Results 141 to 150 of about 16,022 (277)
A Workflow Example of PBPK Modeling to Support Pediatric Research and Development: Case Study with Lorazepam [PDF]
, 2013 A. R. Maharaj +2 more
openalex +1 more source
Rules of Thumb for Estimating Drug Levels in Breast Milk: How Well Do They Work?
Clinical Pharmacology &Therapeutics, Volume 119, Issue 1, Page 101-108, January 2026.The American Academy of Pediatrics and the World Health Organization recommend exclusive breastfeeding for the first 6 months of life due to extensive benefits for the maternal–infant dyad. While over 90% of mothers initiate breastfeeding, continuation drops to 35% by 6 months, often due to concerns about medication safety.
Juliya Gasparyan +3 more
wiley +1 more source
Clinical Pharmacology &Therapeutics, Volume 119, Issue 1, Page 208-218, January 2026.Cystic fibrosis (CF) is a chronic hereditary disease that affects tens of thousands of people worldwide. The introduction of CFTR modulator therapies such as elexacaftor/tezacaftor/ivacaftor (ETI) has significantly improved the quality of life of people with CF.
Alan Shi +3 more
wiley +1 more source
AntibioticsThe appropriate use of antibiotics is crucial and involves selecting an optimal dosing regimen based on pharmacokinetic (PK) and pharmacodynamic (PD) indicators.
Ryota Tanaka, Kei Irie, Tomoyuki Mizuno
doaj +1 more source
Clinical Pharmacology &Therapeutics, Volume 119, Issue 1, Page 33-45, January 2026.T‐cell engaging antibodies (TCEs) and chimeric antigen receptor (CAR) T cells (CAR‐T cells) are among precision medicine therapies that have revolutionized the treatment of hematologic cancers. Their success in oncology has piqued interest in translating this promise into additional indications, such as autoimmune disorders.
Peter Ashcroft +6 more
wiley +1 more source
Quality Control Dissolution Data Is Biopredictive for a Modified Release Ropinirole Formulation: Virtual Experiment with the Use of Re-Developed and Verified PBPK Model [PDF]
, 2022 Olha Shuklinova +3 more
openalex +1 more source
Clinical Pharmacology &Therapeutics, Volume 119, Issue 1, Page 241-254, January 2026.Overview of the implemented pharmacogenomics (PGx) process in clinical routine at the Robert Bosch Hospital: from patient enrollment via the hospital information system, DNA detection using a customized TaqMan OpenArray panel and qPCR for CNV assessment, to clinical translation of genotyping results into PGx guideline‐based recommendations using a ...
Roman Tremmel +13 more
wiley +1 more source
Non-equilibrium entangled steady state of two independent two-level systems
, 2011 We determine and study the steady state of two independent two-level systems weakly coupled to a stationary non-equilibrium environment. Whereas this bipartite state is necessarily uncorrelated if the splitting energies of the two-level systems are ...
A. Peres +24 more
core +2 more sources