Results 71 to 80 of about 803,904 (364)

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

Molecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau, Hayley S. Smith, Begüm Alural, Claire E. Martin, Laura A. New, Manali Tilak, Sara L. Banerjee, Hannah N. Robeson, Nicolas Bisson, Anne‐Claude Gingras, Jasmin Lalonde, Nina Jones   +11 more
wiley   +1 more source

Validation of the Patient Activation Measure in a Multiple Sclerosis Clinic Sample and Implications for Care

, 2010
Purpose. Patient engagement in multiple sclerosis (MS) care can be challenging at times given the unpredictable disease course, wide range of symptoms, variable therapeutic response to treatment and high rates of patient depression. Patient activation, a
Hibbard, Judith, Hughes, Mary D, Johns, Lisa, Rutter Goodworth, Marie-Christine, Stepleman, Lara, Wright, Dustin   +5 more
core   +1 more source

Does the engagement of clinicians and organisations in research improve healthcare performance: a three-stage review [PDF]

, 2015
Objective: There is a widely held assumption that engagement by clinicians and healthcare organisations in research improves healthcare performance at various levels, but little direct empirical evidence has previously been collated.
Abraham, Bennett, Bernard, Boaz, Bowen, Carpenter, Chaney, Clarke, Cohen, Cooke, Darbyshire, Denis, Department of Health, Department of Health, Dixon-Woods, Du Bois, Ducharme, Francis, Goldberg, Greenhalgh, Hall, Hanney, Jagosh, Kizer, Kizer, Knudsen, Kuehlein, Laliberte, Lewin, Liberati, Lomas, Majumdar, Minasian, NHS Confederation, Oxman, Pincus, Pons, Puoane, Rich, Rochon, Rochon, Rogers, Selby, Smee, Soper, Spurgeon, Teal, Walshe, Whicher, Zerhouni   +49 more
core   +2 more sources

A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner

Molecular Oncology, EarlyView.
We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp, Wouter P. R. Verdurmen, Jonas V. Schaefer, Kari Kopra, Gabriela Nagy‐Davidescu, Elodie Richard, Marie‐Julie Nokin, Patrick Ernst, Rastislav Tamaskovic, Martin Schwill, Ralph Degen, Claudia Scholl, David Santamaria, Andreas Plückthun   +13 more
wiley   +1 more source

Factors affecting implementation of patient-reported outcome and experience measures in a pediatric health system

Journal of Patient-Reported Outcomes, 2023
Plain English summary Patient-reported outcome measures are standardized questionnaires that ask patients about their health and well-being and are useful for tracking patient progress and outcomes of care.
Erin McCabe, Sarah Rabi, Sumedh Bele, Jennifer D. Zwicker, Maria J. Santana   +4 more
doaj   +1 more source

Simultaneous inhibition of TRIM24 and TRIM28 sensitises prostate cancer cells to antiandrogen therapy, decreasing VEGF signalling and angiogenesis

Molecular Oncology, EarlyView.
TRIM24 and TRIM28 are androgen receptor (AR) coregulators which exhibit increased expression with cancer progression. Both TRIM24 and TRIM28 combine to influence the response of castrate‐resistant prostate cancer (CRPC) cells to AR inhibitors by mediating AR signalling, regulation of MYC and upregulating VEGF to promote angiogenesis. Castrate‐resistant
Damien A. Leach, Nilesh Chatterjee, Kellie Spahr, Gilberto Serrano de Almeida, Anabel Varela‐Carver, Taimur T. Shah, Mathias Winkler, Hashim U. Ahmed, Charlotte L. Bevan   +8 more
wiley   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Through Their Eyes: Using Photovoice to Capture the Capacity‐Building Journey of Long Covid Patient Experts

Health Expectations
Background Long Covid, characterised by persistent symptoms following the coronavirus disease 2019 (COVID‐19) infection, significantly impacts the quality of life.
Nabil Natafgi, Katie Parris, Erin Walker, Tracey Gartner, Jeanette Coffin, Ariana Mitcham, Luis Sanchez Ferrer, Maushmi K. Patel, Haley Wymbs, Ann Blair Kennedy   +9 more
doaj   +1 more source

People with lived experience (PWLE) of depression: describing and reflecting on an explicit patient engagement process within depression research priority setting in Alberta, Canada

Research Involvement and Engagement, 2018
Plain English summary The Alberta Depression Research Priority Setting Project aimed to meaningfully involve patients, families and clinicians in determining a research agenda aligned to the needs of Albertans who have experienced depression. The project
Lorraine J. Breault, Katherine Rittenbach, Kelly Hartle, Robbie Babins-Wagner, Catherine de Beaudrap, Yamile Jasaui, Emily Ardell, Scot E. Purdon, Ashton Michael, Ginger Sullivan, Aakai’naimsskai’piiaakii Sharon Ryder Unger, Lorin Vandall-Walker, Brad Necyk, Kiara Krawec, Elizabeth Manafò, Ping Mason-Lai   +15 more
doaj   +1 more source

Hidden in plain sight? Identifying patient-authored publications

Research Involvement and Engagement, 2022
Plain English summary Some patients are leading or helping with medical research to improve understanding of their condition and patient care. To share research findings, patients can author articles published in scientific journals.
Jacqui Oliver, Dawn Lobban, Laura Dormer, Joanne Walker, Richard Stephens, Karen Woolley   +5 more
doaj   +1 more source