Results 141 to 150 of about 14,363 (238)

Evaluation of Drug–Drug Interaction Potential Between the Oral Antibiotic Zoliflodacin and the CYP3A4 Inhibitor Itraconazole: A Phase 1 Study in Healthy Participants

Clinical and Translational Science, Volume 19, Issue 3, March 2026.
ABSTRACT Zoliflodacin is a first‐in‐class oral spiropyrimidinetrione antibiotic being developed for patients with uncomplicated gonorrhea, including those infected with multidrug‐resistant strains. Because zoliflodacin is metabolized by cytochrome P450 3A4 (CYP3A4), concomitant administration with a CYP3A inhibitor has the potential to increase ...
Alison Luckey, Kajal B. Larson, Noha Rayad, Markus Heep, Sophie Delhomme, Gabrielle Kornmann, John P. Mueller, John P. O'Donnell, Seamus O'Brien, Rainard Fuhr, Jean‐Yves Gillon   +10 more
wiley   +1 more source

Comparison of dermal and inhalation routes of entry for organic chemicals [PDF]

The quantitative comparison of the chemical concentration inside the body as the result of a dermal exposure versus an inhalation exposure is useful for assessing human health risks and deciding on an appropriate protective posture.
Clewell, Harvey J., III, Jepson, Gary W., Mcdougal, James N.   +2 more
core   +1 more source

Modeling and Simulation of Triclosan Kinetics and Distribution in Humans Using a PBPK Model [PDF]

, 2015
Andreassen, Monica, Dirven, Hubert, Husøy, Trine, Lie, Bernt, Maharjan, Samee, Sharma, Roshan   +5 more
core   +4 more sources

Human PBPK Modeling

This deliverable will report the final development of the human PBPK models developed within ...
openaire   +1 more source

[[alternative]]Statistical Analysis on Environmental Risk Assessment Using Pharmacokinetic Physiologically-based Model [PDF]

計畫編號：NSC91-2118-M032-001研究期間：200208~200307研究經費：434,000[[sponsorship ...
陳主智
core  

Albumin Levels Are Predictive of Cachexia-Induced Time-Dependent Clearance of Therapeutic Antibodies: A Physiologically Based Pharmacokinetic Model of Durvalumab. [PDF]

CPT Pharmacometrics Syst Pharmacol
Proctor JR, Wong H.
europepmc   +1 more source

[[alternative]]Parameters Estimation of Physiologically-Based Pharmacokinetic Model Considering Dynamic Models [PDF]

計畫編號：NSC92-2118-M032-002研究期間：200308~200407研究經費：434,000[[sponsorship ...
陳主智
core  

From Population-Based PBPK to Individualized Virtual Twins: Clinical Validation and Applications in Medicine. [PDF]

J Clin Med
Gonçalves M, Barata P, Vale N.
europepmc   +1 more source

A PBPK model of Low-concentration Vitamin D Supplementation in the Absence of Sunlight [PDF]

, 2019
Sawyer, Colton
core   +1 more source

PBPK modeling of the antidepressant doxepin incorporating CYP2D6 genotype for precision pharmacotherapy. [PDF]

Arch Pharm Res
Seok J, Kang N, Lee JJ, Cho CK, Lee YJ.
europepmc   +1 more source