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The crosstalk between pattern-recognition receptor signaling and calcium signaling.
International Journal of Biological Macromolecules, 2021The innate immune system is the first line of host defense, and it is capable of resisting both exogenous pathogenic challenges and endogenous danger signals via different pattern recognition receptors (PRRs), including Toll-like receptors, retinoic acid-
Fanyun Kong +4 more
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Pattern recognition receptors in annelids
Developmental & Comparative Immunology, 2020The existence of pattern recognition receptors (PRRs) on immune cells was discussed in 1989 by Charles Janeway, Jr., who proposed a general concept of the ability of PRRs to recognize and bind conserved molecular structures of microorganisms known as pathogen-associated molecular patterns (PAMPs).
Prochazkova, P. +4 more
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Pattern recognition receptor‐mediated inflammation in diabetic vascular complications
Medicinal research reviews (Print), 2020The innate immune system contains multiple classes of pattern recognition receptors (PRRs), which recognize pathogen‐associated molecular patterns (PAMPs) and danger‐associated molecular patterns (DAMPs) in the intracellular and extracellular space ...
Xu Wang +4 more
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Pattern recognition receptors: an update
Expert Review of Clinical Immunology, 2006The vertebrate immune system consists of two inter-related components, the innate and adaptive responses, which are required for the resolution of infection. The innate immune response is critical for the immediate protection from infection and for marshalling the B- and T-cell responses of the adaptive response.
Goutagny, Nadege +1 more
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CD14 Is a pattern recognition receptor
Immunity, 1994Septic shock caused by a diverse group of bacterial pathogens is a serious human disease. Recognition of bacterial envelope constituents is one mechanism used by mammalian cells to initiate responses leading to bacterial killing or, unfortunately, responses that also cause fatal septic shock.
J, Pugin +8 more
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Pattern Recognition Receptors and Liver Failure
Critical Reviews in Immunology, 2019Liver failure is a clinical syndrome with many causes, a complicated pathogenesis, diverse clinical manifestations, and very high mortality. No effective treatment is yet available. Main pathological processes of liver failure include direct damage to parenchymal and nonparenchymal liver cells that might be caused by viruses or drugs, immune-mediated ...
Wu, Jun +7 more
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Regulation of pattern recognition receptor signalling by phosphorylation and ubiquitination.
Current opinion in plant biology, 2018Our understanding of how plant innate immunity is triggered and regulated has seen tremendous progress over the last decade, with many important players identified in the model systems Arabidopsis thaliana and Oryza sativa (rice). Identification of these
S. Mithoe, Frank L. H. Menke
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Identification and functions of pattern-recognition receptors
Journal of Allergy and Clinical Immunology, 2010Since the identification of Toll-like receptors, our knowledge about pattern-recognition receptors (PRRs) has increased rapidly. Classes of PRRs that have been recently discovered include RIG-I-like receptors, Nod-like receptors, and C-type lectin receptors.
Yutaro, Kumagai, Shizuo, Akira
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Expression of pattern recognition receptors in cholesteatoma
European Archives of Oto-Rhino-Laryngology, 2013Although many immunologic mechanisms have been investigated in studies of the pathogenesis of cholesteatoma, the role of pattern recognition receptors (PRRs) has not been fully determined. Therefore, we assessed innate immune responses in patients with cholesteatoma. We prospectively evaluated 21 patients with acquired cholesteatoma between August 2010
Ho Yun, Lee +4 more
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