Results 71 to 80 of about 633,152 (295)

The soluble pattern recognition receptor PTX3 links humoral innate and adaptive immune responses by helping marginal zone B cells

Journal of Experimental Medicine, 2016
Cerutti and collaborators show that the humoral arms of the innate and adaptive immune systems are functionally interconnected by pentraxin 3, a soluble pattern recognition receptor that couples innate immune recognition with antibody-inducing function.
Alejo Chorny, S. Casas-Recasens, J. Sintes, Meimei Shan, N. Polentarutti, R. García-Escudero, A. C. Walland, John R Yeiser, L. Cassis, J. Carrillo, Irene Puga, C. Cunha, C. Cunha, H. Bastos, H. Bastos, H. Bastos, Fernando Rodrigues, Fernando Rodrigues, J. Lacerda, António Morais, R. Dieguez‐Gonzalez, P. Heeger, G. Salvatori, A. Carvalho, A. Carvalho, A. García-Sastre, J. Blander, A. Mantovani, C. Garlanda, A. Cerutti   +29 more
semanticscholar   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Antecedent chromatin organization determines cGAS recruitment to ruptured micronuclei

Nature Communications, 2023
DNA damage-induced micronuclei are linked to downstream viral signalling through the cGAS pattern recognition receptor. Here, the authors identify features of micronuclei chromatin that determine cGAS-MN recruitment and associated pathway activation.
Kate M. MacDonald, Shirony Nicholson-Puthenveedu, Maha M. Tageldein, Sarika Khasnis, Cheryl H. Arrowsmith, Shane M. Harding   +5 more
doaj   +1 more source

Pattern Recognition Receptors and Infectious Diseases [PDF]

, 2012
Our bodies are under constant attack from pathogens. Despite this continual bombardment, under normal circumstances we remain healthy for most of our lives. This protection against infectious and harmful agents is provided by our immune system. The immune system can be broken into two elements: adaptive immunity and innate immunity.
Jopeace, Ardi Liaunardy, Howard, Chris B., Murton, Ben L., Edwards, Alexander D., Monie, Tom P.   +4 more
openaire   +3 more sources

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Bacterial Polysaccharide Specificity of the Pattern Recognition Receptor Langerin Is Highly Species-dependent*

Journal of Biological Chemistry, 2016
The recognition of pathogen surface polysaccharides by glycan-binding proteins is a cornerstone of innate host defense. Many members of the C-type lectin receptor family serve as pattern recognition receptors facilitating pathogen uptake, antigen ...
Jonas Hanske, J. Schulze, Jonas Aretz, Ryan McBride, B. Loll, Henrik Schmidt, Y. Knirel, W. Rabsch, M. Wahl, J. Paulson, C. Rademacher   +10 more
semanticscholar   +1 more source

The role and implications of mammalian cellular circadian entrainment

FEBS Letters, EarlyView.
At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley   +1 more source

Vitellogenin functions as a multivalent pattern recognition receptor with an opsonic activity. [PDF]

PLoS ONE, 2008
BACKGROUND: Vitellogenin (Vg), a major reproductive protein, has been associated with infection-resistant response in fish. However, the underlying mechanisms by which Vg is involved in anti-infectious response are not understood. METHODOLOGY/RESULTS: By
Zhaojie Li, Shicui Zhang, Qinghui Liu
doaj   +1 more source

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source