Results 61 to 70 of about 8,051 (168)

Biphenotypic Sinonasal Sarcoma With a Novel PAX3::MAML2 Fusion

Genes, Chromosomes and Cancer, Volume 65, Issue 7, July 2026.
ABSTRACT Biphenotypic sinonasal sarcoma (BSNS) is a rare, low‐grade spindle cell sarcoma of the sinonasal tract. It is characterized by dual neural and myogenic differentiation and classically shows fusions involving PAX3. MAML3, a co‐activator in the Notch signaling pathway, is the most common fusion partner of PAX3.
Mayu Uemura, Anna Fong Na Goh, Amit Kumar, Gary Quagliotto, Pranav Dorwal   +4 more
wiley   +1 more source

A gene regulatory network underlying the formation of pre-placodal ectoderm in Xenopus laevis

BMC Biology, 2018
Background The neural plate border ectoderm gives rise to key developmental structures during embryogenesis, including the neural crest and the preplacodal ectoderm.
Santosh Kumar Maharana, Gerhard Schlosser   +1 more
doaj   +1 more source

Light‐Inducible Activation of FGFR3 Facilitates Chondrocyte Maturation

Cell Proliferation, Volume 59, Issue 7, July 2026.
Light‐inducible activation of FGFR3 induced robust activation of MAPK signaling, promoting proliferation and collagen depositon in induced chondrocytes and prevent the degeneration of osteoarthritic chondrocytes.
Mengze Sun, Yun Zhao, Yuqing Du, Yifei Fan, Kai Wang, Xiaoqing Hu   +5 more
wiley   +1 more source

Neuroblast-specific open chromatin allows the temporal transcription factor, Hunchback, to bind neuroblast-specific loci

eLife, 2019
Spatial and temporal cues are required to specify neuronal diversity, but how these cues are integrated in neural progenitors remains unknown. Drosophila progenitors (neuroblasts) are a good model: they are individually identifiable with relevant spatial
Sonia Q Sen, Sachin Chanchani, Tony D Southall, Chris Q Doe   +3 more
doaj   +1 more source

Protein kinase D2 is an essential regulator of murine myoblast differentiation. [PDF]

PLoS ONE, 2011
Muscle differentiation is a highly conserved process that occurs through the activation of quiescent satellite cells whose progeny proliferate, differentiate, and fuse to generate new myofibers.
Alexander Kleger, Christiane Loebnitz, Ganesh V Pusapati, Milena Armacki, Martin Müller, Stefan Tümpel, Anett Illing, Daniel Hartmann, Cornelia Brunner, Stefan Liebau, Karl L Rudolph, Guido Adler, Thomas Seufferlein   +12 more
doaj   +1 more source

Combinatorial expression of glial transcription factors induces Schwann cell‐specific gene expression in mouse embryonic fibroblasts

Developmental Dynamics, Volume 255, Issue 6, Page 548-566, June 2026.
Abstract Background Schwann cells provide peripheral nerve trophic support, myelinate axons, and assist in repair. However, Schwann cell repair capacity is limited by chronic injury, disease, and aging. Schwann cell reprogramming is a cellular conversion strategy that could provide a renewable cell supply to repair injured nerves.
Lauren Belfiore, Anjali Balakrishnan, Yacine Touahri, Dawn Zinyk, Humna Noman, Satoshi Okawa, Jeff Biernaskie, Carol Schuurmans   +7 more
wiley   +1 more source

Dual inhibition of KDM4B and KDM5A disassembles the PAX3-FOXO1 transcriptional program in fusion-positive rhabdomyosarcoma

Biology Direct
Background Fusion-positive rhabdomyosarcoma (FP-RMS) is driven by the oncogenic transcription factor PAX3-FOXO1 and is associated with poor clinical outcome.
Junhong Yuan, Qilei Han, Pengxuan Ren, Fang Bai, Xianglei Zhang, Kai Li   +5 more
doaj   +1 more source

Pax7 lineage contributions to the mammalian neural crest.

PLoS ONE, 2012
BackgroundNeural crest cells are vertebrate-specific multipotent cells that contribute to a variety of tissues including the peripheral nervous system, melanocytes, and craniofacial bones and cartilage.
Barbara Murdoch, Casey DelConte, Martín I García-Castro   +2 more
doaj   +1 more source

Integrative Advances in Equine Genomics From Reference Assemblies to Evolutionary History and Key Traits

Evolutionary Applications, Volume 19, Issue 6, June 2026.
ABSTRACT Horses are major domestic animals and cultural symbols that have accompanied humans for millennia. They underpin transport, agriculture, warfare and sport, and also provide a model for studying domestication, complex traits and adaptive evolution.
Ying Lu, Ruoshan Ma, Bo Wang, Jiao Wu, Yuqing Chong, Zhendong Gao, Weidong Deng   +6 more
wiley   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, Volume 600, Issue 9, Page 1265-1287, May 2026.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source