Results 211 to 220 of about 188,478 (231)

Pattern recognition receptors: an update

Expert Review of Clinical Immunology, 2006
The vertebrate immune system consists of two inter-related components, the innate and adaptive responses, which are required for the resolution of infection. The innate immune response is critical for the immediate protection from infection and for marshalling the B- and T-cell responses of the adaptive response.
Goutagny, Nadege, Fitzgerald, Katherine A   +1 more
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Visualising pattern recognition receptor signalling

Biochemical Society Transactions, 2017
Signalling by pattern recognition receptors (PRRs) is critical for protecting the host against pathogens. Disruption of these signalling pathways has been implicated in many diseases ranging from infection susceptibility to cancer and autoimmune disease.
Charlotte, Macleod, Clare E, Bryant
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Pattern Recognition Receptors and Liver Failure

Critical Reviews in Immunology, 2019
Liver failure is a clinical syndrome with many causes, a complicated pathogenesis, diverse clinical manifestations, and very high mortality. No effective treatment is yet available. Main pathological processes of liver failure include direct damage to parenchymal and nonparenchymal liver cells that might be caused by viruses or drugs, immune-mediated ...
Wu, Jun, Han, Meihong, Li, Jia, Yang, Xiaoli, Zhen, Xin, Friedrich Schlaak, Joerg, Yang, Dongliang, Lu, Mengji   +7 more
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Antiviral Signaling Through Pattern Recognition Receptors

Journal of Biochemistry, 2006
Viral infection is detected by the host innate immune system. Innate immune cells such as dendritic cells and macrophages detect nucleic acids derived from viruses through pattern recognition receptors (PRRs). Viral recognition by PRRs initiates the activation of signaling pathways that lead to production of type I interferon and inflammatory cytokines,
Taro, Kawai, Shizuo, Akira
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Pattern recognition receptor function in neutrophils

Trends in Immunology, 2013
Previously, neutrophils were largely ignored in the pattern recognition receptor (PRR) signaling field. However, interest in neutrophil biology has been revitalized by emerging roles for neutrophils in promoting protective and pathogenic T helper (Th)17-driven immune responses and in orchestrating innate and adaptive immunity via cytokine/chemokine ...
Thomas, Christina J., Schroder, Kate
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Pattern-recognition Receptors in Pulp Defense

Advances in Dental Research, 2011
Initial sensing of infection is mediated by germline-encoded pattern-recognition receptors (PRRs), the activation of which leads to the expression of inflammatory mediators responsible for the elimination of pathogens and infected cells. PRRs act as immune sensors that provide immediate cell responses to pathogen invasion or tissue injury.
M-J, Staquet, F, Carrouel, J-F, Keller, C, Baudouin, P, Msika, F, Bleicher, T A, Kufer, J-C, Farges   +7 more
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Pattern Recognition by Toll-like Receptors

2009
The mammalian immune system senses pathogens through pattern recognition receptors and responds with activation. The Toll-like receptors (TLRs) that are expressed on antigen presenting cells such as macrophages and dendritic cells play a critical role in this process.
Stefan, Bauer, Thomas, Müller, Svetlana, Hamm   +2 more
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CD14 Is a pattern recognition receptor

Immunity, 1994
Septic shock caused by a diverse group of bacterial pathogens is a serious human disease. Recognition of bacterial envelope constituents is one mechanism used by mammalian cells to initiate responses leading to bacterial killing or, unfortunately, responses that also cause fatal septic shock.
J, Pugin, I D, Heumann, A, Tomasz, V V, Kravchenko, Y, Akamatsu, M, Nishijima, M P, Glauser, P S, Tobias, R J, Ulevitch   +8 more
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WSA03 ‐ Pattern Recognition Receptors

European Journal of Immunology, 2009
AbstractNo ...
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Pattern Recognition Receptor Antagonism

Science Signaling, 2014
A pathogenic fungus activates two C-type lectin receptors to skew the T cell response to one favorable to infection.
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