Results 191 to 200 of about 16,022 (277)

Addressing Adherence Using Genotype-Specific PBPK Modeling—Impact of Drug Holidays on Tamoxifen and Endoxifen Plasma Levels [PDF]

, 2017
Georg Hempel, Kristin J. R. Dickschen, Michael Block, Stefan Willmann   +3 more
core   +1 more source

Advancing inclusive healthcare through PBPK modelling: predicting the impact of CYP genotypes and enzyme ontogenies on infant exposures of venlafaxine and its active metabolite O-desmethylvenlafaxine in lactation [PDF]

Xian Pan, Karen Rowland Yeo
openalex   +1 more source

Digital Twins for Radiopharmaceutical Dosimetry: PBPK Modelling of [¹⁷⁷Lu]Lu-rhPSMA-10.1 in a Preclinical mCRPC Model. [PDF]

Cancers (Basel)
Costa G, Yousefzadeh-Nowshahr E, Vasic V, Sun B, Nagel L, Wurzer A, Schilling F, Beer A, Weber W, Kossatz S, Glatting G.   +10 more
europepmc   +1 more source

Enhanced CYP2C19-mediated drug-drug interaction risk with escitalopram in geriatric populations. [PDF]

Front Pharmacol
Byoun S, Heo DG, Lee M, Lee R, Li Y, Lee JY, Hong E, Lee W.   +7 more
europepmc   +1 more source

The Evolution and Future Directions of PBPK Modeling in FDA Regulatory Review. [PDF]

Pharmaceutics
Li Y, Sun H, Zhang Z.
europepmc   +1 more source

Modellierung PBPK-relevanter Verteilungskoeffizienten organischer Stoffe

, 2014
Drei Verteilungskoeffizienten, die für physiologie-basierte Pharmakokinetik (PBPK)-Modelle relevant sind, wurden mit verschiedenen Ansätzen modelliert. Für den Blut/Luft-Verteilungskoeffizienten wurde ein auf linearen Solvatations-Energie-Beziehungen (LSER) beruhendes Literaturmodell angewendet und diskutiert.
openaire   +1 more source

PopPK and PBPK Models Guide Meropenem Dosing in Critically Ill Children with Augmented Renal Clearance. [PDF]

Pharmaceutics
Liu Y, He H, Zhang SS, Zhou J, Zhu JW, Xu J, Miao HJ, Chen JH, Hao K.   +8 more
europepmc   +1 more source

Pharmacokinetics of CYP2C19- and CYP3A4-Metabolized Drugs in Cirrhosis Using a Whole-Body PBPK Approach. [PDF]

Pharmaceutics
Mu R, Gao J, Wang X, Ling J, Hu N, Yang H.   +5 more
europepmc   +1 more source

Analyzing parametric influences driving age-associated changes in absorption using a PBPK-GSA approach

Donnia Robins, Andreas Lehmann, Katharina Krollik, Maria Vertzoni   +3 more
openalex   +1 more source

Mechanistic Modelling of Lidocaine and Prilocaine Absorption from EMLA Cream upon Topical Application using Physiologically Based Pharmacokinetic Modelling. [PDF]

AAPS PharmSciTech
Telaprolu KC, Tsakalozou E, Ghosh P, Alam K, Grice JE, Roberts MS, Jamei M, Polak S, Clarke JF.   +8 more
europepmc   +1 more source