventional strategies remain limited, especially in hematologic malignancies, underscoring the need for standardized multi‐omic aging assessments and adequately powered ...
Moataz Ellithi   +3 more
wiley   +1 more source

Lived Experience and Patient Advocacy Module: Curriculum and Faculty Guide

open access: yesMedEdPORTAL, 2017
Introduction Medical teachers frequently tell learners how some of the greatest challenges in clinical care are not associated with the scientific details of biomedicine but are instead related to patient interactions and the human dimensions of illness ...
Laurie Gerber   +2 more
doaj   +1 more source

Call for Submissions - Special Issue July 2019: The Role of Technology and Innovation in Patient Experience [PDF]

open access: yes, 2018
Patient Experience Journal (PXJ) is excited to announce the call for submissions for its July 2019 special issue on the topic of the role of technology in patient & family experience.
Journal, Patient Experience   +1 more
core   +1 more source

RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu   +21 more
wiley   +1 more source

Resource utilization and multidisciplinary care needs for patients with Ehlers–Danlos syndrome

open access: yesMolecular Genetics & Genomic Medicine, 2022
Background Ehlers–Danlos syndrome (EDS) represents a family of heritable connective tissue disorders with overlapping phenotypic features, frequently including joint hypermobility, tissue fragility, and skin hyperextensibility.
Jordan T. Jones   +3 more
doaj   +1 more source

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